AR095526A1 - COATED PHENYLEFRINE PARTICLES AND USE OF THESE IN PHARMACEUTICAL FORMULATIONS - Google Patents
COATED PHENYLEFRINE PARTICLES AND USE OF THESE IN PHARMACEUTICAL FORMULATIONSInfo
- Publication number
- AR095526A1 AR095526A1 ARP140101134A ARP140101134A AR095526A1 AR 095526 A1 AR095526 A1 AR 095526A1 AR P140101134 A ARP140101134 A AR P140101134A AR P140101134 A ARP140101134 A AR P140101134A AR 095526 A1 AR095526 A1 AR 095526A1
- Authority
- AR
- Argentina
- Prior art keywords
- extended
- phenylefrine
- particles
- coated
- pharmaceutical formulations
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000013265 extended release Methods 0.000 abstract 4
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 abstract 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract 3
- 229920001577 copolymer Polymers 0.000 abstract 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 abstract 3
- 239000001856 Ethyl cellulose Substances 0.000 abstract 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 2
- 229920002472 Starch Polymers 0.000 abstract 2
- 239000011247 coating layer Substances 0.000 abstract 2
- 229920001249 ethyl cellulose Polymers 0.000 abstract 2
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 2
- 229960001802 phenylephrine Drugs 0.000 abstract 2
- 239000008107 starch Substances 0.000 abstract 2
- 235000019698 starch Nutrition 0.000 abstract 2
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Reivindicación 1: Una partícula de liberación prolongada, en donde la partícula de liberación prolongada comprende almidón, fenilefrina, y acrilato de etilo y copolímero de metacrilato de metilo, en donde el almidón, fenilefrina, y acrilato de etilo y copolímero de metacrilato de metilo se recubren con por lo menos dos capas de recubrimiento. Reivindicación 2: La partícula de liberación prolongada de la reivindicación 1, en donde una primera capa de recubrimiento comprende etilcelulosa, citrato de acetiltributilo y estearato magnésico. Reivindicación 3: La partícula de liberación prolongada de la reivindicación 2, en donde una segunda capa de recubrimiento comprende copolímero de acrilato de etilo y metacrilato de metilo y dispersión acuosa de etilcelulosa.Claim 1: An extended-release particle, wherein the extended-release particle comprises starch, phenylephrine, and ethyl acrylate and copolymer of methyl methacrylate, wherein starch, phenylephrine, and ethyl acrylate and copolymer of methyl methacrylate are They cover with at least two layers of coating. Claim 2: The extended release particle of claim 1, wherein a first coating layer comprises ethyl cellulose, acetyltributyl citrate and magnesium stearate. Claim 3: The extended-release particle of claim 2, wherein a second coating layer comprises copolymer of ethyl acrylate and methyl methacrylate and aqueous dispersion of ethyl cellulose.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/832,797 US20140271893A1 (en) | 2013-03-15 | 2013-03-15 | Coated phenylephrine particles and use thereof in pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095526A1 true AR095526A1 (en) | 2015-10-21 |
Family
ID=50288314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101134A AR095526A1 (en) | 2013-03-15 | 2014-03-14 | COATED PHENYLEFRINE PARTICLES AND USE OF THESE IN PHARMACEUTICAL FORMULATIONS |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20140271893A1 (en) |
| EP (1) | EP2968188B1 (en) |
| JP (1) | JP6373957B2 (en) |
| CN (1) | CN105246466B (en) |
