AR100763A1 - PEG-DENDRÓN HYBRID BASED AGROCHEMICAL RELEASE SYSTEM WHICH RESPONDS TO ENZYMES OR pH - Google Patents

PEG-DENDRÓN HYBRID BASED AGROCHEMICAL RELEASE SYSTEM WHICH RESPONDS TO ENZYMES OR pH

Info

Publication number
AR100763A1
AR100763A1 ARP150100557A ARP150100557A AR100763A1 AR 100763 A1 AR100763 A1 AR 100763A1 AR P150100557 A ARP150100557 A AR P150100557A AR P150100557 A ARP150100557 A AR P150100557A AR 100763 A1 AR100763 A1 AR 100763A1
Authority
AR
Argentina
Prior art keywords
hydrophobic
agrochemical
micelle
dendron
release system
Prior art date
Application number
ARP150100557A
Other languages
Spanish (es)
Inventor
Frid Liat
Rosenbaum Ido
Josef Harnoy Assaf
Buzhor Marina
Jacob Amir Roey
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Publication of AR100763A1 publication Critical patent/AR100763A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C08G83/004—After treatment of dendrimers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Reivindicación 1: Un sistema de liberación hibrido anfifílico en forma micelar para la liberación de agroquímicos, que comprende un polímero de polietilenglicol hidrofílico (PEG) conjugado con un dendrón hidrofóbico, donde el dendrón comprende al menos un grupo terminal hidrofóbico dependiente del pH o enzimáticamente escindible que se une covalentemente con el dendrón, en donde dicha micela comprende un agroquímico ya sea como parte del grupo terminal hidrofóbico o encapsulado dentro de la micela o ambos y en donde dicha micela se desensambla para liberar el agroquímico después de la escisión enzimática o dependiente del pH de dicho grupo terminal hidrofóbico. Reivindicación 16: El sistema de liberación híbrido de acuerdo con la reivindicación 15, en donde cada generación del dendrón se deriva de un compuesto seleccionado del grupo que consiste en HS-CH₂-CH₂-OH, HS-(CH₂)₁₋₃-CO₂H y HS-CH₂-CH(OH)-CH₂-OH. Reivindicación 46: Un método de liberación del agroquímico sistema hibrido anfifílico de acuerdo con cualquiera de las reivindicaciones precedentes, que comprende la etapa de puesta en contacto de una planta o los alrededores de la planta con el sistema de liberación híbrido anfifílico y una enzima o un agente de ajuste del pH en una cantidad efectiva para inducir la escisión del grupo terminal hidrofóbico escindible, desensamblando así dicha micela. Reivindicación 47: Un kit para liberar el agroquímico sistema híbrido anfifílico de acuerdo con cualquiera de las reivindicaciones precedentes, que comprende en un compartimiento el agroquímico sistema híbrido anfifílico y en un segundo compartimiento una enzima o un agente de ajuste del pH capaz de hidrolizar el grupo terminal hidrofóbico escindible de modo de desensamblar dicha micela.Claim 1: A micellar amphiphilic hybrid release system for the release of agrochemicals, comprising a hydrophilic polyethylene glycol (PEG) polymer conjugated to a hydrophobic dendron, wherein the dendron comprises at least one hydrophobic pH-dependent or enzymatically cleavable terminal group which covalently binds with the dendron, wherein said micelle comprises an agrochemical either as part of the hydrophobic or encapsulated terminal group within the micelle or both and wherein said micelle is disassembled to release the agrochemical after enzymatic or dependent cleavage of the pH of said hydrophobic terminal group. Claim 16: The hybrid release system according to claim 15, wherein each generation of the dendron is derived from a compound selected from the group consisting of HS-CH₂-CH₂-OH, HS- (CH₂) ₁₋₃-CO₂H and HS-CH₂-CH (OH) -CH₂-OH. Claim 46: A method of releasing the agrochemical amphiphilic hybrid system according to any of the preceding claims, comprising the step of contacting a plant or the surroundings of the plant with the amphiphilic hybrid release system and an enzyme or a pH adjusting agent in an amount effective to induce excision of the cleavable hydrophobic terminal group, thus disassembling said micelle. Claim 47: A kit for releasing the agrochemical amphiphilic hybrid system according to any of the preceding claims, comprising in one compartment the agrochemical amphiphilic hybrid system and in a second compartment an enzyme or a pH adjusting agent capable of hydrolyzing the group hydrophobic terminal cleavable so as to disassemble said micelle.

ARP150100557A 2014-09-09 2015-02-25 PEG-DENDRÓN HYBRID BASED AGROCHEMICAL RELEASE SYSTEM WHICH RESPONDS TO ENZYMES OR pH AR100763A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462047679P 2014-09-09 2014-09-09

Publications (1)

Publication Number Publication Date
AR100763A1 true AR100763A1 (en) 2016-11-02

Family

ID=55458417

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100557A AR100763A1 (en) 2014-09-09 2015-02-25 PEG-DENDRÓN HYBRID BASED AGROCHEMICAL RELEASE SYSTEM WHICH RESPONDS TO ENZYMES OR pH

Country Status (9)

Country Link
US (1) US20170245492A1 (en)
EP (1) EP3190880A4 (en)
CN (1) CN107072193A (en)
AR (1) AR100763A1 (en)
AU (1) AU2015313797A1 (en)
BR (1) BR112017004738A2 (en)
CA (1) CA2960592A1 (en)
IL (1) IL250845A0 (en)
WO (1) WO2016038596A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10869939B2 (en) 2015-08-03 2020-12-22 Ramot At Tel-Aviv University Ltd. Delivery system in micellar form having modular spectral response based on enzyme-responsive amphiphilic PEG-dendron hybrid polymers
KR20190051656A (en) * 2017-11-07 2019-05-15 삼성전자주식회사 Composition for etching, method of etching silicon nitride layer, and method for manufacturing semiconductor device
CN108078924B (en) * 2017-12-07 2020-06-02 同济大学 Preparation method of polyethylene glycol-modified pH-responsive nano micelle or vesicle with high drug loading capacity
CN109453364B (en) * 2018-09-30 2021-10-15 郑州大学第一附属医院 Dual-responsiveness nanoparticle and application thereof in tumor inhibition
WO2021091400A1 (en) 2019-11-08 2021-05-14 Donaghys Limited A composition and related methods of manufacture and use
CN113801508B (en) * 2020-06-12 2022-08-30 威高集团有限公司 Antibacterial coating with phosphatase response function, functional material with antibacterial coating and preparation method thereof
CN114441458B (en) * 2021-05-24 2023-06-09 中国科学院海洋研究所 Application of ZIF material in inhibition of mimic enzyme
CN113637657B (en) * 2021-08-05 2024-01-30 云南师范大学 Carboxylesterase CarCB2 and whole-cell catalyst and application thereof
CN114158551B (en) * 2021-11-22 2022-09-30 定远众邦生物工程有限公司 Nano pesticide preparation capable of rapidly responding to weak alkaline environment, preparation method and application thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL128775A (en) * 1994-03-07 2001-05-20 Dow Chemical Co Composition comprising a dendritic polymer in complex with at least one unit of biological response modifier and a process for the preparation thereof
WO2002077037A2 (en) * 2001-03-22 2002-10-03 The Administrators Of The Tulane Educational Fund Biaryl monomers and dendritic polymers derived therefrom
US20050226934A1 (en) * 2001-09-28 2005-10-13 Solubest Ltd. Inclusion complexes of active compounds in acrylate (co)polymers and methods for their production
WO2004019993A1 (en) * 2002-08-30 2004-03-11 Ramot At Tel Aviv University Ltd. Self-immolative dendrimers releasing many active moieties upon a single activating event
US7985424B2 (en) * 2004-04-20 2011-07-26 Dendritic Nanotechnologies Inc. Dendritic polymers with enhanced amplification and interior functionality
US20060269480A1 (en) * 2005-05-31 2006-11-30 Ramot At Tel Aviv University Ltd. Multi-triggered self-immolative dendritic compounds
US8685417B2 (en) * 2006-12-20 2014-04-01 Arkema, Inc. Polymer encapsulation and/or binding
EP2493291B1 (en) * 2009-10-26 2019-05-22 Dendritic Nanotechnologies, Inc. Peham dendrimers for use in agriculture
WO2011140376A1 (en) * 2010-05-05 2011-11-10 Prolynx Llc Controlled drug release from dendrimers
EP2678042B1 (en) * 2011-02-23 2018-05-09 The Board of Trustees of the University of Illionis Amphiphilic dendron-coils, micelles thereof and uses
WO2013096388A1 (en) * 2011-12-21 2013-06-27 The Regents Of The University Of California Telodendrimers with enhanced drug delivery
CN106687142A (en) * 2014-09-09 2017-05-17 雷蒙特亚特特拉维夫大学有限公司 Micelar delivery system based on enzyme-responsive amphiphilic PEG-dendron hybrid

Also Published As

Publication number Publication date
CA2960592A1 (en) 2016-03-17
IL250845A0 (en) 2017-04-30
EP3190880A4 (en) 2018-04-18
WO2016038596A1 (en) 2016-03-17
EP3190880A1 (en) 2017-07-19
AU2015313797A1 (en) 2017-03-30
BR112017004738A2 (en) 2017-12-05
US20170245492A1 (en) 2017-08-31
CN107072193A (en) 2017-08-18

Similar Documents

Publication Publication Date Title
AR100763A1 (en) PEG-DENDRÓN HYBRID BASED AGROCHEMICAL RELEASE SYSTEM WHICH RESPONDS TO ENZYMES OR pH
ES2981548T3 (en) Method for targeted alteration of DNA in plant cells
BR112017022045A2 (en) composition and kits for pseudoplastic microgel arrays
CL2019001447A1 (en) Preparation of solid cyclodextrin complexes for the supply of ophthalmic active pharmaceutical ingredients.
WO2011039637A3 (en) Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
WO2012170889A8 (en) Cleavable lipids
GB2442374A (en) Crosslinkable polymer compositions
BR112018071221A2 (en) compositions and methods for programming therapeutic cells using targeted nucleic acid nanocarriers
BR112014004460A2 (en) polymeric material for an insulated container
BR112013006341A2 (en) liquid agricultural formulations with improved stability
BRPI1105992B8 (en) SKIN CLEANSING COMPOSITION
WO2012153193A3 (en) Protein-active agent conjugates and method for preparing the same
WO2018039629A3 (en) Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2011110894A3 (en) A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition
BR112022003021A2 (en) MODIFICATION OF LIPID LOADED PLANT MESSENGER PACKAGES
BR112018007546A2 (en) three-dimensional prolapse relief device and system
AR097330A1 (en) HELPFUL COMBINATION
MX352187B (en) Composition of dexibuprofen transdermal hydrogel.
EP3838978A3 (en) Nucleated crystallization of poly(trimethylene-2,5-furandicarboxylate) (ptf) and articles made therefrom
BR112012031463A2 (en) composition comprising an agrochemical efficacy enhancing agent, agrochemical composition, agrochemical product preparation, method for cultivating an agricultural product, method for improving an agrochemical product, use of the composition comprising an agrochemical efficacy enhancing agent, use of a composition agrochemical
BR112013000394B8 (en) Immunogenic composition, use thereof and method of preparing said composition
ECSP17059101A (en) ACID COMPOSITION BASED ON LEONARDITE AND AMINO ACIDS
SA518400706B1 (en) Hydrophobized nanoparticles as breaker for viscoelastic surfactant gelled fluids
BR112015022780A2 (en) chemical crosslinkers
BR112018014277A2 (en) formulation, and method of preparing an injectable solution of an axl-adc

Legal Events

Date Code Title Description
FB Suspension of granting procedure