AR099671A1 - ANHIBINE OF INHIBINE a, CODIFYING GENE OF INHIBINE a, CODIFYING GENE OF FUSION PROTEIN, PROCESS OF OBTAINING THE INHIBINE ANTIGEN a, ANTIGEN COMPOSITION, USE OF THE INHIBINE ANTIGEN a AND USE OF THE ANTIGEN COMPOSITION - Google Patents

ANHIBINE OF INHIBINE a, CODIFYING GENE OF INHIBINE a, CODIFYING GENE OF FUSION PROTEIN, PROCESS OF OBTAINING THE INHIBINE ANTIGEN a, ANTIGEN COMPOSITION, USE OF THE INHIBINE ANTIGEN a AND USE OF THE ANTIGEN COMPOSITION

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Publication number
AR099671A1
AR099671A1 ARP150100658A ARP150100658A AR099671A1 AR 099671 A1 AR099671 A1 AR 099671A1 AR P150100658 A ARP150100658 A AR P150100658A AR P150100658 A ARP150100658 A AR P150100658A AR 099671 A1 AR099671 A1 AR 099671A1
Authority
AR
Argentina
Prior art keywords
inhibine
antigen
inhibin
fusion protein
composition
Prior art date
Application number
ARP150100658A
Other languages
Spanish (es)
Inventor
Marroquin Quelopana Miryam
Raul Romero Ramos Celso
Original Assignee
Ouro Fino Saúde Animal Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ouro Fino Saúde Animal Ltda filed Critical Ouro Fino Saúde Animal Ltda
Publication of AR099671A1 publication Critical patent/AR099671A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a una proteína inhibina a modificada, sus fragmentos antigénicos y proteína de fusión comprendiendo la misma, así como a una composición antigénica comprendiendo inhibina a modificada y/o un fragmento antigénico de la misma y/o una proteína de fusión comprendiendo inhibina a modificada, al proceso de producción de la proteína inhibina a modificada, sus fragmentos antigénicos y proteína de fusión comprendiendo la misma, y al uso de la inhibina a modificada, sus fragmentos antigénicos; o proteína de fusión comprendiendo inhibina a, y al uso de la composición antigénica en el aumento de la ovulación de animales, especialmente mamíferos y aves. La presente se fundamenta en la modificación de la secuencia madura de la subunidad a de la inhibina de Bos taurus, específicamente en el segmento de la extremidad C-terminal que, además de la modificación de algunos aminoácidos, pasa a tener las dos regiones más inmunogénicas en ese segmento. Gen codificante.This refers to an inhibin to modified protein, its antigenic fragments and fusion protein comprising the same, as well as to an antigenic composition comprising inhibin to modified and / or an antigenic fragment thereof and / or a fusion protein comprising inhibin. to modified, to the process of production of the inhibin to modified protein, its antigenic fragments and fusion protein comprising the same, and to the use of the inhibin to modified, its antigenic fragments; or fusion protein comprising inhibin a, and the use of the antigenic composition in the increase of ovulation of animals, especially mammals and birds. This is based on the modification of the mature sequence of the a subunit of Bos taurus inhibin, specifically in the segment of the C-terminal limb that, in addition to the modification of some amino acids, happens to have the two most immunogenic regions in that segment. Coding gene.

ARP150100658A 2014-03-07 2015-03-05 ANHIBINE OF INHIBINE a, CODIFYING GENE OF INHIBINE a, CODIFYING GENE OF FUSION PROTEIN, PROCESS OF OBTAINING THE INHIBINE ANTIGEN a, ANTIGEN COMPOSITION, USE OF THE INHIBINE ANTIGEN a AND USE OF THE ANTIGEN COMPOSITION AR099671A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR102014005376A BR102014005376A2 (en) 2014-03-07 2014-03-07 inhibin alpha antigen, inhibin alpha coding gene, fusion protein encoding gene, process of obtaining inhibin alpha antigen, antigenic composition, use of inhibin alpha antigen, and use of antigenic composition

Publications (1)

Publication Number Publication Date
AR099671A1 true AR099671A1 (en) 2016-08-10

Family

ID=54054284

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100658A AR099671A1 (en) 2014-03-07 2015-03-05 ANHIBINE OF INHIBINE a, CODIFYING GENE OF INHIBINE a, CODIFYING GENE OF FUSION PROTEIN, PROCESS OF OBTAINING THE INHIBINE ANTIGEN a, ANTIGEN COMPOSITION, USE OF THE INHIBINE ANTIGEN a AND USE OF THE ANTIGEN COMPOSITION

Country Status (4)

Country Link
AR (1) AR099671A1 (en)
BR (1) BR102014005376A2 (en)
UY (1) UY36020A (en)
WO (1) WO2015131254A1 (en)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341617C (en) * 1984-06-08 2011-06-28 Henry George Burger Inhibin isolated from ovarian follicular fluid
WO1986006076A1 (en) * 1985-04-18 1986-10-23 Biotechnology Australia Pty. Ltd. Recombinant inhibin
US5215893A (en) * 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
NZ231899A (en) * 1985-10-03 1991-07-26 Genentech Inc Human or porcine inhibin peptide compositions and dna encoding them
US4864019A (en) * 1985-11-08 1989-09-05 The Salk Institute For Biological Studies Antibodies to inhibin and conjugates produced therefrom
ES2065673T3 (en) * 1990-01-08 1995-02-16 Genentech Inc PROCEDURE TO INCREASE FERTILITY IN FEMALES.
EP0804219B1 (en) * 1994-02-28 2002-07-17 Agritech Technologies, Ltd. Inhibin compositions and methods of use thereof
US20040220098A1 (en) * 1994-02-28 2004-11-04 Satterlee Daniel G. Inhibin compositions and methods of enhancing fertility and growth
JPH07238097A (en) * 1994-09-07 1995-09-12 Masao Igarashi Igg antibody comprising inhibin as antigen
JP2899534B2 (en) * 1994-12-09 1999-06-02 全国農業協同組合連合会 Method of inducing superovulation in cattle
JP2006523180A (en) * 2002-11-07 2006-10-12 アグリテック テクノロジー リミテッド Novel inhibin-related multi-antigen peptide composition that promotes productivity in birds
BRPI0506043A (en) * 2005-07-12 2007-03-13 Univ Fed Do Rio Grande Do Sul animal evaluation and selection process
CN101407781A (en) * 2008-12-01 2009-04-15 华中农业大学 Inhibin DNA vaccine capable of improving animal fertility, and preparation and use thereof

Also Published As

Publication number Publication date
UY36020A (en) 2015-09-30
BR102014005376A2 (en) 2016-02-10
WO2015131254A1 (en) 2015-09-11

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