AR105332A1 - DERIVATIVES OF FENILETILAMINO-4H-PIRIMIDO [4,5-D] [1,3] OXAZIN-2-ONA AS INHIBITORS OF MUTANT IDH1 - Google Patents

DERIVATIVES OF FENILETILAMINO-4H-PIRIMIDO [4,5-D] [1,3] OXAZIN-2-ONA AS INHIBITORS OF MUTANT IDH1

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Publication number
AR105332A1
AR105332A1 ARP160102106A ARP160102106A AR105332A1 AR 105332 A1 AR105332 A1 AR 105332A1 AR P160102106 A ARP160102106 A AR P160102106A AR P160102106 A ARP160102106 A AR P160102106A AR 105332 A1 AR105332 A1 AR 105332A1
Authority
AR
Argentina
Prior art keywords
oxazin
azetidine
inhibitors
feniletilamino
pirimido
Prior art date
Application number
ARP160102106A
Other languages
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR105332A1 publication Critical patent/AR105332A1/en

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Abstract

Se proporcionan compuestos de feniletilamino-4H-pirimido[4,5-d][1,3]oxazin-2-ona, formulaciones que contienen esos compuestos, y su uso como inhibidores mutantes isocitrato deshidrogenasa 1 de enzimas. Reivindicación 1: Un compuesto de la fórmula (1) en el que L es un enlazador seleccionado del grupo que consiste en -N-azetidina-3-CH₂-O-, -N-azetidina-3-O-(CH₂)-, -N-2,6-diazaespiro[3.3]heptano-6-(CH₂)-, -N-piperazina-4-(CH₂)-, -N-piperazina, -N-azetidina-3-(CH₂CH₂)-, -7-N-(2,7-diazaespiro[3.5]nonano)-2-(CH₂), -N-azetidina-3-(NMe)CH₂-, -N-piperidin-4-(NMe)CH₂-, N-2,5-dihidropirrol-3-(CH₂)-O-; Z se selecciona de grupo que consiste en H o F; R se selecciona de grupo que consiste en alquilo C₁₋₄, -CH(CH₃)CH₂-OH, -CH₂CH₂F, -CH₂CHF₂; o una sal aceptable para uso farmacéutico del mismo.Phenylethylamino-4H-pyrimido [4,5-d] [1,3] oxazin-2-one compounds, formulations containing those compounds, and their use as mutant inhibitors isocytrate dehydrogenase 1 enzymes are provided. Claim 1: A compound of the formula (1) wherein L is a linker selected from the group consisting of -N-azetidine-3-CH₂-O-, -N-azetidine-3-O- (CH₂) -, -N-2,6-diazaspiro [3.3] heptane-6- (CH₂) -, -N-piperazine-4- (CH₂) -, -N-piperazine, -N-azetidine-3- (CH₂CH₂) -, - 7-N- (2,7-diazaspiro [3.5] nonane) -2- (CH₂), -N-azetidine-3- (NMe) CH₂-, -N-piperidin-4- (NMe) CH₂-, N- 2,5-dihydropyrrol-3- (CH₂) -O-; Z is selected from the group consisting of H or F; R is selected from the group consisting of C₁₋₄ alkyl, -CH (CH₃) CH₂-OH, -CH₂CH₂F, -CH₂CHF₂; or a salt acceptable for pharmaceutical use thereof.

ARP160102106A 2015-07-27 2016-07-12 DERIVATIVES OF FENILETILAMINO-4H-PIRIMIDO [4,5-D] [1,3] OXAZIN-2-ONA AS INHIBITORS OF MUTANT IDH1 AR105332A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15382386 2015-07-27

Publications (1)

Publication Number Publication Date
AR105332A1 true AR105332A1 (en) 2017-09-27

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ID=53785593

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102106A AR105332A1 (en) 2015-07-27 2016-07-12 DERIVATIVES OF FENILETILAMINO-4H-PIRIMIDO [4,5-D] [1,3] OXAZIN-2-ONA AS INHIBITORS OF MUTANT IDH1

Country Status (1)

Country Link
AR (1) AR105332A1 (en)

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