AR094866A1 - CRYSTAL FORMS OF AN INHIBITOR OF PROLIL HYDROXYLASE - Google Patents
CRYSTAL FORMS OF AN INHIBITOR OF PROLIL HYDROXYLASEInfo
- Publication number
- AR094866A1 AR094866A1 ARP140100570A ARP140100570A AR094866A1 AR 094866 A1 AR094866 A1 AR 094866A1 AR P140100570 A ARP140100570 A AR P140100570A AR P140100570 A ARP140100570 A AR P140100570A AR 094866 A1 AR094866 A1 AR 094866A1
- Authority
- AR
- Argentina
- Prior art keywords
- prolil
- hydroxylase
- inhibitor
- crystal forms
- isoquinoline
- Prior art date
Links
- 102000008109 Mixed Function Oxygenases Human genes 0.000 title 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- YOZBGTLTNGAVFU-UHFFFAOYSA-N roxadustat Chemical compound C1=C2C(C)=NC(C(=O)NCC(O)=O)=C(O)C2=CC=C1OC1=CC=CC=C1 YOZBGTLTNGAVFU-UHFFFAOYSA-N 0.000 abstract 2
- 229940126062 Compound A Drugs 0.000 abstract 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente divulgación se relaciona con las formas sólidas cristalinas del ácido [(4-hidroxi-1-metil-7-fenoxi-isoquinolina-3-carbonil)-amino]-acético, con el proceso de preparación de las formas, así como con las composiciones farmacéuticas y los métodos de uso de las mismas. compuestos útiles para tratar casos de anemia, isquemia e hipoxia. Reivindicación 1: Ácido [(4-hidroxi-1-metil-7-fenoxi-isoquinolina-3-carbonil)-amino]-acético cristalino (Compuesto A - Forma A) caracterizado por un difractograma de rayos X de polvo que comprende los siguientes picos: 8,5, 16,2, y 27,4 º2q ± 0,2 º2q.The present disclosure relates to the crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl) -amino] -acetic acid, with the process of preparing the forms, as well as with pharmaceutical compositions and methods of use thereof. compounds useful for treating cases of anemia, ischemia and hypoxia. Claim 1: Crystalline [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl) -amino] -acetic acid (Compound A - Form A) characterized by a powder X-ray diffractogram comprising the following peaks: 8.5, 16.2, and 27.4 º2q ± 0.2 º2q.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768297P | 2013-02-22 | 2013-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094866A1 true AR094866A1 (en) | 2015-09-02 |
Family
ID=56119049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100570A AR094866A1 (en) | 2013-02-22 | 2014-02-24 | CRYSTAL FORMS OF AN INHIBITOR OF PROLIL HYDROXYLASE |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR094866A1 (en) |
-
2014
- 2014-02-24 AR ARP140100570A patent/AR094866A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |