AR091678A1 - POSITIVE ALLOSTERIC MODULAR NICOTINIC ACETILCOLINE RECEIVER - Google Patents

POSITIVE ALLOSTERIC MODULAR NICOTINIC ACETILCOLINE RECEIVER

Info

Publication number
AR091678A1
AR091678A1 ARP130102396A AR091678A1 AR 091678 A1 AR091678 A1 AR 091678A1 AR P130102396 A ARP130102396 A AR P130102396A AR 091678 A1 AR091678 A1 AR 091678A1
Authority
AR
Argentina
Prior art keywords
positive allosteric
nicotinic
acetilcoline
receiver
modular
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/063219 external-priority patent/WO2013007621A1/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR091678A1 publication Critical patent/AR091678A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos mencionados son moduladores alostéricos positivos (PAM) del receptor nicotínico de acetilcolina a7. Reivindicación 1: Un compuesto de acuerdo con la fórmula (1) en donde R¹, R², R³, R⁴ y R⁵ son H; R⁶ es metoximetilo; A⁷ es C-R⁷, A⁸ es N y A⁹ es C-R⁹; R⁷, R⁹, R¹⁰ y R¹¹ se seleccionan independientemente entre sí de H, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆ y OR¹²; en donde R¹² representa un resto de anillo saturado monocíclico que tiene 4 - 6 átomos de anillo en donde uno de dichos átomos de anillo es O y el resto es C; y sales farmacéuticamente aceptables de los mismos.The compounds mentioned are positive allosteric modulators (PAM) of the nicotinic acetylcholine a7 receptor. Claim 1: A compound according to formula (1) wherein R¹, R², R³, R⁴ and R⁵ are H; R⁶ is methoxymethyl; A⁷ is C-R⁷, A⁸ is N and A⁹ is C-R⁹; R⁷, R⁹, R¹⁰ and R¹¹ are independently selected from each other of H, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy and OR¹²; wherein R¹² represents a monocyclic saturated ring moiety having 4-6 ring atoms where one of said ring atoms is O and the rest is C; and pharmaceutically acceptable salts thereof.

ARP130102396 2012-07-06 2013-07-05 POSITIVE ALLOSTERIC MODULAR NICOTINIC ACETILCOLINE RECEIVER AR091678A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2012/063219 WO2013007621A1 (en) 2011-07-08 2012-07-06 Positive allosteric modulators of nicotinic acetylcholine receptor

Publications (1)

Publication Number Publication Date
AR091678A1 true AR091678A1 (en) 2015-02-18

Family

ID=48745970

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP130102397 AR091679A1 (en) 2012-07-06 2013-07-05 POSITIVE ALLOSTERIC MODULAR NICOTINIC ACETILCOLINE RECEIVER
ARP130102396 AR091678A1 (en) 2012-07-06 2013-07-05 POSITIVE ALLOSTERIC MODULAR NICOTINIC ACETILCOLINE RECEIVER

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP130102397 AR091679A1 (en) 2012-07-06 2013-07-05 POSITIVE ALLOSTERIC MODULAR NICOTINIC ACETILCOLINE RECEIVER

Country Status (2)

Country Link
AR (2) AR091679A1 (en)
WO (2) WO2014006120A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018011453A (en) 2016-03-22 2019-01-10 Merck Sharp & Dohme Allosteric modulators of nicotinic acetylcholine receptors.
CA3098583C (en) 2018-05-01 2023-05-16 Merck Sharp & Dohme Corp. Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008307195B2 (en) 2007-10-04 2012-11-22 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof
CA2761639C (en) 2009-05-29 2016-06-07 Raqualia Pharma Inc. Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
US8497271B2 (en) * 2009-10-07 2013-07-30 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
UA111746C2 (en) 2011-07-08 2016-06-10 Х. Луннбек А/С POSITIVE Allosteric Modulators of the Nicotinic Acetylcholine Receptor

Also Published As

Publication number Publication date
WO2014006117A1 (en) 2014-01-09
AR091679A1 (en) 2015-02-18
WO2014006120A1 (en) 2014-01-09

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