AR104216A1 - PRODUCTION OF LARGE SIZE ADENO-ASSOCIATE VECTORS - Google Patents

PRODUCTION OF LARGE SIZE ADENO-ASSOCIATE VECTORS

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Publication number
AR104216A1
AR104216A1 ARP160100958A ARP160100958A AR104216A1 AR 104216 A1 AR104216 A1 AR 104216A1 AR P160100958 A ARP160100958 A AR P160100958A AR P160100958 A ARP160100958 A AR P160100958A AR 104216 A1 AR104216 A1 AR 104216A1
Authority
AR
Argentina
Prior art keywords
aav
raav
adeno
genome
particles
Prior art date
Application number
ARP160100958A
Other languages
Spanish (es)
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of AR104216A1 publication Critical patent/AR104216A1/en

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se proporcionan aquí métodos para producir una partícula de virus adenoasociado (AAV) que contiene un genoma de AAV recombinante de gran tamaño (por ejemplo, más de 4,7 kb). En algunos aspectos, se proporciona partículas AAV y vectores de AAV que comprenden genomas de virus adenoasociados recombinantes (rAAV) de gran tamaño. También se proporcionan líneas celulares productoras para producir partículas AAV que comprenden genomas de gran tamaño. Reivindicación 1: Un método para producir una partícula de virus adenoasociado (AAV) que comprende un genoma de AAV recombinante de gran tamaño, comprendiendo el método a) cultivar una línea celular productora de AAV en condiciones para generar partículas rAAV, en el que la línea celular productora de AAV comprende i) ácido nucleico que codifica genes rep y cap de AAV, y ii) un genoma de rAAV, en el que el genoma de rAAV tiene más de aproximadamente 4,7 kb; b) proporcionar funciones auxiliares de AAV; y c) recoger las partículas rAAV que comprenden genomas de rAAV de gran tamaño.Methods for producing an adeno-associated virus (AAV) particle containing a large recombinant AAV genome (eg, more than 4.7 kb) are provided herein. In some aspects, AAV particles and AAV vectors are provided comprising large recombinant adeno-associated virus (rAAV) genomes. Producer cell lines are also provided to produce AAV particles comprising large genomes. Claim 1: A method for producing an adeno-associated virus (AAV) particle comprising a large recombinant AAV genome, the method comprising a) culturing an AAV-producing cell line under conditions to generate rAAV particles, in which the line AAV-producing cell comprises i) nucleic acid encoding AAV rep and cap genes, and ii) a rAAV genome, in which the rAAV genome has more than about 4.7 kb; b) provide auxiliary AAV functions; and c) collecting the rAAV particles comprising large rAAV genomes.

ARP160100958A 2015-04-08 2016-04-08 PRODUCTION OF LARGE SIZE ADENO-ASSOCIATE VECTORS AR104216A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562144862P 2015-04-08 2015-04-08

Publications (1)

Publication Number Publication Date
AR104216A1 true AR104216A1 (en) 2017-07-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160100958A AR104216A1 (en) 2015-04-08 2016-04-08 PRODUCTION OF LARGE SIZE ADENO-ASSOCIATE VECTORS

Country Status (2)

Country Link
AR (1) AR104216A1 (en)
MA (1) MA41387B1 (en)

Also Published As

Publication number Publication date
MA41387B1 (en) 2021-04-30
MA41387A1 (en) 2018-10-31

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