AR102887A1 - A TRIAZOLOPIRIDAZINE AS A KINASE MODULATOR - Google Patents

A TRIAZOLOPIRIDAZINE AS A KINASE MODULATOR

Info

Publication number
AR102887A1
AR102887A1 ARP150103951A ARP150103951A AR102887A1 AR 102887 A1 AR102887 A1 AR 102887A1 AR P150103951 A ARP150103951 A AR P150103951A AR P150103951 A ARP150103951 A AR P150103951A AR 102887 A1 AR102887 A1 AR 102887A1
Authority
AR
Argentina
Prior art keywords
compounds
met
individual
triazolopiridazine
cell
Prior art date
Application number
ARP150103951A
Other languages
Spanish (es)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR102887A1 publication Critical patent/AR102887A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se refiere a un compuesto triazolopiridazina de fórmula (1), N-óxidos, sales y solvatos farmacéuticamente aceptables de este, donde D representa deuterio, el uso de estos compuestos como moduladores de la proteína tirosina quinasa, particularmente inhibidores de c-Met, y el uso de esos compuestos para reducir o inhibir la actividad quinasa de c-Met en una célula o individuo y el uso de esos compuestos para prevenir o tratar un trastorno proliferativo celular y/o trastornos proliferativos relacionados con c-Met en un individuo. La presente se refiere además a composiciones farmacéuticas que comprenden los compuestos de la presente.It refers to a pharmaceutically acceptable triazolopyridazine compound of formula (1), N-oxides, salts and solvates thereof, where D represents deuterium, the use of these compounds as modulators of the protein tyrosine kinase, particularly c-Met inhibitors, and the use of those compounds to reduce or inhibit c-Met kinase activity in a cell or individual and the use of those compounds to prevent or treat a cell proliferative disorder and / or proliferative disorders related to c-Met in an individual. The present further refers to pharmaceutical compositions comprising the compounds herein.

ARP150103951A 2014-12-04 2015-12-03 A TRIAZOLOPIRIDAZINE AS A KINASE MODULATOR AR102887A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14196387 2014-12-04

Publications (1)

Publication Number Publication Date
AR102887A1 true AR102887A1 (en) 2017-03-29

Family

ID=52006894

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103951A AR102887A1 (en) 2014-12-04 2015-12-03 A TRIAZOLOPIRIDAZINE AS A KINASE MODULATOR

Country Status (1)

Country Link
AR (1) AR102887A1 (en)

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