AR104514A1 - PROTEIN-POLISACÁRIDO CONJUGATES OF ESTREPTOCOCO GROUP B, METHODS TO PRODUCE CONJUGATES, IMMUNOGEN COMPOSITIONS THAT INCLUDE CONJUGATES AND THEIR USES - Google Patents
PROTEIN-POLISACÁRIDO CONJUGATES OF ESTREPTOCOCO GROUP B, METHODS TO PRODUCE CONJUGATES, IMMUNOGEN COMPOSITIONS THAT INCLUDE CONJUGATES AND THEIR USESInfo
- Publication number
- AR104514A1 AR104514A1 ARP160101259A ARP160101259A AR104514A1 AR 104514 A1 AR104514 A1 AR 104514A1 AR P160101259 A ARP160101259 A AR P160101259A AR P160101259 A ARP160101259 A AR P160101259A AR 104514 A1 AR104514 A1 AR 104514A1
- Authority
- AR
- Argentina
- Prior art keywords
- conjugates
- protein
- gbs
- methods
- group
- Prior art date
Links
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Conjugados inmunógenos proteína-polisacárido que comprenden un polisacárido capsular (CP) de Streptococcus agalactiae, denominado comúnmente estreptococo grupo B (GBS), y una proteína portadora, en donde CP se selecciona del grupo que consiste en los serotipos Ia, Ib, II, III, IV, V, VI, VII, VIII y IX, y en donde CP tiene un nivel de ácido siálico mayor de alrededor de 60%. También métodos para obtener los conjugados y las composiciones inmunógenas que comprenden los conjugados. Además composiciones inmunógenas que comprenden conjugados proteína-polisacárido, en donde los conjugados comprenden un CP de GBS serotipo IV y al menos un serotipo adicional. Asimismo, métodos para inducir una respuesta inmunitaria en sujetos contra GBS y/o para reducir o prevenir la enfermedad por GBS invasivo en sujetos usando las composiciones descritas en la presente. Los anticuerpos resultantes se pueden usar para tratar o prevenirla infección por GBS mediante inmunoterapia pasiva.Protein-polysaccharide immunogenic conjugates comprising a capsular polysaccharide (CP) of Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein CP is selected from the group consisting of serotypes Ia, Ib, II, III , IV, V, VI, VII, VIII and IX, and where CP has a sialic acid level greater than about 60%. Also methods for obtaining the conjugates and the immunogenic compositions comprising the conjugates. In addition, immunogenic compositions comprising protein-polysaccharide conjugates, wherein the conjugates comprise a GBS CP serotype IV and at least one additional serotype. Likewise, methods to induce an immune response in subjects against GBS and / or to reduce or prevent invasive GBS disease in subjects using the compositions described herein. The resulting antibodies can be used to treat or prevent GBS infection by passive immunotherapy.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562156500P | 2015-05-04 | 2015-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104514A1 true AR104514A1 (en) | 2017-07-26 |
Family
ID=59485531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101259A AR104514A1 (en) | 2015-05-04 | 2016-05-03 | PROTEIN-POLISACÁRIDO CONJUGATES OF ESTREPTOCOCO GROUP B, METHODS TO PRODUCE CONJUGATES, IMMUNOGEN COMPOSITIONS THAT INCLUDE CONJUGATES AND THEIR USES |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR104514A1 (en) |
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2016
- 2016-05-03 AR ARP160101259A patent/AR104514A1/en unknown
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| AR104514A1 (en) | PROTEIN-POLISACÁRIDO CONJUGATES OF ESTREPTOCOCO GROUP B, METHODS TO PRODUCE CONJUGATES, IMMUNOGEN COMPOSITIONS THAT INCLUDE CONJUGATES AND THEIR USES |