AR098785A2 - DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTS - Google Patents
DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTSInfo
- Publication number
- AR098785A2 AR098785A2 ARP140104705A ARP140104705A AR098785A2 AR 098785 A2 AR098785 A2 AR 098785A2 AR P140104705 A ARP140104705 A AR P140104705A AR P140104705 A ARP140104705 A AR P140104705A AR 098785 A2 AR098785 A2 AR 098785A2
- Authority
- AR
- Argentina
- Prior art keywords
- receptors
- derivatives
- andonergic
- bifenyl
- agonists
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Los derivados de bifenilo presentan actividad agonista de los receptores adrenérgicos b₂ y actividad antagonista de los receptores muscarínicos, y, por consiguiente, dichos derivados de bifenilo son útiles para tratar trastornos pulmonares, tales como la enfermedad obstructiva pulmonar crónica y asma. Reivindicación 1: Un compuesto caracterizado porque es 1-[2-(2-cloro-4-{[(R)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxi-fenilcarbamil)etil]piperidin-4-il éster de ácido bifenil-2-ilcarbámico de fórmula (1) o una sal farmacéuticamente aceptable del mismo.Biphenyl derivatives have b₂ adrenergic receptor agonist activity and muscarinic receptor antagonist activity, and, therefore, said biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma. Claim 1: A compound characterized in that it is 1- [2- (2-chloro-4 - {[(R) -2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl ) ethylamino] methyl} -5-methoxy-phenylcarbamil) ethyl] piperidin-4-yl ester of biphenyl-2-ylcarbamic acid of formula (1) or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44784303P | 2003-02-14 | 2003-02-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR098785A2 true AR098785A2 (en) | 2016-06-15 |
Family
ID=36703992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140104705A AR098785A2 (en) | 2003-02-14 | 2014-12-17 | DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTS |
Country Status (4)
Country | Link |
---|---|
CN (5) | CN100378092C (en) |
AR (1) | AR098785A2 (en) |
ES (1) | ES2351392T3 (en) |
ZA (1) | ZA200506215B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8263623B2 (en) * | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
AU2010238504B2 (en) * | 2009-04-14 | 2015-04-16 | Theravance Biopharma R&D Ip, Llc | Process for the preparation of a biphenyl-2-ylcarbamic acid ester |
HUE042975T2 (en) * | 2009-04-23 | 2019-07-29 | Theravance Respiratory Co Llc | Diamide compounds having muscarinic receptor antagonist and beta 2 adrenergic receptor agonist activity |
EP2426121A4 (en) * | 2009-04-30 | 2012-10-31 | Teijin Pharma Ltd | Quaternary ammonium salt compound |
CN104876854B (en) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | Hydroxy acetate derivative and application thereof |
CN107108502A (en) * | 2015-05-14 | 2017-08-29 | 四川海思科制药有限公司 | With β2Biphenyl derivatives of receptor agonism and m receptor antagonistic activity and its in purposes pharmaceutically |
EP3375781A4 (en) * | 2015-07-21 | 2019-01-09 | Sichuan Haisco Pharmaceutical Co., Ltd. | Benzo ring derivative with b2 receptor agonist and m3 receptor antagonist activities and use thereof in medicine |
BR112018015018A2 (en) * | 2016-01-22 | 2018-12-18 | Sichuan Haisco Pharmaceutical Co Ltd | azacycle starch derivative, method of preparation thereof, and pharmaceutical application |
WO2019015639A1 (en) * | 2017-07-21 | 2019-01-24 | 四川海思科制药有限公司 | Azacyclic amide derivative composition and preparation thereof |
WO2019015640A1 (en) * | 2017-07-21 | 2019-01-24 | 四川海思科制药有限公司 | Salt of azacyclic amide derivative, crystal form thereof and preparation method therefor and use thereof |
CN108794395B (en) * | 2018-07-06 | 2021-04-20 | 大连理工大学 | Preparation method of 2-quinolinone compounds |
CN111423434A (en) * | 2019-01-09 | 2020-07-17 | 四川海思科制药有限公司 | Carbonamide derivative and preparation method thereof |
CN113801029A (en) * | 2020-06-16 | 2021-12-17 | 盈科瑞(天津)创新医药研究有限公司 | Preparation method of levalbuterol hydrochloride |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
UA73543C2 (en) * | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Urea derivatives, a pharmaceutical composition and use of derivative in the preparation of medicament for the treatment of disease being mediated by muscarine receptor |
ATE299494T1 (en) * | 1999-12-07 | 2005-07-15 | Theravance Inc | CARBAMAT DERIVATIVES AS MUSCARINE RECEPTOR ANTONISTS |
-
2004
- 2004-02-13 CN CNB2004800065284A patent/CN100378092C/en not_active Expired - Lifetime
- 2004-02-13 CN CN2008100741569A patent/CN101239968B/en not_active Expired - Lifetime
- 2004-02-13 CN CN2008100741573A patent/CN101239969B/en not_active Expired - Lifetime
- 2004-02-13 ES ES04711253T patent/ES2351392T3/en not_active Expired - Lifetime
- 2004-02-13 CN CN2008100741592A patent/CN101239970B/en not_active Expired - Lifetime
- 2004-02-13 CN CN2008100741605A patent/CN101239971B/en not_active Expired - Lifetime
-
2005
- 2005-08-03 ZA ZA200506215A patent/ZA200506215B/en unknown
-
2014
- 2014-12-17 AR ARP140104705A patent/AR098785A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES2351392T3 (en) | 2011-02-03 |
CN101239971B (en) | 2011-07-20 |
CN101239968B (en) | 2011-07-20 |
CN101239969A (en) | 2008-08-13 |
CN101239968A (en) | 2008-08-13 |
CN101239970B (en) | 2011-07-20 |
ZA200506215B (en) | 2006-06-28 |
CN100378092C (en) | 2008-04-02 |
CN1759108A (en) | 2006-04-12 |
CN101239970A (en) | 2008-08-13 |
CN101239969B (en) | 2011-07-20 |
CN101239971A (en) | 2008-08-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR098785A2 (en) | DERIVATIVES OF BIFENYL ANDONERGIC RECEPTORS AGONISTS b₂ AND MUSCARINIC RECEPTORS ANTAGONISTS | |
NZ595850A (en) | DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND Beta2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | |
US6410792B1 (en) | Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists | |
KR20010033169A (en) | Aminophenoxyacetic acid derivatives as neuroprotectants | |
BRPI0707559B8 (en) | form I polymorph of the succinic acid salt of 1-[2-(2-chloro-4-{[(r)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5) - yl) ethylamino]methyl]}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester of biphenyl-2-yl-carbamic acid, its preparation process and uses | |
HK1106227A1 (en) | Crystalline form of a biphenyl compound | |
SK19512000A3 (en) | 4-BENZYL PIPERIDINE ALKYLSULFOXIDE HETEROCYCLES AND THEIR USE ASì (54) SUBTYPE-SELECTIVE NMDA RECEPTOR ANTAGONISTS | |
Layton et al. | Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists | |
US6534525B1 (en) | 2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists | |
WO2004074246A3 (en) | Biphenyl derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity | |
TW430663B (en) | Novel substituted piperidines useful for the treatment of allergic diseases | |
WO2007112322A3 (en) | Indole compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity | |
EA013123B1 (en) | Substituted indole compounds having nos inhibitory activity | |
EA200700027A1 (en) | GLUCAGON RECEPTOR ANTAGONISTS, THEIR RECEIVING AND THERAPEUTIC APPLICATION | |
ATE459619T1 (en) | GLUCAGON RECEPTOR ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | |
PE20130215A1 (en) | NEW DERIVATIVES OF CYCLOHEXYLAMINE THAT HAVE ACTIVITY AS BETA2 ADRENERGIC AGONISTS AND AS MUSCARINIC ANTAGONISTS M3 | |
WO2002005819A1 (en) | Compounds and methods | |
WO2007127196A3 (en) | DIALKYLPHENYL COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | |
AR072262A1 (en) | COMBINATION -408, WHICH INCLUDES N-CICLOHEXIL-N3- [2- (3-FLUOROPHENYL) ETIL] -N- (2 - {[2- (4-HIDROXI-2-OXO-2,3-DIHIDRO-1,3 -BENZOTIAZOL-7-IL) ETIL] AMINO} ETIL- beta-ALANINAMIDA.USO. METHOD. SET OF ELEMENTS. PHARMACEUTICAL COMPOSITION. INTERMEDIARY. | |
ATE473961T1 (en) | GLUCAGON RECEPTOR ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | |
KR20070038503A (en) | New heterocyclic carboxylic acid amide derivatives | |
EA200601461A1 (en) | NEW DERIVATIVES BENZIL (IDEN) LACTAM | |
WO2007121389A3 (en) | 4,4-disubstituted piperidine derivatives as nk-i and serotonin transporter inhibitors | |
PE20081386A1 (en) | 4-IMIDAZOLINES AS TAAR BINDERS | |
BRPI0411603A (en) | 4- (Aminomethyl) piperidine benzamides as antagonists 5ht4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |