AR087875A1 - PROCESS FOR THE ELABORATION OF PIRIDAZINE DERIVATIVES AS ANTIBIOTICS SYNTHESIS INTERMEDIARIES - Google Patents

PROCESS FOR THE ELABORATION OF PIRIDAZINE DERIVATIVES AS ANTIBIOTICS SYNTHESIS INTERMEDIARIES

Info

Publication number
AR087875A1
AR087875A1 ARP120103393A ARP120103393A AR087875A1 AR 087875 A1 AR087875 A1 AR 087875A1 AR P120103393 A ARP120103393 A AR P120103393A AR P120103393 A ARP120103393 A AR P120103393A AR 087875 A1 AR087875 A1 AR 087875A1
Authority
AR
Argentina
Prior art keywords
compound
oxatiino
pyridazin
dihydro
formula
Prior art date
Application number
ARP120103393A
Other languages
Spanish (es)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR087875A1 publication Critical patent/AR087875A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un intermediario de síntesis utilizado comúnmente en la preparación de compuestos antibióticos, o para la elaboración de sales de ese compuesto. La presente se relaciona asimismo con compuestos intermedios utilizados en dicho proceso, es decir 6,7-dihidro-[1,4]oxatiino[2,3-c]piridazin-3(2H)-ona, trifluorometansulfonato de 6,7-dihidro-[1,4]oxatiino[2 ,3-c]piridazin-3-ilo y 6,7-dihidro-[1,4]oxatiino[2,3-c]piridazin-3-carboxilato de metilo y con las sales del mismo. Reivindicación 1: El compuesto de la fórmula (1) o una sal de dicho compuesto. Reivindicación 2: Un proceso para la elaboración del compuesto de la fórmula (1) de acuerdo con lo definido en la reivindicación 1, donde dicho proceso comprende los siguientes dos pasos: a) la reacción del compuesto de la fórmula (2) con 2-mercaptoetanol en presencia de una base en un solvente aprótico polar o una mezcla aprótica polar de solventes y b) la reacción del intermediario obtenido después del paso a) anterior con trifenilfosfina y azodicarboxilato de diisopropilo o azodicarboxilato de dietilo en un solvente aprótico polar o una mezcla aprótica polar de solventes.A synthesis intermediate commonly used in the preparation of antibiotic compounds, or for the preparation of salts of that compound. This also relates to intermediate compounds used in said process, that is 6,7-dihydro- [1,4] oxatiino [2,3-c] pyridazin-3 (2H) -one, 6,7-dihydro trifluoromethanesulfonate - [1,4] oxatiino [2,3-c] pyridazin-3-yl and 6,7-dihydro- [1,4] oxatiino [2,3-c] pyridazin-3-carboxylic acid methyl ester and with salts of the same. Claim 1: The compound of the formula (1) or a salt of said compound. Claim 2: A process for the preparation of the compound of the formula (1) as defined in claim 1, wherein said process comprises the following two steps: a) the reaction of the compound of the formula (2) with 2- mercaptoethanol in the presence of a base in a polar aprotic solvent or a polar aprotic solvent mixture and b) the reaction of the intermediate obtained after step a) above with triphenylphosphine and diisopropyl azodicarboxylate or diethyl azodicarboxylate in a polar aprotic solvent or an aprotic mixture polar of solvents.

ARP120103393A 2011-09-16 2012-09-14 PROCESS FOR THE ELABORATION OF PIRIDAZINE DERIVATIVES AS ANTIBIOTICS SYNTHESIS INTERMEDIARIES AR087875A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2011054061 2011-09-16

Publications (1)

Publication Number Publication Date
AR087875A1 true AR087875A1 (en) 2014-04-23

Family

ID=47080755

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120103393A AR087875A1 (en) 2011-09-16 2012-09-14 PROCESS FOR THE ELABORATION OF PIRIDAZINE DERIVATIVES AS ANTIBIOTICS SYNTHESIS INTERMEDIARIES

Country Status (3)

Country Link
AR (1) AR087875A1 (en)
TW (1) TW201313726A (en)
WO (1) WO2013038374A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7413346B2 (en) 2019-03-06 2024-01-15 第一三共株式会社 Pyrrolopyrazole derivative

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1954697E (en) 2005-10-21 2010-05-17 Glaxo Group Ltd Peri condensed tricyclic compounds useful as antibacterial agents
JP2009520779A (en) 2005-12-22 2009-05-28 グラクソ グループ リミテッド Heterocyclic compounds, their production and their use as antibacterial agents
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
GB0705672D0 (en) 2007-03-23 2007-05-02 Glaxo Group Ltd Compounds
EP1980251A1 (en) 2007-04-13 2008-10-15 Glaxo Group Limited Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
ES1065649Y (en) 2007-06-22 2008-01-01 Gavalda Josep Sarmiento PERFECTED MOUTH OPENING PROVISION FOR ANIMALS
WO2009128953A2 (en) 2008-04-18 2009-10-22 University Of Maryland, Baltimore Genetic variants in a hypertension susceptibility gene stk39 and uses thereof
MX2011005905A (en) 2008-12-12 2011-06-20 Actelion Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives.
AR076222A1 (en) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd DERIVATIVES 2-HYDROXIETIL-1H-QUINOLIN-ONA AND ITS AZAISOTHERAL ANALOGS WITH ANTIBACTERIAL ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
WO2013038374A1 (en) 2013-03-21
TW201313726A (en) 2013-04-01

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