| AR (1) | AR095526A1 (en) |
| AU (1) | AU2014238062B2 (en) |
| BR (1) | BR112015022945B1 (en) |
| CA (1) | CA2906363C (en) |
| HK (1) | HK1219886A1 (en) |
| IL (1) | IL241051B (en) |
| MX (1) | MX2015012635A (en) |
| NZ (1) | NZ712318A (en) |
| PH (1) | PH12015502015A1 (en) |
| RU (1) | RU2681312C2 (en) |
| SA (1) | SA515361065B1 (en) |
| UA (1) | UA120251C2 (en) |
| WO (1) | WO2014149529A1 (en) |
| ZA (1) | ZA201507676B (en) |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990332A (en) | 1958-04-02 | 1961-06-27 | Wallace & Tiernan Inc | Pharmaceutical preparations comprising cation exchange resin adsorption compounds and treatment therewith |
| US4221778A (en) | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
| GB8707421D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
| CA2269679A1 (en) | 1996-12-20 | 1998-07-02 | Warner-Lambert Company | Antitussive drugs delivered by partially coated ion exchange resins |
| GEP20043285B (en) * | 2000-03-30 | 2004-07-26 | Bristol Myers Squibb Co | Sustained Release Beadlets Containing Stavudine, Method for Their Production, Pharmaceutical Composition Containing the Same and Use Thereof for Treatment Retroviral Infections |
| US20030190343A1 (en) * | 2002-03-05 | 2003-10-09 | Pfizer Inc. | Palatable pharmaceutical compositions for companion animals |
| US9492541B2 (en) | 2004-09-14 | 2016-11-15 | Sovereign Pharmaceuticals, Llc | Phenylepherine containing dosage form |
| US20050266032A1 (en) | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
| US7639628B2 (en) | 2005-07-14 | 2009-12-29 | University Of Notre Dame Du Lac | Response time detection in a network having shared interfaces |
| DK2018160T3 (en) | 2006-03-16 | 2012-02-06 | Tris Pharma Inc | Modified depot formulations containing drug-ion exchange resin complexes |
| NZ573174A (en) | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
| KR101464771B1 (en) | 2006-06-01 | 2014-11-26 | 머크 샤프 앤드 돔 코포레이션 | Pharmaceutical compositions for sustained release of phenylephrine |
| RU2009101309A (en) * | 2006-06-19 | 2010-07-27 | МакНЕЙЛ-ППС, ИНК. (US) | PARTICULAR COATED PARTICLES CONTAINING AN ACTIVE INGREDIENT |
| CN101534795B (en) | 2006-11-21 | 2013-04-03 | 麦克内尔-Ppc股份有限公司 | Modified release analgesic suspensions |
| US9833510B2 (en) * | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
| CA2729015A1 (en) * | 2008-06-26 | 2009-12-30 | Mcneil-Ppc, Inc. | Coated particles containing pharmaceutically active agents |
| CA2805974C (en) * | 2010-08-13 | 2019-11-26 | Euro-Celtique S.A. | Use of binders for manufacturing storage stable formulations |
| RU2477741C1 (en) * | 2012-04-27 | 2013-03-20 | Юрий Васильевич Захаров | Mulching composition (versions) |
-
2013
- 2013-03-15 US US13/832,797 patent/US20140271893A1/en not_active Abandoned
-
2014
- 2014-02-28 MX MX2015012635A patent/MX2015012635A/en active IP Right Grant
- 2014-02-28 WO PCT/US2014/019311 patent/WO2014149529A1/en active Application Filing
- 2014-02-28 UA UAA201510099A patent/UA120251C2/en unknown
- 2014-02-28 BR BR112015022945-0A patent/BR112015022945B1/en active IP Right Grant
- 2014-02-28 AU AU2014238062A patent/AU2014238062B2/en active Active
- 2014-02-28 NZ NZ712318A patent/NZ712318A/en not_active IP Right Cessation
- 2014-02-28 EP EP14710734.6A patent/EP2968188B1/en active Active
- 2014-02-28 CN CN201480015804.7A patent/CN105246466B/en not_active Expired - Fee Related
- 2014-02-28 RU RU2015144045A patent/RU2681312C2/en active
