AR098785A2 - DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTS - Google Patents

DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTS

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Publication number
AR098785A2
AR098785A2 ARP140104705A ARP140104705A AR098785A2 AR 098785 A2 AR098785 A2 AR 098785A2 AR P140104705 A ARP140104705 A AR P140104705A AR P140104705 A ARP140104705 A AR P140104705A AR 098785 A2 AR098785 A2 AR 098785A2
Authority
AR
Argentina
Prior art keywords
receptors
derivatives
andonergic
bifenyl
agonists
Prior art date
Application number
ARP140104705A
Other languages
Spanish (es)
Inventor
Mammen Mathai
Dunham Sarah
Hughes Adam
Husfeld Craig
Lee Tae
Stangeland Eric
Chen Yan
Original Assignee
Theravance Respiratory Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Respiratory Co Llc filed Critical Theravance Respiratory Co Llc
Publication of AR098785A2 publication Critical patent/AR098785A2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Los derivados de bifenilo presentan actividad agonista de los receptores adrenérgicos b₂ y actividad antagonista de los receptores muscarínicos, y, por consiguiente, dichos derivados de bifenilo son útiles para tratar trastornos pulmonares, tales como la enfermedad obstructiva pulmonar crónica y asma. Reivindicación 1: Un compuesto caracterizado porque es 1-[2-(2-cloro-4-{[(R)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxi-fenilcarbamil)etil]piperidin-4-il éster de ácido bifenil-2-ilcarbámico de fórmula (1) o una sal farmacéuticamente aceptable del mismo.Biphenyl derivatives have b₂ adrenergic receptor agonist activity and muscarinic receptor antagonist activity, and, therefore, said biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma. Claim 1: A compound characterized in that it is 1- [2- (2-chloro-4 - {[(R) -2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl ) ethylamino] methyl} -5-methoxy-phenylcarbamil) ethyl] piperidin-4-yl ester of biphenyl-2-ylcarbamic acid of formula (1) or a pharmaceutically acceptable salt thereof.

ARP140104705A 2003-02-14 2014-12-17 DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTS AR098785A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44784303P 2003-02-14 2003-02-14

Publications (1)

Publication Number Publication Date
AR098785A2 true AR098785A2 (en) 2016-06-15

Family

ID=36703992

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140104705A AR098785A2 (en) 2003-02-14 2014-12-17 DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTS

Country Status (4)

Country Link
CN (5) CN100378092C (en)
AR (1) AR098785A2 (en)
ES (1) ES2351392T3 (en)
ZA (1) ZA200506215B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263623B2 (en) * 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
AU2010238504B2 (en) * 2009-04-14 2015-04-16 Theravance Biopharma R&D Ip, Llc Process for the preparation of a biphenyl-2-ylcarbamic acid ester
HUE042975T2 (en) * 2009-04-23 2019-07-29 Theravance Respiratory Co Llc Diamide compounds having muscarinic receptor antagonist and beta 2 adrenergic receptor agonist activity
EP2426121A4 (en) * 2009-04-30 2012-10-31 Teijin Pharma Ltd Quaternary ammonium salt compound
CN104876854B (en) * 2015-04-16 2017-03-01 御盛隆堂药业有限责任公司 Hydroxy acetate derivative and application thereof
CN107108502A (en) * 2015-05-14 2017-08-29 四川海思科制药有限公司 With β2Biphenyl derivatives of receptor agonism and m receptor antagonistic activity and its in purposes pharmaceutically
EP3375781A4 (en) * 2015-07-21 2019-01-09 Sichuan Haisco Pharmaceutical Co., Ltd. Benzo ring derivative with b2 receptor agonist and m3 receptor antagonist activities and use thereof in medicine
BR112018015018A2 (en) * 2016-01-22 2018-12-18 Sichuan Haisco Pharmaceutical Co Ltd azacycle starch derivative, method of preparation thereof, and pharmaceutical application
WO2019015639A1 (en) * 2017-07-21 2019-01-24 四川海思科制药有限公司 Azacyclic amide derivative composition and preparation thereof
WO2019015640A1 (en) * 2017-07-21 2019-01-24 四川海思科制药有限公司 Salt of azacyclic amide derivative, crystal form thereof and preparation method therefor and use thereof
CN108794395B (en) * 2018-07-06 2021-04-20 大连理工大学 Preparation method of 2-quinolinone compounds
CN111423434A (en) * 2019-01-09 2020-07-17 四川海思科制药有限公司 Carbonamide derivative and preparation method thereof
CN113801029A (en) * 2020-06-16 2021-12-17 盈科瑞（天津）创新医药研究有限公司 Preparation method of levalbuterol hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541669B1 (en) * 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
UA73543C2 (en) * 1999-12-07 2005-08-15 Тераванс, Інк. Urea derivatives, a pharmaceutical composition and use of derivative in the preparation of medicament for the treatment of disease being mediated by muscarine receptor
ATE299494T1 (en) * 1999-12-07 2005-07-15 Theravance Inc CARBAMAT DERIVATIVES AS MUSCARINE RECEPTOR ANTONISTS

Also Published As

Publication number Publication date
ES2351392T3 (en) 2011-02-03
CN101239971B (en) 2011-07-20
CN101239968B (en) 2011-07-20
CN101239969A (en) 2008-08-13
CN101239968A (en) 2008-08-13
CN101239970B (en) 2011-07-20
ZA200506215B (en) 2006-06-28
CN100378092C (en) 2008-04-02
CN1759108A (en) 2006-04-12
CN101239970A (en) 2008-08-13
CN101239969B (en) 2011-07-20
CN101239971A (en) 2008-08-13

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