AR100608A1 - CITOMEGALOVIRUS COMPLEXES AND USES OF THE SAME - Google Patents
CITOMEGALOVIRUS COMPLEXES AND USES OF THE SAMEInfo
- Publication number
- AR100608A1 AR100608A1 ARP150101642A ARP150101642A AR100608A1 AR 100608 A1 AR100608 A1 AR 100608A1 AR P150101642 A ARP150101642 A AR P150101642A AR P150101642 A ARP150101642 A AR P150101642A AR 100608 A1 AR100608 A1 AR 100608A1
- Authority
- AR
- Argentina
- Prior art keywords
- complexes
- citomegalovirus
- same
- pentameric
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16151—Methods of production or purification of viral material
Abstract
La presente divulgación proporciona proteínas gL de citomegalovirus (CMV) modificadas y complejos que comprenden proteínas gL, en particular complejos pentaméricos que comprenden gH, gL, pUL128, pUL130, pUL131. La divulgación también proporciona procedimientos de purificación de complejos pentaméricos y de reducción de complejos diméricos contaminantes que consisten en gH y gL. También se proporcionan usos de complejos pentaméricos en composiciones inmunógenas y vacunas.The present disclosure provides modified cytomegalovirus (CMV) gL proteins and complexes comprising gL proteins, in particular pentameric complexes comprising gH, gL, pUL128, pUL130, pUL131. The disclosure also provides procedures for purification of pentameric complexes and reduction of contaminating dimeric complexes consisting of gH and gL. Uses of pentameric complexes in immunogenic compositions and vaccines are also provided.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14170137 | 2014-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR100608A1 true AR100608A1 (en) | 2016-10-19 |
Family
ID=50884237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150101642A AR100608A1 (en) | 2014-05-27 | 2015-05-26 | CITOMEGALOVIRUS COMPLEXES AND USES OF THE SAME |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR100608A1 (en) |
BE (1) | BE1023213B1 (en) |
WO (1) | WO2015181142A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3364981A4 (en) | 2015-10-22 | 2019-08-07 | ModernaTX, Inc. | Human cytomegalovirus vaccine |
US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
JP6980780B2 (en) | 2016-10-21 | 2021-12-15 | モデルナティーエックス, インコーポレイテッド | Human cytomegalovirus vaccine |
WO2018193307A1 (en) | 2017-04-19 | 2018-10-25 | Glaxosmithkline Biologicals Sa | Modified cytomegalovirus proteins and stabilized complexes |
MX2021004273A (en) | 2018-10-17 | 2021-12-10 | Glaxosmithkline Biologicals Sa | Modified cytomegalovirus proteins and stabilized complexes. |
US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
TWI810589B (en) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | Human cytomegalovirus gb polypeptide |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
-
2015
- 2015-05-26 BE BE2015/5327A patent/BE1023213B1/en not_active IP Right Cessation
- 2015-05-26 AR ARP150101642A patent/AR100608A1/en unknown
- 2015-05-26 WO PCT/EP2015/061546 patent/WO2015181142A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
BE1023213B1 (en) | 2016-12-21 |
WO2015181142A1 (en) | 2015-12-03 |
BE1023213A1 (en) | 2016-12-21 |
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Legal Events
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FB | Suspension of granting procedure |