AR080856A1 - USEFUL PIRAZOLOPIRIDINE COMPOUNDS AS QUINASE INHIBITORS - Google Patents

USEFUL PIRAZOLOPIRIDINE COMPOUNDS AS QUINASE INHIBITORS

Info

Publication number
AR080856A1
AR080856A1 ARP110100282A ARP110100282A AR080856A1 AR 080856 A1 AR080856 A1 AR 080856A1 AR P110100282 A ARP110100282 A AR P110100282A AR P110100282 A ARP110100282 A AR P110100282A AR 080856 A1 AR080856 A1 AR 080856A1
Authority
AR
Argentina
Prior art keywords
independently
absent
compounds
alkyl
pirazolopiridine
Prior art date
Application number
ARP110100282A
Other languages
Spanish (es)
Inventor
Christopher John Davis
Dean Boyall
Damien Fraysee
Juan Manuel Jimenez
Guy Brenchley
Julian M C Golec
Heather Twin
Stephen Young
Luca Settimo
Andrew W Miller
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR080856A1 publication Critical patent/AR080856A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composiciones farmacéuticamente aceptables que comprenden dichos compuestos y métodos para usar las composiciones en el tratamiento de varias enfermedades, condiciones o trastornos y procesos para preparar compuestos. Reivindicacion 1: Un compuesto representado por la formula estructural (1) o una sal farmacéuticamente aceptable del mismo, donde T es -NH- o está ausente, cada Jc1 y Jc2 es independientemente -CN, -F, -Cl, -OR, -CH2OR, o -CF3; cada U1, U2 y U3 es independientemente -H, Z, o Jb donde no más de uno entre U1, U2 y U3 es -H; o dos de U1, U2 y U3 se unen entre sí para formar un anillo de cicloalquilo C1-6 que tiene 0-1 heteroátomos independientemente sustituidos con uno o más Je; Z es Y2-Q2; Y2 está ausente o es alquilo C1-6 opcionalmente e independientemente sustituido con uno o más Jd; Q2 está ausente o es un cicloalquilo C3-8 que tiene 0-1 heteroátomos opcionalmente e independientemente substituido con uno o más Je, donde no ambos Y2 y Q2 están ausentes; cada Jb es independientemente -F, -OR, -CN, -CF3, -N(R)2, -C(O)N(R)2, alquilo C1-6 opcionalmente e independientemente substituido con uno o más Ja; cada Ja es independientemente -F, -OR, -N(R)2, o -C(O)N(R) 2; cada Jd es independientemente -OR, -CN, -C(O)N(R)2, -N(R)2 o F; cada Je es independientemente alquilo C1-6, -OR, - N(R)2CF3, o F; cada R es -H o alquilo C1-6; y donde existe un centro quiral en el átomo indicado por *.Pharmaceutically acceptable compositions comprising said compounds and methods for using the compositions in the treatment of various diseases, conditions or disorders and processes for preparing compounds. Claim 1: A compound represented by structural formula (1) or a pharmaceutically acceptable salt thereof, where T is -NH- or is absent, each Jc1 and Jc2 is independently -CN, -F, -Cl, -OR, - CH2OR, or -CF3; each U1, U2 and U3 is independently -H, Z, or Jb where no more than one between U1, U2 and U3 is -H; or two of U1, U2 and U3 join together to form a C1-6 cycloalkyl ring having 0-1 heteroatoms independently substituted with one or more Je; Z is Y2-Q2; Y2 is absent or is C1-6 alkyl optionally and independently substituted with one or more Jd; Q2 is absent or is a C3-8 cycloalkyl having 0-1 heteroatoms optionally and independently substituted with one or more Je, where not both Y2 and Q2 are absent; each Jb is independently -F, -OR, -CN, -CF3, -N (R) 2, -C (O) N (R) 2, C1-6 alkyl optionally and independently substituted with one or more Ja; each Ja is independently -F, -OR, -N (R) 2, or -C (O) N (R) 2; each Jd is independently -OR, -CN, -C (O) N (R) 2, -N (R) 2 or F; each Je is independently C1-6 alkyl, -OR, - N (R) 2CF3, or F; each R is -H or C1-6 alkyl; and where there is a chiral center in the atom indicated by *.

ARP110100282A 2010-01-27 2011-01-27 USEFUL PIRAZOLOPIRIDINE COMPOUNDS AS QUINASE INHIBITORS AR080856A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29864910P 2010-01-27 2010-01-27
US41042610P 2010-11-05 2010-11-05

Publications (1)

Publication Number Publication Date
AR080856A1 true AR080856A1 (en) 2012-05-16

Family

ID=44088992

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100282A AR080856A1 (en) 2010-01-27 2011-01-27 USEFUL PIRAZOLOPIRIDINE COMPOUNDS AS QUINASE INHIBITORS

Country Status (9)

Country Link
US (1) US9067932B2 (en)
EP (1) EP2528917B1 (en)
JP (1) JP5769733B2 (en)
CN (1) CN102858769A (en)
AR (1) AR080856A1 (en)
AU (1) AU2011209726A1 (en)
CA (1) CA2787315A1 (en)
MX (1) MX2012008644A (en)
WO (1) WO2011094273A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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ES2851724T3 (en) * 2013-09-18 2021-09-08 Epiaxis Therapeutics Pty Ltd Stem cell modulation
WO2016029262A1 (en) * 2014-08-25 2016-03-03 University Of Canberra Compositions for modulating cancer stem cells and uses therefor
JP2021502405A (en) * 2017-11-08 2021-01-28 エピアクシス セラピューティクス プロプライエタリー リミテッド Immunogenic compositions and their use

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EP2528916A1 (en) * 2010-01-27 2012-12-05 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors

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US9067932B2 (en) 2015-06-30
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CA2787315A1 (en) 2011-08-04
EP2528917B1 (en) 2016-10-19
CN102858769A (en) 2013-01-02
JP5769733B2 (en) 2015-08-26
US20120071494A1 (en) 2012-03-22
AU2011209726A1 (en) 2012-08-09
MX2012008644A (en) 2012-11-23
EP2528917A1 (en) 2012-12-05

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