AR100679A1 - TRI-SPECIFIC ANTIBODIES - Google Patents
TRI-SPECIFIC ANTIBODIESInfo
- Publication number
- AR100679A1 AR100679A1 ARP150101705A ARP150101705A AR100679A1 AR 100679 A1 AR100679 A1 AR 100679A1 AR P150101705 A ARP150101705 A AR P150101705A AR P150101705 A ARP150101705 A AR P150101705A AR 100679 A1 AR100679 A1 AR 100679A1
- Authority
- AR
- Argentina
- Prior art keywords
- epitopes
- tri
- binding
- bind
- specific antibodies
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente se relaciona con las moléculas de unión tri-específicas, que son moléculas de polipéptido de cadena múltiple que poseen tres dominios de unión y, son por tanto capaces de mediar la unión coordinada a los tres epítopos. Los dominios de unión pueden seleccionarse de manera que las moléculas de unión tri-específicas son capaces de unirse a cualquiera de los tres diferentes epítopos. Los epítopos pueden ser epítopos del mismo antígeno o epítopos de dos o tres diferentes antígenos. En una modalidad preferida uno de los epítopos será capaz de unirse a CD3, el segundo de los epítopos será capaz de unirse a CD8 y el tercero de los epítopos será capaz de unirse a un epítopo de un antígeno asociado con la enfermedad. También se proporciona un anticuerpo de unión a ROR1 (antígeno de células cancerosas), así como derivados de los mismos y usos de tales composiciones.This is related to tri-specific binding molecules, which are multi-chain polypeptide molecules that possess three binding domains and are therefore capable of mediating coordinated binding to all three epitopes. Binding domains can be selected such that tri-specific binding molecules are capable of binding to any of the three different epitopes. The epitopes can be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment one of the epitopes will be able to bind to CD3, the second of the epitopes will be able to bind to CD8 and the third of the epitopes will be able to bind to an epitope of an antigen associated with the disease. An antibody to ROR1 (cancer cell antigen), as well as derivatives thereof and uses of such compositions is also provided.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462004571P | 2014-05-29 | 2014-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100679A1 true AR100679A1 (en) | 2016-10-26 |
Family
ID=58699843
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101708A AR100682A1 (en) | 2014-05-29 | 2015-05-29 | TRI-SPECIFIC UNION MOLECULES THAT SPECIFICALLY JOIN VARIOUS CANCER ANTIGENS AND METHODS OF USE OF THE SAME |
| ARP150101705A AR100679A1 (en) | 2014-05-29 | 2015-05-29 | TRI-SPECIFIC ANTIBODIES |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101708A AR100682A1 (en) | 2014-05-29 | 2015-05-29 | TRI-SPECIFIC UNION MOLECULES THAT SPECIFICALLY JOIN VARIOUS CANCER ANTIGENS AND METHODS OF USE OF THE SAME |
Country Status (1)
| Country | Link |
|---|---|
| AR (2) | AR100682A1 (en) |
-
2015
- 2015-05-29 AR ARP150101708A patent/AR100682A1/en unknown
- 2015-05-29 AR ARP150101705A patent/AR100679A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR100682A1 (en) | 2016-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |