AR077823A1 - PROCESS TO PREPARE BENZIMIDAZOL COMPOUNDS REPLACED WITH 2-ARILAMINO OR HETEROARILAMINO - Google Patents
PROCESS TO PREPARE BENZIMIDAZOL COMPOUNDS REPLACED WITH 2-ARILAMINO OR HETEROARILAMINOInfo
- Publication number
- AR077823A1 AR077823A1 ARP100102911A AR077823A1 AR 077823 A1 AR077823 A1 AR 077823A1 AR P100102911 A ARP100102911 A AR P100102911A AR 077823 A1 AR077823 A1 AR 077823A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluorine atoms
- optionally substituted
- alkoxy
- pyridyl
- heteroarilamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos obtenidos son utiles para terapia. Reivindicacion 1: Un proceso para preparar un compuesto de formula (1) en la que: R1, R2, R3 y R4 son cada uno independientemente H, halogeno, hidroxilo, alquilo C1-6 opcionalmente sustituido con hasta tres átomos de fluor, alcoxi C1-6 opcionalmente sustituido con hasta tres átomos de fluor, (alcoxi C1-6)carbonilo, (alcoxi C1-4)carbonilamido, amino o carboxi; y Ar es fenilo, naftilo, 3-piridilo, 4-piridilo o tienilo, en el que el fenilo y el naftilo están opcionalmente sustituidos independientemente con halogeno, alquilo C1-6 opcionalmente sustituido con hasta tres átomos de fluor, o alcoxi C1-6 opcionalmente sustituido con hasta tres átomos de fluor, y en el que el 3-piridilo, el 4-piridilo y el tienilo están opcionalmente sustituidos independientemente con alquilo C1-C6 opcionalmente sustituido con hasta tres átomos de fluor, o alcoxi C1-6 opcionalmente sustituido con hasta tres átomos de fluor; o su sal de adicion de ácidos; que comprende hacer reaccionar un compuesto de formula (2) en la que R1, R2, R3 y R4 son como se definio anteriormente, con un compuesto de formula: Ar-NH2 o su sal de adicion de ácidos, en la que Ar es como se definio anteriormente, opcionalmente en presencia de una base adecuada.The compounds obtained are useful for therapy. Claim 1: A process for preparing a compound of formula (1) in which: R1, R2, R3 and R4 are each independently H, halogen, hydroxyl, C1-6 alkyl optionally substituted with up to three fluorine atoms, C1 alkoxy -6 optionally substituted with up to three fluorine atoms, (C1-6 alkoxy) carbonyl, (C1-4 alkoxy) carbonylamide, amino or carboxy; and Ar is phenyl, naphthyl, 3-pyridyl, 4-pyridyl or thienyl, in which phenyl and naphthyl are optionally independently substituted with halogen, C1-6 alkyl optionally substituted with up to three fluorine atoms, or C1-6 alkoxy optionally substituted with up to three fluorine atoms, and in which 3-pyridyl, 4-pyridyl and thienyl are optionally independently substituted with C1-C6 alkyl optionally substituted with up to three fluorine atoms, or optionally substituted C1-6 alkoxy with up to three fluorine atoms; or its acid addition salt; which comprises reacting a compound of formula (2) in which R1, R2, R3 and R4 are as defined above, with a compound of formula: Ar-NH2 or its acid addition salt, in which Ar is as defined above, optionally in the presence of a suitable base.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23293209P | 2009-08-11 | 2009-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077823A1 true AR077823A1 (en) | 2011-09-28 |
Family
ID=42752011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102911 AR077823A1 (en) | 2009-08-11 | 2010-08-09 | PROCESS TO PREPARE BENZIMIDAZOL COMPOUNDS REPLACED WITH 2-ARILAMINO OR HETEROARILAMINO |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR077823A1 (en) |
| TW (1) | TW201111350A (en) |
| WO (1) | WO2011019781A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6616790B2 (en) * | 2014-06-27 | 2019-12-04 | ノグラ ファーマ リミテッド | Aryl receptor modulators and methods of making and using the same |
| EP3015469B1 (en) | 2014-10-30 | 2018-12-19 | Idemitsu Kosan Co., Ltd. | 5-(benzimidazol-2-yl)benzimidazo[1,2-a]benzimidazoles for electronic applications |
| KR101850282B1 (en) * | 2014-11-26 | 2018-05-31 | 한국과학기술연구원 | Heteroarylamine derivatives as protein kinase inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
| RU2332414C2 (en) * | 2003-12-18 | 2008-08-27 | Тиботек Фармасьютикалз Лтд. | Aminobenzimidazole derivatives as inhibitors of respiratory syncytial virus replication |
-
2010
- 2010-08-09 AR ARP100102911 patent/AR077823A1/en unknown
- 2010-08-10 TW TW99126553A patent/TW201111350A/en unknown
- 2010-08-11 WO PCT/US2010/045110 patent/WO2011019781A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| TW201111350A (en) | 2011-04-01 |
| WO2011019781A1 (en) | 2011-02-17 |
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Legal Events
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|---|---|---|---|
| FB | Suspension of granting procedure |