AR102721A1 - PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALTS OF THE SAME - Google Patents

PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALTS OF THE SAME

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Publication number
AR102721A1
AR102721A1 ARP150103779A ARP150103779A AR102721A1 AR 102721 A1 AR102721 A1 AR 102721A1 AR P150103779 A ARP150103779 A AR P150103779A AR P150103779 A ARP150103779 A AR P150103779A AR 102721 A1 AR102721 A1 AR 102721A1
Authority
AR
Argentina
Prior art keywords
arformoterol
tartrate
formula
preparation
salts
Prior art date
Application number
ARP150103779A
Other languages
Spanish (es)
Inventor
Subhash Bhujbal Anil
Ashokrao Deshpande Aniket
Shrirang Pawase Shailesh
Baban Gavhane Sachin
Mahadev Kadam Suresh
Bhaskar Bhirud Shekhar
Original Assignee
Glenmark Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Ltd filed Critical Glenmark Pharmaceuticals Ltd
Priority to ARP150103779A priority Critical patent/AR102721A1/en
Publication of AR102721A1 publication Critical patent/AR102721A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente se relaciona con un proceso mejorado para la preparación de arformoterol L-(+)-tartrato. Mas específicamente se relaciona a un proceso para la preparación de arformoterol L-(+)-tartrato vía arformoterol D-(-)-tartrato. Reivindicación 1: Un proceso para la preparación de arformoterol L-(+)-tartrato de fórmula (1a), donde el nivel de compuestos de fórmula (3) ó (4), es menos del 0,15% p/p relativo a la cantidad de arformoterol L-(+)-tartrato según lo determinado mediante HPLC, que comprende: a) hacer reaccionar arformoterol bruto de fórmula (1) con ácido D-(-)-tartárico para formar arformoterol D-(-)-tartrato de fórmula (2); y b) hacer reaccionar arformoterol D-(-)-tartrato de fórmula (2) con una base y acido L-(+)-tartárico para formar arformoterol L-(+)- tartrato de fórmula (1a). Reivindicación 7: El proceso según lo reivindicado en la reivindicación 6, donde el isopropanol y el tolueno son utilizados en una proporción de 8:2 v/v.This is related to an improved process for the preparation of arformoterol L - (+) - tartrate. More specifically it relates to a process for the preparation of arformoterol L - (+) - tartrate via arformoterol D - (-) - tartrate. Claim 1: A process for the preparation of arformoterol L - (+) - tartrate of formula (1a), wherein the level of compounds of formula (3) or (4), is less than 0.15% w / w relative to the amount of arformoterol L - (+) - tartrate as determined by HPLC, which comprises: a) reacting crude arformoterol of formula (1) with D - (-) - tartaric acid to form arformoterol D - (-) - tartrate of formula (2); and b) reacting arformoterol D - (-) - tartrate of formula (2) with a base and L - (+) - tartaric acid to form arformoterol L - (+) - tartrate of formula (1a). Claim 7: The process as claimed in claim 6, wherein isopropanol and toluene are used in a ratio of 8: 2 v / v.

ARP150103779A 2015-11-20 2015-11-20 PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALTS OF THE SAME AR102721A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP150103779A AR102721A1 (en) 2015-11-20 2015-11-20 PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALTS OF THE SAME

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP150103779A AR102721A1 (en) 2015-11-20 2015-11-20 PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALTS OF THE SAME

Publications (1)

Publication Number Publication Date
AR102721A1 true AR102721A1 (en) 2017-03-22

Family

ID=58672849

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103779A AR102721A1 (en) 2015-11-20 2015-11-20 PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALTS OF THE SAME

Country Status (1)

Country Link
AR (1) AR102721A1 (en)

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