AR103529A1 - PROTEIN OF UNION TO ICOS OR PORTION OF UNION TO THE ANTIGEN OF THE SAME, MONOCLONAL ANTIBODY OF THE SAME AND PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS - Google Patents
PROTEIN OF UNION TO ICOS OR PORTION OF UNION TO THE ANTIGEN OF THE SAME, MONOCLONAL ANTIBODY OF THE SAME AND PHARMACEUTICAL COMPOSITION THAT UNDERSTANDSInfo
- Publication number
- AR103529A1 AR103529A1 ARP160100214A ARP160100214A AR103529A1 AR 103529 A1 AR103529 A1 AR 103529A1 AR P160100214 A ARP160100214 A AR P160100214A AR P160100214 A ARP160100214 A AR P160100214A AR 103529 A1 AR103529 A1 AR 103529A1
- Authority
- AR
- Argentina
- Prior art keywords
- icos
- union
- same
- seq
- lymphocyte
- Prior art date
Links
Abstract
Una proteína de unión a ICOS o porción de unión al antígeno de la misma que es un agonista para ICOS humana y no induce complemento, ADCC o CDC cuando se pone en contacto con un linfocito T in vivo y de aplicación en métodos de tratamiento de cáncer, enfermedades infecciosas y/o sepsis con dicha proteína de unión a ICOS o una porción de unión al antígeno de la misma. Adicionalmente, las proteínas de unión a ICOS o porciones de unión al antígeno de las mismas son capaces de activar un linfocito T cuando se pone en contacto con dicho linfocito T; estimular la proliferación de linfocitos T cuando se ponen en contacto con dicho linfocito T y/o inducir la producción de citocinas cuando se ponen en contacto con dicho linfocito T. Las proteínas de unión a ICOS o porciones de unión al antígeno de las mismas comprenden uno o más de: SEC ID Nº 1; SEC ID Nº 2; SEC ID Nº 3; SEC ID Nº 4; SEC ID Nº 5; y/o SEC ID Nº 6.An ICOS binding protein or antigen binding portion thereof that is an agonist for human ICOS and does not induce complement, ADCC or CDC when contacted with a T lymphocyte in vivo and for application in cancer treatment methods , infectious diseases and / or sepsis with said ICOS binding protein or an antigen binding portion thereof. Additionally, the ICOS binding proteins or antigen binding portions thereof are capable of activating a T lymphocyte when contacted with said T lymphocyte; stimulating T lymphocyte proliferation when contacted with said T lymphocyte and / or inducing cytokine production when contacted with said T lymphocyte. ICOS binding proteins or antigen binding portions thereof comprise one or more than: SEQ ID NO: 1; SEQ ID NO. 2; SEQ ID NO. 3; SEQ ID NO. 4; SEQ ID No. 5; and / or SEQ ID NO. 6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562108605P | 2015-01-28 | 2015-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR103529A1 true AR103529A1 (en) | 2017-05-17 |
Family
ID=58951273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160100214A AR103529A1 (en) | 2015-01-28 | 2016-01-26 | PROTEIN OF UNION TO ICOS OR PORTION OF UNION TO THE ANTIGEN OF THE SAME, MONOCLONAL ANTIBODY OF THE SAME AND PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR103529A1 (en) |
-
2016
- 2016-01-26 AR ARP160100214A patent/AR103529A1/en unknown
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