AR080860A1 - Formulacion farmaceutica a base de ibuprofeno y codeina de estabilidad mejorada - Google Patents
Formulacion farmaceutica a base de ibuprofeno y codeina de estabilidad mejoradaInfo
- Publication number
- AR080860A1 AR080860A1 ARP110101029A ARP110101029A AR080860A1 AR 080860 A1 AR080860 A1 AR 080860A1 AR P110101029 A ARP110101029 A AR P110101029A AR P110101029 A ARP110101029 A AR P110101029A AR 080860 A1 AR080860 A1 AR 080860A1
- Authority
- AR
- Argentina
- Prior art keywords
- ibuprofen
- pharmaceutical formulation
- improved stability
- codeine
- tablets
- Prior art date
Links
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 title abstract 5
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001680 ibuprofen Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229960004126 codeine Drugs 0.000 abstract 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229920003086 cellulose ether Polymers 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical group CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000005395 methacrylic acid group Chemical class 0.000 abstract 1
- 239000003605 opacifier Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Formulacion farmacéutica a base de ibuprofeno y codeína de estabilidad mejorada. La invencion consiste en una nueva formulacion farmacéutica en forma de comprimidos o similares que comprende un nucleo compuesto por una asociacion de ibuprofeno y codeína como ingredientes activos, junto con un excipiente que incluye al menos un diluyente, un agente disgregante, un agente fluidificante y un lubricante que es estearil fumarato sodico. Dicho nucleo se recubre con una composicion a base de uno o vanos polímeros de diversos éteres de celulosa modificada y polímeros derivados de los ácidos acrílico y metacrílico, un plastificante y, un opacificante o de color y cualquiera de sus mezclas. Estas características hacen a los comprimidos de la invencion más eficaces y seguros bajo la forma de preparados más estables, sin implicar este hecho una mayor complejidad tecnologica. Su uso y procedimiento de fabricacion.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201030479A ES2365961B1 (es) | 2010-03-30 | 2010-03-30 | Formulación farmacéutica a base de ibuprofeno y codeína de estabilidad mejorada. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR080860A1 true AR080860A1 (es) | 2012-05-16 |
Family
ID=44675991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110101029A AR080860A1 (es) | 2010-03-30 | 2011-03-29 | Formulacion farmaceutica a base de ibuprofeno y codeina de estabilidad mejorada |
Country Status (5)
Country | Link |
---|---|
US (1) | US20130064890A1 (es) |
EP (1) | EP2554164B1 (es) |
AR (1) | AR080860A1 (es) |
ES (2) | ES2365961B1 (es) |
WO (1) | WO2011121160A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112915089B (zh) * | 2021-02-02 | 2022-09-16 | 天津大学 | 一种布洛芬载利伐沙班功能性颗粒及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1261260A (en) | 1984-04-16 | 1989-09-26 | Anil Salpekar | Directly compressible codeine salt compositions |
GB8521350D0 (en) | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
GB8629567D0 (en) | 1986-12-10 | 1987-01-21 | Boots Co Plc | Therapeutic agents |
GB8905815D0 (en) | 1989-03-14 | 1989-04-26 | Beecham Group Plc | Medicament |
GB9121204D0 (en) | 1991-10-04 | 1991-11-20 | Euro Celtique Sa | Medicament |
RU2140782C1 (ru) | 1994-08-23 | 1999-11-10 | СмитКлайн Бичем ПЛК | Улучшенные фармацевтические препараты, содержащие ибупрофен и кодеин |
EP1670441A4 (en) * | 2003-10-07 | 2012-05-02 | Andrx Pharmaceuticals Llc | FAST RESOLUTION FORMULATION |
GB0519350D0 (en) * | 2005-09-22 | 2005-11-02 | Boots Healthcare Int Ltd | Therapeutic agents |
DE102008048729A1 (de) * | 2008-09-24 | 2010-03-25 | Add Technologies Ltd Advanced Drug Delivery | Multipartikuläre Tabletten und Verfahren zur deren Herstellung |
-
2010
- 2010-03-30 ES ES201030479A patent/ES2365961B1/es active Active
-
2011
- 2011-03-25 ES ES11762059T patent/ES2803430T3/es active Active
- 2011-03-25 EP EP11762059.1A patent/EP2554164B1/en active Active
- 2011-03-25 US US13/635,662 patent/US20130064890A1/en not_active Abandoned
- 2011-03-25 WO PCT/ES2011/070203 patent/WO2011121160A1/es active Application Filing
- 2011-03-29 AR ARP110101029A patent/AR080860A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20130064890A1 (en) | 2013-03-14 |
EP2554164B1 (en) | 2020-04-15 |
ES2365961A1 (es) | 2011-10-14 |
ES2803430T3 (es) | 2021-01-26 |
EP2554164A4 (en) | 2014-05-14 |
ES2365961B1 (es) | 2013-01-24 |
EP2554164A1 (en) | 2013-02-06 |
WO2011121160A1 (es) | 2011-10-06 |
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Legal Events
Date | Code | Title | Description |
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FC | Refusal |