AR075908A1 - PHARMACEUTICAL FORMULATION CONTAINING IMPROVED ANTIBODY MOLECULES, POLYPEPTIDES. METHOD FOR STABILIZING SOLUTION, ANTIBODY. - Google Patents
PHARMACEUTICAL FORMULATION CONTAINING IMPROVED ANTIBODY MOLECULES, POLYPEPTIDES. METHOD FOR STABILIZING SOLUTION, ANTIBODY.Info
- Publication number
- AR075908A1 AR075908A1 ARP100100904A ARP100100904A AR075908A1 AR 075908 A1 AR075908 A1 AR 075908A1 AR P100100904 A ARP100100904 A AR P100100904A AR P100100904 A ARP100100904 A AR P100100904A AR 075908 A1 AR075908 A1 AR 075908A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- sequence
- cdr1
- cdr2
- cdr3
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Reivindicacion 1: Una formulacion farmacéutica, caracterizada porque comprende al menos un polipéptido seleccionado entre: (a) un polipéptido que comprende una CDR1 que comprende la secuencia de la SEQ ID N°:1 (CDR1 de VH4-M73), una CDR2 que comprende la secuencia de la SEQ ID N°:2 (CDR2 de VH4-M73) y una CDR3 que comprende la secuencia de la SEQ ID N°:3 (CDR3 de VH4-M73); (b) un polipéptido que comprende una CDR1 que comprende la secuencia de la SEQ ID N°:4 (CDR1 de VH3-M73), una CDR2 que comprende la secuencia de la SEQ ID N°:5 (CDR2 de VH3-M73) y una CDR3 que comprende la secuencia de la SEQ ID N°:6 (CDR3 de VH3-M73); (c) un polipéptido que comprende una CDR1 que comprende la secuencia de la SEQ ID N°:7 (CDR1 de VH5-M83), una CDR2 que comprende la secuencia de la SEQ ID N°:8 (CDR2 de VH5-M83) y una CDR3 que comprende la secuencia de la SEQ ID N°:9 (CDR3 de VH5-M83); (d) un polipéptido que comprende una CDR1 que comprende la secuencia de la SEQ ID N°:10 (CDR1 de VL1), una CDR2 que comprende la secuencia de la SEQ ID N°:11 (CDR2 de VL1) y una CDR3 que comprende la secuencia de la SEQ ID N°:12 (CDR3 de VL1); e) un polipéptido que comprende una CDR1 que comprende la secuencia de la SEQ ID N°:13 (CDR1 de VL3), una CDR2 que comprende la secuencia de la SEQ ID N°:14 (CDR2 de VL3) y una CDR3 que comprende la secuencia de la SEQ ID N°:15 (CDR3 de VL3); y (f) un polipéptido que comprende una CDR1 que comprende la secuencia de la SEQ ID N°:16 (CDR1 de VL5), una CDR2 que comprende la secuencia de la SEQ ID N°:17 (CDR2 de VL5) y una CDR3 que comprende la secuencia de la SEQ ID N°:18 (CDR3 de VL5). Reivindicacion 5: Una formulacion farmacéutica estable de acuerdo con cualquiera de las reivindicaciones 1 a 4, caracterizada porque comprende 1-500 mM de agente amortiguador de histidina y/o citrato, 1-1500 mM de al menos un aminoácido cationico, 1-200 mg/mL de anticuerpo, y 1-400 mM de un carbohidrato. Reivindicacion 12: La formulacion de acuerdo con cualquiera de las reivindicaciones 1 a 11, caracterizada porque contiene el polipéptido y/o anticuerpo en una cantidad inferior o igual a 240 mg/ml. Reivindicacion 15: La formulacion de acuerdo con cualquiera de las reivindicaciones 1 a 14, caracterizada porque la formulacion es líquida. Reivindicacion 16: La formulacion de acuerdo con la reivindicacion 15, caracterizada porque no se sometio a liofilizacion durante la preparacion de la misma.Claim 1: A pharmaceutical formulation, characterized in that it comprises at least one polypeptide selected from: (a) a polypeptide comprising a CDR1 comprising the sequence of SEQ ID N °: 1 (CDR1 of VH4-M73), a CDR2 comprising the sequence of SEQ ID N °: 2 (CDR2 of VH4-M73) and a CDR3 comprising the sequence of SEQ ID N °: 3 (CDR3 of VH4-M73); (b) a polypeptide comprising a CDR1 comprising the sequence of SEQ ID N °: 4 (CDR1 of VH3-M73), a CDR2 comprising the sequence of SEQ ID N °: 5 (CDR2 of VH3-M73) and a CDR3 comprising the sequence of SEQ ID N °: 6 (CDR3 of VH3-M73); (c) a polypeptide comprising a CDR1 comprising the sequence of SEQ ID N °: 7 (CDR1 of VH5-M83), a CDR2 comprising the sequence of SEQ ID N °: 8 (CDR2 of VH5-M83) and a CDR3 comprising the sequence of SEQ ID N °: 9 (CDR3 of VH5-M83); (d) a polypeptide comprising a CDR1 comprising the sequence of SEQ ID N °: 10 (CDR1 of VL1), a CDR2 comprising the sequence of SEQ ID N °: 11 (CDR2 of VL1) and a CDR3 which comprises the sequence of SEQ ID N °: 12 (CDR3 of VL1); e) a polypeptide comprising a CDR1 comprising the sequence of SEQ ID N °: 13 (CDR1 of VL3), a CDR2 comprising the sequence of SEQ ID N °: 14 (CDR2 of VL3) and a CDR3 comprising the sequence of SEQ ID N °: 15 (CDR3 of VL3); and (f) a polypeptide comprising a CDR1 comprising the sequence of SEQ ID N °: 16 (CDR1 of VL5), a CDR2 comprising the sequence of SEQ ID N °: 17 (CDR2 of VL5) and a CDR3 comprising the sequence of SEQ ID N °: 18 (CDR3 of VL5). Claim 5: A stable pharmaceutical formulation according to any one of claims 1 to 4, characterized in that it comprises 1-500 mM of histidine and / or citrate buffering agent, 1-1500 mM of at least one cationic amino acid, 1-200 mg / mL of antibody, and 1-400 mM of a carbohydrate. Claim 12: The formulation according to any one of claims 1 to 11, characterized in that it contains the polypeptide and / or antibody in an amount less than or equal to 240 mg / ml. Claim 15: The formulation according to any of claims 1 to 14, characterized in that the formulation is liquid. Claim 16: The formulation according to claim 15, characterized in that it was not subjected to lyophilization during the preparation thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009069095 | 2009-03-19 |
Publications (1)
Publication Number | Publication Date |
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AR075908A1 true AR075908A1 (en) | 2011-05-04 |
Family
ID=42739479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100904A AR075908A1 (en) | 2009-03-19 | 2010-03-19 | PHARMACEUTICAL FORMULATION CONTAINING IMPROVED ANTIBODY MOLECULES, POLYPEPTIDES. METHOD FOR STABILIZING SOLUTION, ANTIBODY. |
Country Status (8)
Country | Link |
---|---|
JP (2) | JP4885308B2 (en) |
KR (1) | KR101468271B1 (en) |
AR (1) | AR075908A1 (en) |
AU (1) | AU2010225951B2 (en) |
RU (1) | RU2565809C2 (en) |
SG (3) | SG10201703707YA (en) |
TW (1) | TWI440470B (en) |
WO (1) | WO2010106812A1 (en) |
Families Citing this family (36)
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WO2007114319A1 (en) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | Method for control of blood kinetics of antibody |
JP5334319B2 (en) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Method for modifying isoelectric point of antibody by amino acid substitution of CDR |
PL2708558T3 (en) | 2008-04-11 | 2018-09-28 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
TWI440469B (en) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
JO3417B1 (en) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-6 receptor (il-6r) antibodies |
AR080428A1 (en) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | FORMULATIONS STABILIZED LIQUID CONTAINERS OF ANTIBODIES |
CN105218674A (en) | 2010-03-11 | 2016-01-06 | 瑞纳神经科学公司 | The antibody combined in pH dependence antigen |
KR20220070586A (en) * | 2010-11-08 | 2022-05-31 | 제넨테크, 인크. | Subcutaneously administered anti-il-6 receptor antibody |
WO2012073992A1 (en) | 2010-11-30 | 2012-06-07 | 中外製薬株式会社 | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
US20140080153A1 (en) * | 2011-01-07 | 2014-03-20 | Chugai Seiyaku Kabushiki Kaisha | Method for improving physical properties of antibody |
WO2012132067A1 (en) * | 2011-03-30 | 2012-10-04 | 中外製薬株式会社 | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
CA2827923C (en) * | 2011-02-25 | 2021-11-23 | Chugai Seiyaku Kabushiki Kaisha | Fc.gamma.riib-specific fc antibody |
UY34105A (en) * | 2011-06-03 | 2012-07-31 | Lg Life Sciences Ltd | STABLE LIQUID FORMULATION OF ETANERCEPT |
EP3939996A1 (en) | 2011-09-30 | 2022-01-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
US9943594B2 (en) | 2011-10-11 | 2018-04-17 | Sanofi Biotechnology | Methods for the treatment of rheumatoid arthritis |
