AR097217A1 - IMMUNOGEN COMBINATION COMPOSITIONS - Google Patents
IMMUNOGEN COMBINATION COMPOSITIONSInfo
- Publication number
- AR097217A1 AR097217A1 ARP140102924A ARP140102924A AR097217A1 AR 097217 A1 AR097217 A1 AR 097217A1 AR P140102924 A ARP140102924 A AR P140102924A AR P140102924 A ARP140102924 A AR P140102924A AR 097217 A1 AR097217 A1 AR 097217A1
- Authority
- AR
- Argentina
- Prior art keywords
- pertussis
- rsv
- conjugated
- carrier protein
- capsular saccharide
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Abstract
Se divulgan composiciones inmunógenas de combinación que pueden provocar protección frente a infección y enfermedad tanto de VRS como de B. pertussis. Más específicamente, esta divulgación se refiere a dichas composiciones que comprenden un análogo recombinante de proteína F de VRS, junto con antígenos acelulares (Pa) o de célula entera (Pw) de B. pertussis y al uso de los mismos, en particular en el contexto de inmunización neonatal y materna. También se divulgan regímenes de vacunas, procedimientos, así como usos, y kits, de composiciones inmunógenas para proteger a lactantes frente a enfermedad provocada por VRS y B. pertussis por inmunización materna. Reivindicación 62: La composición inmunógena de combinación de la reivindicación 61, que comprende uno o más antígenos seleccionados del grupo que consiste en: toxoide diftérico (D); toxoide tetánico (T); antígeno de superficie de Hepatitis B (HBsAg); virus poliomelítico inactivado (IPV); sacárido capsular de H. influenzae tipo b (Hib) conjugado a una proteína vehículo; sacárido capsular de N. meningitidis tipo C conjugado a una proteína vehículo; sacárido capsular de N. meningitidis tipo Y conjugado a una proteína vehículo; sacárido capsular de N. meningitidis tipo A conjugado a una proteína vehículo; sacárido capsular de N. meningitidis tipo W conjugado a una proteína vehículo; y un antígeno de N. meningitidis tipo B. Reivindicación 107: Un kit que comprende una pluralidad de composiciones inmunógenas formuladas para la administración a una hembra preñada, en el que el kit comprende: (a) una primera composición inmunógena que comprende un análogo de proteína F puede inducir, provocar o reforzar una respuesta inmunitaria humoral específica para VRS; y (b) una segunda composición inmunógena que comprende al menos un antígeno de B. pertussis que puede inducir, provocar o reforzar una respuesta humoral específica para B. pertussis, en donde después de la administración a una hembra preñada, las primera y la segunda composiciones inmunógenas inducen, provocan o refuerzan al menos un subconjunto de anticuerpos específicos de VRS y al menos un subconjunto de anticuerpos específicos de B. pertussis, anticuerpos que se transfieren por medio de la placenta a un bebé en gestación de la hembra preñada, protegiendo así al lactante frente a infección o enfermedad provocada por VRS y B. pertussis.Combined immunogenic compositions that can cause protection against infection and disease of both RSV and B. pertussis are disclosed. More specifically, this disclosure relates to said compositions comprising a recombinant analog of RSV F protein, together with acellular (Pa) or whole cell (Pw) antigens of B. pertussis and their use, in particular in the context of neonatal and maternal immunization. Vaccine regimens, procedures, as well as uses, and kits of immunogenic compositions to protect infants against disease caused by RSV and B. pertussis by maternal immunization are also disclosed. Claim 62: The combination immunogenic composition of claim 61, comprising one or more antigens selected from the group consisting of: diphtheria toxoid (D); tetanus toxoid (T); Hepatitis B surface antigen (HBsAg); inactivated polyomelitic virus (IPV); capsular saccharide of H. influenzae type b (Hib) conjugated to a carrier protein; capsular saccharide of N. meningitidis type C conjugated to a carrier protein; capsular saccharide of N. meningitidis type Y conjugated to a carrier protein; capsular saccharide of N. meningitidis type A conjugated to a carrier protein; capsular saccharide of N. meningitidis type W conjugated to a carrier protein; and an N. meningitidis type B antigen. Claim 107: A kit comprising a plurality of immunogenic compositions formulated for administration to a pregnant female, wherein the kit comprises: (a) a first immunogenic composition comprising an analogue of F protein can induce, elicit or strengthen a humoral immune response specific to RSV; and (b) a second immunogenic composition comprising at least one B. pertussis antigen that can induce, elicit or reinforce a specific humoral response for B. pertussis, wherein after administration to a pregnant female, the first and second Immunogenic compositions induce, provoke or reinforce at least a subset of RSV-specific antibodies and at least a subset of B. pertussis-specific antibodies, antibodies that are transferred through the placenta to a pregnant baby of the pregnant female, thus protecting the infant against infection or disease caused by RSV and B. pertussis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1313990.2A GB201313990D0 (en) | 2013-08-05 | 2013-08-05 | Combination immunogenic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
AR097217A1 true AR097217A1 (en) | 2016-02-24 |
Family
ID=49224176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140102924A AR097217A1 (en) | 2013-08-05 | 2014-08-04 | IMMUNOGEN COMBINATION COMPOSITIONS |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR097217A1 (en) |
GB (1) | GB201313990D0 (en) |
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2013
- 2013-08-05 GB GBGB1313990.2A patent/GB201313990D0/en not_active Ceased
-
2014
- 2014-08-04 AR ARP140102924A patent/AR097217A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB201313990D0 (en) | 2013-09-18 |
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