AR080426A1 - Composiciones y metodos para preparar polisacraidos de aloe - Google Patents
Composiciones y metodos para preparar polisacraidos de aloeInfo
- Publication number
- AR080426A1 AR080426A1 ARP110100086A ARP110100086A AR080426A1 AR 080426 A1 AR080426 A1 AR 080426A1 AR P110100086 A ARP110100086 A AR P110100086A AR P110100086 A ARP110100086 A AR P110100086A AR 080426 A1 AR080426 A1 AR 080426A1
- Authority
- AR
- Argentina
- Prior art keywords
- aloe
- mixture
- powder
- lyophilized
- cancer
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
- C08B37/0093—Locust bean gum, i.e. carob bean gum, with (beta-1,4)-D-mannose units in the main chain branched with D-galactose units in (alpha-1,6), e.g. from the seeds of carob tree or Ceratonia siliqua; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
- C08B37/0096—Guar, guar gum, guar flour, guaran, i.e. (beta-1,4) linked D-mannose units in the main chain branched with D-galactose units in (alpha-1,6), e.g. from Cyamopsis Tetragonolobus; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Immunology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Sustainable Development (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Oil, Petroleum & Natural Gas (AREA)
Abstract
Un método para preparar un extracto de polimanano a partir de aloe en polvo liofilizado. El extracto de polimanano de la presente solicitud se utiliza también para formular una formulacion inyectable estéril para el tratamiento de uno o más tipos de cáncer, leucemias y linfomas, cáncer de prostata, cáncer de mamas, y cáncer de colon, enfermedades inmunes, en particular neoplasmas relacionados con el sistema inmune, síndrome de deficiencia inmune adquirida, y hepatitis C. Reivindicacion 1: Un método para preparar un polvo fino de un extracto de polimanano que comprende los pasos de: pesar una cantidad específica de un polvo de Aloe liofilizado, donde la cantidad se corrige por su contenido de humedad; disolver el polvo de Aloe liofilizado en agua desionizada para formar una solucion; agregar un solvente orgánico a la solucion para formar una primera mezcla; donde la proporcion entre solvente orgánico y agua desionizada es de por lo menos 2,5:1; permitir que la primera mezcla se sedimente durante por lo menos 8 horas; extraer un volumen específico de un sobrenadante de la primera mezcla y agregar un volumen en exceso de la solucion sobrenadante para formar una segunda mezcla; centrifugar la segunda mezcla; observar la presencia de un precipitado en la segunda mezcla; agregar una cantidad adicional del solvente orgánico a la primera mezcla si se observa la presencia de cualquier precipitado en la segunda mezcla; decantar el sobrenadante de la primera mezcla sifoneándolo, donde la decantacion se realiza solo si no se observa precipitado en la segunda mezcla; filtrar el precipitado de la primera mezcla usando un papel de filtro y un embudo con succion al vacío; recuperar el polvo del extracto de polimanano del embudo con succion raspándolo; dejar el polvo del extracto de polimanano en un matraz de liofilizacion tapado en un congelador durante por lo menos 8 horas; liofilizar el polvo del extracto de polimanano congelado en una liofilizadora; y moler el polvo del extracto de polimanano liofilizado en un molinillo hasta una textura muy fina. Reivindicacion 3: El método de la reivindicacion 1, donde el polvo de Aloe liofilizado se obtiene a partir de una especie de Aloe que se selecciona entre el grupo que consiste en: Aloe Vera, Aloe arborescens, Aloe aristata, Aloe dichotoma, Aloe nyeriensis, Aloe variegate, Aloe barbadensis, y Aloe wildii. Reivindicacion 5: El método de la reivindicacion 1, donde el polvo de Aloe liofilizado comprende polisacáridos de Aloe, donde los polisacáridos de Aloe comprenden uno o más polisacáridos de cadena corta, cadena media, cadena larga, o cadena muy larga, o cualquier combinacion de los mismos. Reivindicacion 6: El método de la reivindicacion 5, donde los polisacáridos de Aloe también comprenden azucares simples, que se seleccionan entre el grupo que consiste en: glucosa, manosa, arabinosa, y galactosa. Reivindicacion 7: El método de la reivindicacion 5, donde los polisacáridos de Aloe tienen un peso molecular dentro del rango entre 11.500 Daltons y más de 10.000.000 Daltons. Reivindicacion 12: El método de la reivindicacion 1, donde el polvo de Aloe liofilizado comprende por lo menos 3,5% de polisacáridos de Aloe con un peso molecular de 1.000.000 Daltons. Reivindicacion 13: El método de la reivindicacion 1, donde el polvo de Aloe liofilizado comprende por lo menos 2,4% de polisacáridos de Aloe con un peso molecular de 2.000.000 Daltons. Reivindicacion 17: La composicion de la reivindicacion 1, donde el polvo de Aloe liofilizado puede contener una o más especies residuales de bajo peso molecular, que se seleccionan entre el grupo que consiste en: glucosa, ácidos orgánicos, ácido láctico, ácidos málicos, ácidos cítricos, y ácido aspártico. Reivindicacion 20: El método de la reivindicacion 19, donde la composicion farmacéutica se utiliza en el tratamiento de una o más malignidades que se seleccionan entre el grupo que consiste en: leucemias y linfomas, cáncer de prostata, cáncer de mamas, y cáncer de colon, y para el tratamiento de uno o más trastornos del sistema inmune. Reivindicacion 23: La composicion de la reivindicacion 21, donde los uno o más conservantes farmacéuticos se seleccionan entre el grupo que consiste en: parabenos, ácido benzoico y sus sales, sustancias mercuriales, sales de amonio cuaternario, alcohol bencílico y otros alcoholes relacionados, y fenoles. Reivindicacion 34: La composicion de la reivindicacion 21, caracterizada porque la composicion se utiliza en el tratamiento de uno o más tipos de cáncer que se seleccionan entre el grupo que consiste en: leucemias y linfomas, cáncer de prostata, cáncer de mamas, y cáncer de colon.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29497010P | 2010-01-14 | 2010-01-14 |
Publications (1)
Publication Number | Publication Date |
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AR080426A1 true AR080426A1 (es) | 2012-04-11 |
Family
ID=44258987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110100086A AR080426A1 (es) | 2010-01-14 | 2011-01-11 | Composiciones y metodos para preparar polisacraidos de aloe |
Country Status (3)
Country | Link |
---|---|
US (4) | US8604187B2 (es) |
AR (1) | AR080426A1 (es) |
TW (1) | TWI488631B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8604187B2 (en) | 2010-01-14 | 2013-12-10 | North Texas Medical Associates | Compositions and methods of aloe polysaccharides |
SG186999A1 (en) * | 2010-07-23 | 2013-02-28 | North Texas Medical Ass | Anti-viral properties of aloe vera and acquired immune deficiency syndrome (aids) treatment |
FI126211B (en) * | 2012-11-09 | 2016-08-15 | Montisera Ltd | Wood-derived hemicelluloses for use in the treatment of lower urinary tract symptoms and disorders |
US10449143B2 (en) | 2014-04-17 | 2019-10-22 | Conopco, Inc. | Aloe vera extract for personal care compositions |
CN106456524B (zh) | 2014-04-17 | 2019-12-10 | 荷兰联合利华有限公司 | 个人护理组合物 |
JP7303558B2 (ja) * | 2017-10-19 | 2023-07-05 | イェール ユニバーシティー | 薬草の抽出物によるアンドロゲン受容体の阻害、及び該抽出物の組成物 |
WO2022015559A1 (en) * | 2020-07-09 | 2022-01-20 | Unigen, Inc | Aloe based compositions comprising polysaccharides and polyphenols for regulation of homeostasis of immunity |
CN114149512B (zh) * | 2020-09-08 | 2023-11-14 | 戴垄生技股份有限公司 | 芦荟萃取物及其制备方法 |
CN116474106A (zh) * | 2023-04-23 | 2023-07-25 | 北京荣祥再生医学研究所有限公司 | 一种药物载体组合物及其在制备药物中的应用、降糖药物 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5308838A (en) * | 1982-05-07 | 1994-05-03 | Carrington Laboratories, Inc. | Uses of aloe products |
US5118673A (en) * | 1982-05-07 | 1992-06-02 | Carrington Laboratories, Inc. | Uses of aloe products |
US5106616A (en) * | 1988-01-14 | 1992-04-21 | Carrington Laboratories, Inc. | Administration of acemannan |
US4735935A (en) * | 1985-12-17 | 1988-04-05 | Carrington Laboratories, Inc. | Process for preparation of aloe products products, produced thereby and compositions thereof |
US4851224A (en) * | 1986-06-05 | 1989-07-25 | Carrington Laboratories, Inc. | Process for preparation of aloe products |
US5902796A (en) * | 1995-09-22 | 1999-05-11 | Carrington Laboratories, Inc. | Bioactive factors of aloe vera plants |
US20030096378A1 (en) * | 1997-10-10 | 2003-05-22 | Univera Pharmaceuticals, Inc. | Process for the preparation of immunomodulatory polysaccharides from aloe |
EP1036187A4 (en) | 1997-10-10 | 2002-03-27 | Univera Pharm Inc | METHOD FOR PRODUCING IMMUNOMODULATING POLYSACCHARIDES FROM ALOL |
US6083508A (en) * | 1998-05-19 | 2000-07-04 | Avalos; Ramiro Estrada | Method of processing aloe leaves |
WO2000041541A2 (en) | 1999-01-12 | 2000-07-20 | Vito-Mannan Polysaccharide L.L.C. | Method of isolating mucilaginous polysaccharides and uses thereof |
AU2002218748A1 (en) * | 2000-07-10 | 2002-01-21 | The University Of Mississippi | High molecular weight polysaccharide fraction from aloe vera with immunostimulatory activity |
CN1362105A (zh) | 2001-01-04 | 2002-08-07 | 杨孟君 | 纳米当归龙荟制剂药物及其制备方法 |
ATE532524T1 (de) * | 2001-03-27 | 2011-11-15 | Pro Pharmaceuticals Inc | Gleichzeitige verabreichung eines polysaccharids mit einem chemotherapeutischen mittel zur behandlung von krebs |
EP1753306B1 (en) | 2004-05-21 | 2013-04-17 | Shunichi Yagi | Aloe powder, aloe juice, and method for producing the same |
US20060084629A1 (en) * | 2004-10-15 | 2006-04-20 | Alvin Needleman | Immune system activating formula composed of selected long chain polysaccharides from natural sources |
WO2008140820A2 (en) * | 2007-05-11 | 2008-11-20 | Aloebiotics Research Labs, Inc. | Aloe preparation for skin enhancement |
CN101070354B (zh) | 2007-05-18 | 2010-04-07 | 中南大学 | 一种利用芦荟同时生产芦荟多糖粉、芦荟活性水的方法 |
CN101306012A (zh) | 2008-06-19 | 2008-11-19 | 中国人民解放军第四军医大学 | 富含甘露糖的改性多糖在制备阻止结肠炎癌变的药物中的应用 |
US8604187B2 (en) | 2010-01-14 | 2013-12-10 | North Texas Medical Associates | Compositions and methods of aloe polysaccharides |
ES2742220T3 (es) | 2011-01-06 | 2020-02-13 | Bespoke Bioscience Llc | Composiciones y procedimientos de polisacáridos de áloe |
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2011
- 2011-01-06 US US12/985,943 patent/US8604187B2/en active Active
- 2011-01-11 AR ARP110100086A patent/AR080426A1/es active IP Right Grant
- 2011-01-14 TW TW100101562A patent/TWI488631B/zh active
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2013
- 2013-11-04 US US14/070,640 patent/US9649326B2/en active Active
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2017
- 2017-04-07 US US15/482,428 patent/US10314858B2/en active Active
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2019
- 2019-05-03 US US16/402,651 patent/US10918659B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10314858B2 (en) | 2019-06-11 |
US20140057867A1 (en) | 2014-02-27 |
US8604187B2 (en) | 2013-12-10 |
US20170246199A1 (en) | 2017-08-31 |
TWI488631B (zh) | 2015-06-21 |
US9649326B2 (en) | 2017-05-16 |
US10918659B2 (en) | 2021-02-16 |
US20190255095A1 (en) | 2019-08-22 |
US20110172181A1 (en) | 2011-07-14 |
TW201143776A (en) | 2011-12-16 |
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