AR105332A1 - DERIVATIVES OF FENILETILAMINO-4H-PIRIMIDO [4,5-D] [1,3] OXAZIN-2-ONA AS INHIBITORS OF MUTANT IDH1 - Google Patents
DERIVATIVES OF FENILETILAMINO-4H-PIRIMIDO [4,5-D] [1,3] OXAZIN-2-ONA AS INHIBITORS OF MUTANT IDH1Info
- Publication number
- AR105332A1 AR105332A1 ARP160102106A ARP160102106A AR105332A1 AR 105332 A1 AR105332 A1 AR 105332A1 AR P160102106 A ARP160102106 A AR P160102106A AR P160102106 A ARP160102106 A AR P160102106A AR 105332 A1 AR105332 A1 AR 105332A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxazin
- azetidine
- inhibitors
- feniletilamino
- pirimido
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporcionan compuestos de feniletilamino-4H-pirimido[4,5-d][1,3]oxazin-2-ona, formulaciones que contienen esos compuestos, y su uso como inhibidores mutantes isocitrato deshidrogenasa 1 de enzimas. Reivindicación 1: Un compuesto de la fórmula (1) en el que L es un enlazador seleccionado del grupo que consiste en -N-azetidina-3-CH₂-O-, -N-azetidina-3-O-(CH₂)-, -N-2,6-diazaespiro[3.3]heptano-6-(CH₂)-, -N-piperazina-4-(CH₂)-, -N-piperazina, -N-azetidina-3-(CH₂CH₂)-, -7-N-(2,7-diazaespiro[3.5]nonano)-2-(CH₂), -N-azetidina-3-(NMe)CH₂-, -N-piperidin-4-(NMe)CH₂-, N-2,5-dihidropirrol-3-(CH₂)-O-; Z se selecciona de grupo que consiste en H o F; R se selecciona de grupo que consiste en alquilo C₁₋₄, -CH(CH₃)CH₂-OH, -CH₂CH₂F, -CH₂CHF₂; o una sal aceptable para uso farmacéutico del mismo.Phenylethylamino-4H-pyrimido [4,5-d] [1,3] oxazin-2-one compounds, formulations containing those compounds, and their use as mutant inhibitors isocytrate dehydrogenase 1 enzymes are provided. Claim 1: A compound of the formula (1) wherein L is a linker selected from the group consisting of -N-azetidine-3-CH₂-O-, -N-azetidine-3-O- (CH₂) -, -N-2,6-diazaspiro [3.3] heptane-6- (CH₂) -, -N-piperazine-4- (CH₂) -, -N-piperazine, -N-azetidine-3- (CH₂CH₂) -, - 7-N- (2,7-diazaspiro [3.5] nonane) -2- (CH₂), -N-azetidine-3- (NMe) CH₂-, -N-piperidin-4- (NMe) CH₂-, N- 2,5-dihydropyrrol-3- (CH₂) -O-; Z is selected from the group consisting of H or F; R is selected from the group consisting of C₁₋₄ alkyl, -CH (CH₃) CH₂-OH, -CH₂CH₂F, -CH₂CHF₂; or a salt acceptable for pharmaceutical use thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15382386 | 2015-07-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR105332A1 true AR105332A1 (en) | 2017-09-27 |
Family
ID=53785593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160102106A AR105332A1 (en) | 2015-07-27 | 2016-07-12 | DERIVATIVES OF FENILETILAMINO-4H-PIRIMIDO [4,5-D] [1,3] OXAZIN-2-ONA AS INHIBITORS OF MUTANT IDH1 |
Country Status (1)
Country | Link |
---|---|
AR (1) | AR105332A1 (en) |
-
2016
- 2016-07-12 AR ARP160102106A patent/AR105332A1/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DOP2018000187A (en) | DERIVATIVES OF PIRAZOLO [1,5-A] PIRAZIN-4-ILO | |
PE20171307A1 (en) | TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF | |
PE20190656A1 (en) | TIAZOLO-PYRIDINE COMPOUNDS REPLACED AS INHIBITORS OF MALT1 | |
DOP2017000038A (en) | 2- (MORFOLIN-4-IL) -1,7-NAFTIRIDINS | |
PE20181093A1 (en) | HETEROCYCLIC COMPOUNDS AND USES OF THEM | |
BR112016016844A2 (en) | HETEROCYCLIC COMPOUNDS | |
PE20190811A1 (en) | DERIVATIVES OF PYRAZOLOPYRIMIDINES AS A KINASE INHIBITOR | |
PE20181298A1 (en) | BIVALENT BROMODOMINIUM INHIBITORS AND USES OF THEM | |
DOP2018000268A (en) | USEFUL REPLACED CARBONUCLEOSIDE DERIVATIVES AS ANTHINEOPLASTIC AGENTS | |
CR20170384A (en) | DERIVATIVES OF USEFUL REPLACED NUCLEOSIDS AS ANTINEOPLASIC AGENTS | |
PE20160588A1 (en) | TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINE COMPOUNDS, C-MET INHIBITORS AND COMPOSITIONS THEREOF | |
AR093244A1 (en) | SUBSTITUTED BENZENE COMPOUNDS USED IN THE TREATMENT OF EZH2-DISORDERS | |
EA201692249A1 (en) | PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS | |
EA201790108A1 (en) | HETEROARRYL COMPOUNDS SUITABLE AS AN INHIBITOR SUMO-ACTIVATING ENZYME | |
CO6620055A2 (en) | Certain amino-pyrimidines, compositions thereof and methods for the use thereof | |
AR078157A1 (en) | DERIVATIVES OF PIRAZOL- [4,5-D] PIRROLO [2,3-B] PYRIDINE INHIBITORS OF JAK 2 THYROSINQUINASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND USE OF THE SAME IN THE TREATMENT OF CANCER | |
ECSP17007208A (en) | DERIVATIVES OF INDANO AND INDOLINE AND THE USE OF THE SAME AS ACTIVATORS OF SOLUBLE GUANILATE CYCLASE | |
EA201692266A1 (en) | PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS | |
EA201692265A1 (en) | PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS | |
EA201490471A1 (en) | PYRIDAZINOUS COMPOUNDS AND THEIR APPLICATION AS DAAO INHIBITORS | |
EA201591804A1 (en) | DERIVATIVES 2 - ((4-AMINO-3- (3-Fluoro-5-hydroxyphenyl) -1H-Pyrazolo [3,4-D] Pyrimidin-1-IL) METHYL) -3- (2- (Trifluoromethyl) Benzyl) KHINAZOLIN-4 (3H) -ONE and THEIR APPLICATION AS PHOSFOINOSYTID-3-KINASE inhibitors | |
PE20142366A1 (en) | TRIAZOLO COMPOUNDS AS PDE INHIBITORS 10 | |
CR20190310A (en) | Pyrazolopyrimidine compounds and methods of use thereof | |
MA39707A (en) | 1,2-DIHYDRO-3H-PYRROLO [1,2-C] IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | |
AR076053A1 (en) | DERIVATIVES OF PIRAZOLO [1,5-A] PYRIMIDINE AS MOTOR INHIBITORS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |