AR085770A1 - ANTIBIOTIC COMPOUNDS DERIVED FROM HOMOERITHROMYCIN AND PHARMACEUTICAL COMPOSITIONS - Google Patents

ANTIBIOTIC COMPOUNDS DERIVED FROM HOMOERITHROMYCIN AND PHARMACEUTICAL COMPOSITIONS

Info

Publication number
AR085770A1
AR085770A1 ARP120101099A ARP120101099A AR085770A1 AR 085770 A1 AR085770 A1 AR 085770A1 AR P120101099 A ARP120101099 A AR P120101099A AR P120101099 A ARP120101099 A AR P120101099A AR 085770 A1 AR085770 A1 AR 085770A1
Authority
AR
Argentina
Prior art keywords
hydrogen
hydrocarbyl
group
homoerithromycin
pharmaceutical compositions
Prior art date
Application number
ARP120101099A
Other languages
Spanish (es)
Inventor
Wang Shouming
Dauvergne Jerome
Original Assignee
Norbrook Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norbrook Lab Ltd filed Critical Norbrook Lab Ltd
Publication of AR085770A1 publication Critical patent/AR085770A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a un compuesto que tiene la fórmula (1) o a su derivado farmacéuticamente aceptable: en donde se observa lo siguiente: R es hidrógeno, hidrocarbilo o -(CH₂)ₙC(X)ZᵇRᵃ, en donde n oscila entre 0 y 10, b es 0 ó 1, Z es -N- o -O-, y Rᵃ es hidrógeno o un grupo hidrocarbilo que está opcionalmente sustituido con un sustituyente con contenido de heteroátomos; X es O o S y ya sea R y R, con el átomo de N intermedio, conforman conjuntamente un anillo o R es hidrógeno o alquilo C₁₋₆ y R es -(CH₂)ᵈYₑR¹; en donde se observa lo siguiente: R¹ es hidrógeno o hidrocarbilo; Y es -U(CH₂)ᵛB-, -U(CH₂)ᵛ- o a grupo heterocíclico, tal como los seleccionados del grupo de fórmulas (2); U y B son, en forma independiente un radical divalente seleccionado entre -N(R²)-, -O-, -S(O)ᶻ-, -N(R²)C(O)-, -C(O)N(R²)-, -C(O)O- y -N[C(O)R²]-; d es un número entero entre 0 y 10; e es 0 ó 1; v oscila entre 0 y 8 y R² es hidrógeno o un grupo hidrocarbilo que está opcionalmente sustituido con un grupo funcional con contenido de heteroátomos.This refers to a compound having the formula (1) or its pharmaceutically acceptable derivative: where the following is observed: R is hydrogen, hydrocarbyl or - (CH₂) ₙC (X) ZᵇRᵃ, where n ranges from 0 to 10, b is 0 or 1, Z is -N- or -O-, and Rᵃ is hydrogen or a hydrocarbyl group that is optionally substituted with a heteroatom-containing substituent; X is O or S and either R and R, with the intermediate N atom, together form a ring or R is hydrogen or C₁₋₆ alkyl and R is - (CH₂) ᵈYₑR¹; where the following is observed: R¹ is hydrogen or hydrocarbyl; Y is -U (CH₂) ᵛB-, -U (CH₂) ᵛ- or a heterocyclic group, such as those selected from the group of formulas (2); U and B are independently a divalent radical selected from -N (R²) -, -O-, -S (O) ᶻ-, -N (R²) C (O) -, -C (O) N ( R²) -, -C (O) O- and -N [C (O) R²] -; d is an integer between 0 and 10; e is 0 or 1; v ranges from 0 to 8 and R² is hydrogen or a hydrocarbyl group that is optionally substituted with a functional group containing heteroatoms.

ARP120101099A 2011-04-01 2012-03-30 ANTIBIOTIC COMPOUNDS DERIVED FROM HOMOERITHROMYCIN AND PHARMACEUTICAL COMPOSITIONS AR085770A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1105633.0A GB201105633D0 (en) 2011-04-01 2011-04-01 Antibotic compounds

Publications (1)

Publication Number Publication Date
AR085770A1 true AR085770A1 (en) 2013-10-23

Family

ID=44071883

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101099A AR085770A1 (en) 2011-04-01 2012-03-30 ANTIBIOTIC COMPOUNDS DERIVED FROM HOMOERITHROMYCIN AND PHARMACEUTICAL COMPOSITIONS

Country Status (3)

Country Link
AR (1) AR085770A1 (en)
GB (1) GB201105633D0 (en)
WO (1) WO2012131396A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2908620A1 (en) 2013-04-10 2014-10-16 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
CN104119413B (en) * 2014-07-29 2016-08-24 华中农业大学 A kind of soil draws the synthetic method of mycin residual marker
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
WO2023139163A1 (en) * 2022-01-19 2023-07-27 Awakn Ls Europe Holdings Limited 1,3-benzodioxole esters and their therapeutic use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472372B1 (en) * 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials

Also Published As

Publication number Publication date
WO2012131396A1 (en) 2012-10-04
GB201105633D0 (en) 2011-05-18

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