AR099880A1 - NICOTINAMIDE DERIVATIVES AS TRPA1 MODULATORS - Google Patents

NICOTINAMIDE DERIVATIVES AS TRPA1 MODULATORS

Info

Publication number
AR099880A1
AR099880A1 ARP150100930A ARP150100930A AR099880A1 AR 099880 A1 AR099880 A1 AR 099880A1 AR P150100930 A ARP150100930 A AR P150100930A AR P150100930 A ARP150100930 A AR P150100930A AR 099880 A1 AR099880 A1 AR 099880A1
Authority
AR
Argentina
Prior art keywords
trpa1
nicotinamide derivatives
modulators
trpa1 modulators
cycloalkyl
Prior art date
Application number
ARP150100930A
Other languages
Spanish (es)
Inventor
Holm Patrik
Vesalainen Anniina
Arvela Riina
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of AR099880A1 publication Critical patent/AR099880A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Exhiben actividad moduladora de TRPA1 y que por lo tanto son útiles como moduladores de TRPA1. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1) ó (2) donde; R¹ es cicloalquilo C₄₋₆ o fenilo, donde dicho cicloalquilo C₄₋₆ o fenilo no está sustituido o está sustituido con 1 ó 2 sustituyente(s) donde cada uno es en forma independiente halógeno, alcoxi C₁₋₂, o CN; y R² es H o halógeno; o una sal farmacéuticamente aceptable del mismo.They exhibit modulatory activity of TRPA1 and are therefore useful as modulators of TRPA1. Claim 1: A compound characterized in that it is of formula (1) or (2) wherein; R¹ is C₄₋₆ cycloalkyl or phenyl, wherein said C₄₋₆ cycloalkyl or phenyl is not substituted or substituted with 1 or 2 substituent (s) where each is independently halogen, C₁₋₂ alkoxy, or CN; and R² is H or halogen; or a pharmaceutically acceptable salt thereof.

ARP150100930A 2014-03-28 2015-03-27 NICOTINAMIDE DERIVATIVES AS TRPA1 MODULATORS AR099880A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20140092 2014-03-28

Publications (1)

Publication Number Publication Date
AR099880A1 true AR099880A1 (en) 2016-08-24

Family

ID=53005579

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100930A AR099880A1 (en) 2014-03-28 2015-03-27 NICOTINAMIDE DERIVATIVES AS TRPA1 MODULATORS

Country Status (3)

Country Link
AR (1) AR099880A1 (en)
TW (1) TW201620876A (en)
WO (1) WO2015144976A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2884922C (en) * 2012-10-01 2020-11-10 Orion Corporation N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists
CA3036571C (en) * 2016-09-12 2023-10-03 Neuralstem, Inc. Amelioration of neural deficits associated with diabetes
FR3114235A1 (en) 2020-09-18 2022-03-25 Université Grenoble Alpes INHIBITION OF ASTROCYTIC TRPA1 CHANNEL AS A NEW NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE
IT202100015098A1 (en) 2021-06-09 2022-12-09 Flonext S R L TRPA1 CHANNEL ANTAGONIST COMPOUND FOR USE IN DEGENERATIVE DISEASES OF THE RETINA

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280707A1 (en) * 2008-05-05 2011-02-09 Allergan, Inc. Alpha2b and alpha2c agonists
CA2884922C (en) * 2012-10-01 2020-11-10 Orion Corporation N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists

Also Published As

Publication number Publication date
TW201620876A (en) 2016-06-16
WO2015144976A1 (en) 2015-10-01

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