AR079429A1 - CAPSULES OF PHARMACEUTICAL AND ESTERS ACTIVE PRINCIPLES OF POLYINSATURATED FATTY ACIDS - Google Patents
CAPSULES OF PHARMACEUTICAL AND ESTERS ACTIVE PRINCIPLES OF POLYINSATURATED FATTY ACIDSInfo
- Publication number
- AR079429A1 AR079429A1 ARP100104271A ARP100104271A AR079429A1 AR 079429 A1 AR079429 A1 AR 079429A1 AR P100104271 A ARP100104271 A AR P100104271A AR P100104271 A ARP100104271 A AR P100104271A AR 079429 A1 AR079429 A1 AR 079429A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical
- capsule according
- pharmaceutical capsule
- fatty acids
- microcapsules
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Dispersion Chemistry (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composicion farmacéutica en forma de cápsula que contiene ésteres alquílicos de ácidos grasos poliinsaturados (PUFA) y principios activos farmacéuticos para el tratamiento y/o prevencion de enfermedades cardiovasculares y/o procesos inflamatorios. Reivindicacion 1: Cápsula farmacéutica que comprende una suspension de microcápsulas poliméricas que comprenden al menos un polímero y al menos un principio activo farmacéutico seleccionado del grupo formado por antagonistas de los canales de calcio, betabloqueantes, antiagregantes plaquetarios, anticoagulantes y antiinflamatorios no esteroideos, estando dichas microcápsulas suspendidas en un aceite que contiene ésteres alquílicos de ácidos grasos poliinsaturados. Reivindicacion 2: Cápsula farmacéutica segun la reivindicacion 1, donde los ácidos grasos poliinsaturados de dichos ésteres alquílicos pertenecen a la serie omega-3. Reivindicacion 3: Cápsula farmacéutica segun la reivindicacion 2, donde los ácidos grasos poliinsaturados de dichos ésteres alquílicos se seleccionan del grupo formado por ácido eicosapentaenoico, ácido docosahexaenoico, y/o sus mezclas. Reivindicacion 12: Cápsula farmacéutica segun la reivindicacion 1, donde el polímero de dichas microcápsulas se selecciona del grupo formado por proteínas, poliésteres, poliacrilatos, policianoacrilatos, polisacáridos, polietilenglicol y/o sus mezclas. Reivindicacion 14: Cápsula farmacéutica segun la reivindicacion 1, donde dichas microcápsulas representan entre el 0,001% y el 80% del peso total de la cápsula. Reivindicacion 17: Cápsula farmacéutica segun la reivindicacion 1, donde la composicion de la cubierta de dicha cápsula se selecciona del grupo formado por gelatina, hidroxipropilmetilcelulosa, pululano, almidones modificados, carragenanos y/o sus mezclas. Reivindicacion 19: Cápsula farmacéutica segun la reivindicacion 1, donde dicha cápsula tiene un recubrimiento entérico. Reivindicacion 20: Cápsula farmacéutica segun la reivindicacion 1, para el tratamiento y/o prevencion de enfermedades cardiovasculares. Reivindicacion 21: Cápsula farmacéutica segun la reivindicacion 1, para el tratamiento de enfermedades y/o procesos que cursan con inflamacion y/o dolor.Pharmaceutical capsule composition containing alkyl esters of polyunsaturated fatty acids (PUFA) and pharmaceutical active ingredients for the treatment and / or prevention of cardiovascular diseases and / or inflammatory processes. Claim 1: Pharmaceutical capsule comprising a suspension of polymer microcapsules comprising at least one polymer and at least one pharmaceutical active ingredient selected from the group consisting of calcium channel blockers, beta blockers, platelet antiaggregants, anticoagulants and non-steroidal anti-inflammatory drugs, said said being. microcapsules suspended in an oil containing alkyl esters of polyunsaturated fatty acids. Claim 2: Pharmaceutical capsule according to claim 1, wherein the polyunsaturated fatty acids of said alkyl esters belong to the omega-3 series. Claim 3: Pharmaceutical capsule according to claim 2, wherein the polyunsaturated fatty acids of said alkyl esters are selected from the group consisting of eicosapentaenoic acid, docosahexaenoic acid, and / or mixtures thereof. Claim 12: Pharmaceutical capsule according to claim 1, wherein the polymer of said microcapsules is selected from the group consisting of proteins, polyesters, polyacrylates, polycyanoacrylates, polysaccharides, polyethylene glycol and / or mixtures thereof. Claim 14: Pharmaceutical capsule according to claim 1, wherein said microcapsules represent between 0.001% and 80% of the total weight of the capsule. Claim 17: Pharmaceutical capsule according to claim 1, wherein the composition of the cover of said capsule is selected from the group consisting of gelatin, hydroxypropyl methylcellulose, pululane, modified starches, carrageenans and / or mixtures thereof. Claim 19: Pharmaceutical capsule according to claim 1, wherein said capsule has an enteric coating. Claim 20: Pharmaceutical capsule according to claim 1, for the treatment and / or prevention of cardiovascular diseases. Claim 21: Pharmaceutical capsule according to claim 1, for the treatment of diseases and / or processes that occur with inflammation and / or pain.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200931026A ES2363964B1 (en) | 2009-11-20 | 2009-11-20 | CAPSULES OF PHARMACEUTICAL ACTIVE PRINCIPLES AND ESTERS OF POLYINSATURATED FATTY ACIDS. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR079429A1 true AR079429A1 (en) | 2012-01-25 |
Family
ID=43498493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100104271A AR079429A1 (en) | 2009-11-20 | 2010-11-18 | CAPSULES OF PHARMACEUTICAL AND ESTERS ACTIVE PRINCIPLES OF POLYINSATURATED FATTY ACIDS |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR079429A1 (en) |
ES (1) | ES2363964B1 (en) |
TW (1) | TW201141470A (en) |
WO (1) | WO2011060944A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2385240B1 (en) * | 2010-07-26 | 2013-09-23 | Gp-Pharm, S.A. | CAPSULES OF ACTIVE PHARMACEUTICAL PRINCIPLES AND POLYINSATURATED FATTY ACIDS FOR THE TREATMENT OF PROSTATE DISEASES. |
ITMI20112221A1 (en) | 2011-12-05 | 2013-06-06 | Altergon Sa | STABLE FORMULATIONS IN JELLY CAPSULES SPRINGS OF PIASTRINICAL ANTI-AGGREGATES, OMEGA-3 FATTY ACIDS AND AMYLOSUS |
EP2836206A4 (en) * | 2012-04-10 | 2015-11-04 | Rubicon Res Private Ltd | Controlled release pharmaceutical formulations of direct thrombin inhibitors |
WO2014007779A1 (en) * | 2012-07-06 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally-disintegrating formulations of dexketoprofen |
WO2014007780A1 (en) * | 2012-07-06 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally-disintegrating formulations of dexketoprofen |
CN103626689B (en) * | 2012-08-24 | 2016-03-09 | 上海医药工业研究院 | A kind of preparation method of intermediate of Eliquis |
US20150366813A1 (en) * | 2014-06-20 | 2015-12-24 | Banner Life Sciences Llc | Liquid-filled immediate release soft gelatin capsules |
CN106620707B (en) * | 2017-03-14 | 2019-06-07 | 牡丹江医学院 | A kind of pharmaceutical composition and its preparation method and application preventing and treating myocardial ischemia |
CN114869857B (en) * | 2022-05-12 | 2023-04-04 | 郑州大学第一附属医院 | Argatroban particles, preparation and preparation method thereof |
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KR20080055356A (en) | 2006-12-15 | 2008-06-19 | 에스케이케미칼주식회사 | Inclusion complex of clopidogrel and beta-cyclodextrin |
WO2008088808A1 (en) | 2007-01-16 | 2008-07-24 | Reliant Pharmaceuticals, Inc. | Treatment with non-steroidal anti-inflammatory drugs and omega-3 fatty acids, and a combination product thereof |
CA2683611A1 (en) | 2007-04-09 | 2008-10-16 | Usv Limited | Novel stable pharmaceutical compositions of clopidogrel bisulfate and process of preparation thereof |
WO2008132712A2 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Combination pharmaceutical compositions |
-
2009
- 2009-11-20 ES ES200931026A patent/ES2363964B1/en not_active Expired - Fee Related
-
2010
- 2010-11-18 AR ARP100104271A patent/AR079429A1/en unknown
- 2010-11-19 WO PCT/EP2010/007024 patent/WO2011060944A2/en active Application Filing
- 2010-11-19 TW TW099139977A patent/TW201141470A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2011060944A8 (en) | 2011-10-27 |
ES2363964B1 (en) | 2012-08-22 |
ES2363964A1 (en) | 2011-08-22 |
TW201141470A (en) | 2011-12-01 |
WO2011060944A2 (en) | 2011-05-26 |
WO2011060944A3 (en) | 2012-05-03 |
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