AR104502A1 - PROCEDURE FOR THE PREPARATION OF 2- {4- [2 - ({[2- (4-CHLOROPHENYL) -1,3-TIAZOL-4-IL] METHYL} SULFANIL) -3,5-DICIAN-6- (PIRROLIDIN- 1-IL) PIRIDINA-4-IL] PHENOXI} ETIL-L-ALANIL-L-ALANINATO-MONOHIDROCLORURO - Google Patents

PROCEDURE FOR THE PREPARATION OF 2- {4- [2 - ({[2- (4-CHLOROPHENYL) -1,3-TIAZOL-4-IL] METHYL} SULFANIL) -3,5-DICIAN-6- (PIRROLIDIN- 1-IL) PIRIDINA-4-IL] PHENOXI} ETIL-L-ALANIL-L-ALANINATO-MONOHIDROCLORURO

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Publication number
AR104502A1
AR104502A1 ARP160101245A ARP160101245A AR104502A1 AR 104502 A1 AR104502 A1 AR 104502A1 AR P160101245 A ARP160101245 A AR P160101245A AR P160101245 A ARP160101245 A AR P160101245A AR 104502 A1 AR104502 A1 AR 104502A1
Authority
AR
Argentina
Prior art keywords
chlorophenyl
methyl
monohidrocloruro
dician
alaninato
Prior art date
Application number
ARP160101245A
Other languages
Spanish (es)
Inventor
Becker Guido
Keil Birgit
Dr Olenik Britta
Dr Heilmann Werner
Dr Mais Franz-Josef
Original Assignee
Bayer Pharma Aktiegesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiegesellschaft filed Critical Bayer Pharma Aktiegesellschaft
Publication of AR104502A1 publication Critical patent/AR104502A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Reivindicación 1: 2-{4-[2-({[2-(4-clorofenil)-1,3-tiazol-4-il]metil}sulfanil)-3,5-diciano-6-(pirrolidin-1-il)piridina-4-il]fenoxi}etil-L-alanil-L-alaninato-monohidrocloruro de la fórmula (1) en forma cristalina de la modificación I caracterizado porque el difractograma de rayos X del compuesto muestra un pico máximo del ángulo 2q en 6.5, 8.7 y 24.3.Claim 1: 2- {4- [2 - ({[2- (4-chlorophenyl) -1,3-thiazol-4-yl] methyl} sulfanyl) -3,5-dicyano-6- (pyrrolidin-1- il) pyridine-4-yl] phenoxy} ethyl-L-alanyl-L-alaninate-monohydrochloride of the formula (1) in crystalline form of modification I characterized in that the X-ray diffractogram of the compound shows a maximum peak of angle 2q in 6.5, 8.7 and 24.3.

ARP160101245A 2015-05-06 2016-05-02 PROCEDURE FOR THE PREPARATION OF 2- {4- [2 - ({[2- (4-CHLOROPHENYL) -1,3-TIAZOL-4-IL] METHYL} SULFANIL) -3,5-DICIAN-6- (PIRROLIDIN- 1-IL) PIRIDINA-4-IL] PHENOXI} ETIL-L-ALANIL-L-ALANINATO-MONOHIDROCLORURO AR104502A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15166606 2015-05-06

Publications (1)

Publication Number Publication Date
AR104502A1 true AR104502A1 (en) 2017-07-26

Family

ID=53283983

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160101245A AR104502A1 (en) 2015-05-06 2016-05-02 PROCEDURE FOR THE PREPARATION OF 2- {4- [2 - ({[2- (4-CHLOROPHENYL) -1,3-TIAZOL-4-IL] METHYL} SULFANIL) -3,5-DICIAN-6- (PIRROLIDIN- 1-IL) PIRIDINA-4-IL] PHENOXI} ETIL-L-ALANIL-L-ALANINATO-MONOHIDROCLORURO

Country Status (1)

Country Link
AR (1) AR104502A1 (en)

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