- 2014-02-28 JP JP2016500494A patent/JP6373957B2/en active Active
- 2014-02-28 CA CA2906363A patent/CA2906363C/en active Active
- 2014-03-14 AR ARP140101134A patent/AR095526A1/en unknown
-
2015
- 2015-09-02 IL IL241051A patent/IL241051B/en active IP Right Grant
- 2015-09-09 PH PH12015502015A patent/PH12015502015A1/en unknown
- 2015-09-13 SA SA515361065A patent/SA515361065B1/en unknown
- 2015-10-14 ZA ZA2015/07676A patent/ZA201507676B/en unknown
-
2016
- 2016-07-07 HK HK16107943.5A patent/HK1219886A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1219886A1 (en) | 2017-04-21 |
| ZA201507676B (en) | 2017-11-29 |
| SA515361065B1 (en) | 2017-02-02 |
| CN105246466B (en) | 2018-03-30 |
| BR112015022945A2 (en) | 2017-07-18 |
| UA120251C2 (en) | 2019-11-11 |
| RU2681312C2 (en) | 2019-03-06 |
| JP2016516029A (en) | 2016-06-02 |
| AU2014238062A1 (en) | 2015-09-17 |
| RU2015144045A (en) | 2017-04-20 |
| IL241051B (en) | 2018-06-28 |
| MX2015012635A (en) | 2016-08-03 |
| EP2968188B1 (en) | 2017-04-19 |
| EP2968188A1 (en) | 2016-01-20 |
| NZ712318A (en) | 2020-05-29 |
| WO2014149529A1 (en) | 2014-09-25 |
| JP6373957B2 (en) | 2018-08-15 |
| CN105246466A (en) | 2016-01-13 |
| US20140271893A1 (en) | 2014-09-18 |
| CA2906363C (en) | 2021-03-16 |
| PH12015502015B1 (en) | 2016-01-11 |
| CA2906363A1 (en) | 2014-09-25 |
| BR112015022945B1 (en) | 2022-11-01 |
| PH12015502015A1 (en) | 2016-01-11 |
| IL241051A0 (en) | 2015-11-30 |
| AU2014238062B2 (en) | 2018-11-29 |
| BR112015022945A8 (en) | 2022-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| USD734329S1 (en) | Electronic device | |
| JP2012528718A5 (en) | ||
| EA201591821A1 (en) | PROTECTED FROM UNAUTHORIZED USE PHARMACEUTICAL COMPOSITIONS | |
| USD710829S1 (en) | Speaker grille | |
| JP2019526543A5 (en) | ||
| JP2015519422A5 (en) | ||
| CL2013003524A1 (en) | Absorbent core comprising absorbent material with base weight that varies across the core and comprises an absorbent structure that includes a substrate layer and an absorbent layer with absorbent material; disposable absorbent article. | |
| USD730869S1 (en) | Speaker | |
| JP2015515063A5 (en) | ||
| CL2013000718A1 (en) | An inclusion complex comprising a) a cyclodextrin, b) fulvestrant and c) a carrier; its method of preparation; formulation and dosage form comprising the complex; preparation comprising the complex or formulation; and its use in the treatment of cancer and systemic lupus erythematosus, among other diseases. | |
| ES2527276T3 (en) | Balloon with coated surface | |
| ECSP17075052A (en) | Ribociclib tablet | |
| USD712809S1 (en) | Disk brake friction lining retaining device | |
| USD734079S1 (en) | Lectern | |
| JP2015513329A5 (en) | How to determine hand hygiene compliance | |
| TW201614677A (en) | Composition comprising silver nanowires and styrene/(meth)acrylic copolymers for the preparation of electroconductive transparent layers | |
| CU20150178A7 (en) | FORMULATION IN PEARLS OF DELAYED CISTEAMINE RELEASE | |
| PH12016502350A1 (en) | Absorbent article | |
| BR112012022363A2 (en) | modified release dosage form | |
| TR201202948A2 (en) | Tablet formulation comprising dapaglyphlosin and prolonged release metaphormin. | |
| JP2015508411A5 (en) | ||
| CR20150145A (en) | COMPOSITIONS WITH HOT Fused RESIN MATRIX | |
| USD761418S1 (en) | Absorbent article with a pattern | |
| JP2015009701A5 (en) | ||
| AR095526A1 (en) | COATED PHENYLEFRINE PARTICLES AND USE OF THESE IN PHARMACEUTICAL FORMULATIONS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |