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Sistemas, métodos y composiciones para el direccionamiento de ácidos nucleicos. En particular, provee sistemas de direccionamiento de ADN no natural o manipulado que comprende una proteína efectora CRISPR de, direccionamiento de ADN o ARN y por lo menos un componente de ácido nucleico de direccionamiento tal como un ARN guía. También se divulgan y reivindican métodos para elaborar y utilizar, y los usos, de dichos sistemas, métodos y composiciones, y productos de dichos métodos y usos.Systems, methods and compositions for nucleic acid targeting. In particular, it provides non-natural or manipulated DNA targeting systems comprising a CRISPR effector protein, DNA or RNA targeting and at least one targeting nucleic acid component such as a guide RNA. Methods for making and using, and the uses, of said systems, methods and compositions, and products of said methods and uses are also disclosed and claimed.
ARP160101833A2015-06-182016-06-21
ENZYMES AND CRISPR SYSTEMS
AR105066A1
(en)
oncolytic virus, virus expressing three heterologous genes, pharmaceutical composition, virus for use, manufacturing product, cancer treatment method, and virus use