AR082806A1 - STABLE PHARMACEUTICAL COMPOSITION - Google Patents

STABLE PHARMACEUTICAL COMPOSITION

Info

Publication number
AR082806A1
AR082806A1 ARP110103162A ARP110103162A AR082806A1 AR 082806 A1 AR082806 A1 AR 082806A1 AR P110103162 A ARP110103162 A AR P110103162A AR P110103162 A ARP110103162 A AR P110103162A AR 082806 A1 AR082806 A1 AR 082806A1
Authority
AR
Argentina
Prior art keywords
water
similar structural
pharmaceutical composition
insoluble
active ingredient
Prior art date
Application number
ARP110103162A
Other languages
Spanish (es)
Inventor
Ajay Jaysingh Khopade
Subhas Balaram Bhowmick
N Arulsudar
Bhushan Shrikant Borole
Original Assignee
Sun Pharma Advanced Res Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Res Co Ltd filed Critical Sun Pharma Advanced Res Co Ltd
Publication of AR082806A1 publication Critical patent/AR082806A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición farmacéutica en la forma de una solución que comprende ingrediente insoluble en el agua con eficacia terapéutica y un análogo estructural similar del ingrediente activo insoluble en el agua, uno o más excipientes de aceptación farmacéutica y uno o más disolventes miscibles en el agua donde el ingrediente activo insoluble en el agua está presente en cantidades de eficacia terapéutica y el análogo estructural similar está presente en cantidades suficientes de tal modo que cuando se añade la composición a un vehículo acuoso, la misma forma una nanodispersión adecuada para infusión intravenosa donde dicha nanodispersión es estable durante períodos más largos en comparación con una dispersión formada a partir de una composición idéntica pero desprovista del análogo estructural similar del ingrediente activo insoluble en el agua.Reivindicación 4: Una composición farmacéutica de conformidad con la reivindicación 1, en el cual el ingrediente de actividad terapéutica insoluble en el agua es SN-38 y el análogo estructural similar es irinotecán. Reivindicación 6: Una composición farmacéutica de conformidad con la reivindicación 1, en la cual el ingrediente activo de actividad terapéutica insoluble en el agua es docetaxel y el análogo estructural similar es paclitaxel.A pharmaceutical composition in the form of a solution comprising water insoluble ingredient with therapeutic efficacy and a similar structural analogue of the water insoluble active ingredient, one or more pharmaceutical acceptance excipients and one or more water miscible solvents where the Water-insoluble active ingredient is present in amounts of therapeutic efficacy and the similar structural analog is present in sufficient amounts such that when the composition is added to an aqueous vehicle, it forms a nanodispersion suitable for intravenous infusion where said nanodispersion is stable for longer periods compared to a dispersion formed from an identical composition but devoid of the similar structural analogue of the water-insoluble active ingredient. Claim 4: A pharmaceutical composition according to claim 1, wherein the ingredient of act Water-insoluble therapeutic activity is SN-38 and the similar structural analog is irinotecan. Claim 6: A pharmaceutical composition according to claim 1, wherein the active ingredient of water insoluble therapeutic activity is docetaxel and the similar structural analog is paclitaxel.

ARP110103162A 2010-08-30 2011-08-30 STABLE PHARMACEUTICAL COMPOSITION AR082806A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2180MU2010 2010-08-30

Publications (1)

Publication Number Publication Date
AR082806A1 true AR082806A1 (en) 2013-01-09

Family

ID=45773329

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110103162A AR082806A1 (en) 2010-08-30 2011-08-30 STABLE PHARMACEUTICAL COMPOSITION

Country Status (3)

Country Link
AR (1) AR082806A1 (en)
TW (1) TW201215412A (en)
WO (1) WO2012029076A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201602258WA (en) * 2013-10-04 2016-04-28 Prolynx Llc Slow-release conjugates of sn-38
US20190209469A1 (en) * 2016-08-20 2019-07-11 Ftf Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
US11730836B2 (en) 2018-01-12 2023-08-22 Prolynx Llc Synergistic cancer treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001243515A1 (en) * 2000-03-08 2001-09-17 Rhode Island Hospital, A Lifespan Partner Combination drug therapy
EP2252269A1 (en) * 2008-02-11 2010-11-24 Technion Research and Development Foundation, Ltd. Casein particles encapsulating therapeutically active agents and uses thereof
US20100151037A1 (en) * 2008-08-07 2010-06-17 Yivan Jiang Method for the preparation of nanoparticles containing a poorly water-soluble pharmaceutically active compound
US20100203150A1 (en) * 2009-02-06 2010-08-12 National Tsing Hua University Novel amphiphilic copolymers and fabrication method thereof

Also Published As

Publication number Publication date
WO2012029076A3 (en) 2012-04-26
WO2012029076A2 (en) 2012-03-08
TW201215412A (en) 2012-04-16

Similar Documents

Publication Publication Date Title
PE20150997A1 (en) THERAPEUTIC NANOPARTICLES THAT INCLUDE A THERAPEUTIC AGENT AND METHODS TO MAKE THEM AND USE THEM
EP3682875A3 (en) Methods of treating pediatric metabolic syndrome
WO2011107749A3 (en) Pulsatile drug release
NZ702744A (en) D-amino acid compounds for liver disease
WO2011107755A3 (en) Immediate/delayed drug delivery
MY167691A (en) A pharmaceutical spray composition comprising a vitamin d analogue and a corticosteroid
WO2013156488A3 (en) Optimised subcutaneous therapeutic agents
SV2011003907A (en) ANTIMICROBIAL COMPOSITIONS
HRP20200704T1 (en) Aqueous formulation comprising paracetamol and ibuprofen
UA118576C2 (en) Pharmaceutical composition comprising brinzolamide
AR078283A1 (en) ORAL SUSPENSION FORMULATIONS OF DIBENZAZEPINA CARBOXAMIDAS
AR096854A1 (en) PHARMACEUTICAL COMPOSITION FOR A SUSTAINED RELEASE OF LANREOTIDE
MX359713B (en) Improved wound healing compositions comprising microspheres.
BR112012015437A2 (en) substantially anhydrous stable storage topical composition
AR082806A1 (en) STABLE PHARMACEUTICAL COMPOSITION
WO2012127277A3 (en) Bendamustine anionic-catioinic cyclopolysaccharide compositions
CA2688047A1 (en) Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration
WO2014043243A3 (en) Platinum compounds, compositions and methods for the treatment of cancer
IN2014DN10134A (en)
UY31669A1 (en) "PHARMACEUTICAL FORMULATION THAT INCLUDES OXABISPIDINS / 236"
JO3689B1 (en) Njectable formulations of paracetamol
AR093414A1 (en) CONSERVANT COMPOSITION WHICH CONSISTS OF A STABILIZED OXYCHLOR COMPLEX AND A POLYOL, AND TOPICAL COMPOSITION THAT INCLUDES IT
ES2530941T3 (en) Treatment and prevention of HIV infection
AR110595A1 (en) SYSTEM FOR THE DELIVERY OF LIQUID POLYMERS FOR THE PROLONGED ADMINISTRATION OF DRUGS
TH6662C3 (en) Melatonin injections

Legal Events

Date Code Title Description
FB Suspension of granting procedure