AR104805A1 - METHODS AND COMPOSITIONS TO EVALUATE CANCER RESPONSE RESPONSE TO BET INHIBITORS - Google Patents

METHODS AND COMPOSITIONS TO EVALUATE CANCER RESPONSE RESPONSE TO BET INHIBITORS

Info

Publication number
AR104805A1
AR104805A1 ARP160101552A ARP160101552A AR104805A1 AR 104805 A1 AR104805 A1 AR 104805A1 AR P160101552 A ARP160101552 A AR P160101552A AR P160101552 A ARP160101552 A AR P160101552A AR 104805 A1 AR104805 A1 AR 104805A1
Authority
AR
Argentina
Prior art keywords
methods
cancer
response
subject
bet
Prior art date
Application number
ARP160101552A
Other languages
Spanish (es)
Inventor
Mesh Kathryn
L Mcleland Mark
Firestein Ron
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR104805A1 publication Critical patent/AR104805A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen métodos de tratamiento de un sujeto que tiene cáncer con un inhibidor de BET, métodos de selección de un sujeto para el tratamiento con un inhibidor de BET, métodos de predicción de la capacidad de respuesta de un sujeto que tiene cáncer a un inhibidor de BET, métodos de comunicación de la probabilidad de respuesta de un sujeto que tiene cáncer a un inhibidor de BET y métodos de modulación del tratamiento de un sujeto que se somete a un tratamiento con inhibidores de BET para cáncer. Los métodos descritos incluyen las etapas para llevar a cabo un ensayo de detección a base de ácido nucleico para detectar el nivel de expresión de un eARN transcrito de un elemento potenciador asociado con mic en una muestra que contiene células cancerosas del sujeto y determinar el nivel de expresión del eARN en las células en la muestra.Methods of treating a subject who has cancer with a BET inhibitor, methods of selecting a subject for treatment with a BET inhibitor, methods of predicting the responsiveness of a subject having cancer to an inhibitor of cancer are described. BET, methods of communicating the likelihood of response of a subject who has cancer to a BET inhibitor and methods of modulating the treatment of a subject undergoing treatment with BET inhibitors for cancer. The methods described include the steps to carry out a nucleic acid based detection assay to detect the level of expression of a transcribed eRNA of an enhancer element associated with mic in a sample containing the subject's cancer cells and determine the level of eRNA expression in the cells in the sample.

ARP160101552A 2015-05-29 2016-05-27 METHODS AND COMPOSITIONS TO EVALUATE CANCER RESPONSE RESPONSE TO BET INHIBITORS AR104805A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562168691P 2015-05-29 2015-05-29

Publications (1)

Publication Number Publication Date
AR104805A1 true AR104805A1 (en) 2017-08-16

Family

ID=56117996

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160101552A AR104805A1 (en) 2015-05-29 2016-05-27 METHODS AND COMPOSITIONS TO EVALUATE CANCER RESPONSE RESPONSE TO BET INHIBITORS

Country Status (2)

Country Link
AR (1) AR104805A1 (en)
WO (1) WO2016196065A1 (en)

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US11708600B2 (en) * 2017-10-05 2023-07-25 Decode Health, Inc. Long non-coding RNA gene expression signatures in disease diagnosis
WO2019113260A1 (en) * 2017-12-05 2019-06-13 The Regents Of The University Of Colorado A Body Corporate Genomic targets of histone deacetylase inhibitors (hdaci) and methods of use thereof
WO2020227213A1 (en) * 2019-05-03 2020-11-12 Icahn School Of Medicine At Mount Sinai Methods of controlling and improving brain health
CN115190800A (en) * 2020-03-09 2022-10-14 石药集团中奇制药技术（石家庄）有限公司 Application of BRD4 inhibitor

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Also Published As

Publication number Publication date
WO2016196065A1 (en) 2016-12-08

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