TWI589299B (en) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | Compositions for the treatment of rheumatoid arthritis and methods of using same |
JP6124800B2 (en) | 2011-11-30 | 2017-05-10 | 中外製薬株式会社 | Medicament containing carrier (carrier) into cells forming immune complex |
SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
EP3082861A1 (en) * | 2013-12-20 | 2016-10-26 | DioGenix Inc. | Methods for evaluating neurological disease |
KR102344170B1 (en) | 2013-12-27 | 2021-12-27 | 추가이 세이야쿠 가부시키가이샤 | Method for purifying antibody having low isoelectric point |
US10774148B2 (en) | 2015-02-27 | 2020-09-15 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating IL-6-related diseases |
CA2986210C (en) * | 2015-05-22 | 2022-04-26 | Astellas Pharma Inc. | Novel anti-human ngf antibody fab fragment |
EP3391904A4 (en) | 2015-12-18 | 2019-09-25 | Astellas Pharma Inc. | Pharmaceutical composition containing anti-human tslp receptor antibody |
US10961314B2 (en) * | 2016-09-27 | 2021-03-30 | Fresenius Kabi Deutschland Gmbh | Liquid pharmaceutical composition comprising an anti-IL-6 receptor antibody |
EP3589318A1 (en) * | 2017-03-01 | 2020-01-08 | MedImmune Limited | Formulations of monoclonal antibodies |
JP7185884B2 (en) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | METHOD FOR PREDICTING AND DETERMINING THERAPEUTIC EFFECT OF IL-6 AND NEUTROPHIL-RELATED DISEASE |
KR20200074160A (en) | 2017-10-20 | 2020-06-24 | 가꼬우호우징 효고 이카다이가쿠 | Pharmaceutical composition for inhibiting post-surgical adhesion containing anti-IL-6 receptor antibody |
JP2021504482A (en) * | 2017-11-30 | 2021-02-15 | バイオ−テラ ソリュ−ションズ,エルティーディー. | Liquid formulation of humanized antibody for the treatment of IL-6 related diseases |
TWI822728B (en) | 2018-01-31 | 2023-11-21 | 加藤元一 | Asthma therapeutic agents containing IL-6 inhibitors |
WO2020047029A1 (en) | 2018-08-29 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for treating subjects having rheumatoid arthritis |
MX2021009242A (en) | 2019-01-31 | 2021-10-26 | Sanofi Biotechnology | Anti-il-6 receptor antibody for treating juvenile idiopathic arthritis. |
US20220220210A1 (en) | 2019-03-29 | 2022-07-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function |
JPWO2020213665A1 (en) | 2019-04-17 | 2020-10-22 | ||
CN115697404A (en) | 2020-05-29 | 2023-02-03 | 中外制药株式会社 | Antibody-containing preparation |
KR20220028972A (en) * | 2020-08-31 | 2022-03-08 | (주)셀트리온 | Stable Pharmaceutical Formulation |
KR20230156368A (en) | 2021-03-12 | 2023-11-14 | 추가이 세이야쿠 가부시키가이샤 | Pharmaceutical composition for the treatment or prevention of myasthenia gravis |
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EP1060194A1 (en) * | 1998-02-25 | 2000-12-20 | Lexigen Pharmaceuticals Corp. | Enhancing the circulating half-life of antibody-based fusion proteins |
PT2308888T (en) * | 2001-11-14 | 2017-05-03 | Janssen Biotech Inc | Anti-il-6 antibodies, compositions, methods and uses |
EP1475101B1 (en) * | 2002-02-14 | 2010-10-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution pharmaceuticals |
JP4768439B2 (en) * | 2002-10-15 | 2011-09-07 | アボット バイオセラピューティクス コーポレイション | Modification of antibody FcRn binding affinity or serum half-life by mutagenesis |
AU2004216298B2 (en) * | 2003-02-28 | 2009-04-23 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations |
JP4685764B2 (en) * | 2003-04-10 | 2011-05-18 | アボット バイオセラピューティクス コーポレイション | Modification of antibody FcRn binding affinity or serum half-life by mutagenesis |
JP2008505054A (en) * | 2004-02-11 | 2008-02-21 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | Methods of treating osteoarthritis with IL-6 antagonists |
JO3000B1 (en) * | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
EP1977763A4 (en) * | 2005-12-28 | 2010-06-02 | Chugai Pharmaceutical Co Ltd | Antibody-containing stabilizing preparation |
EP1988922A4 (en) * | 2006-02-03 | 2010-06-02 | Medimmune Llc | Protein formulations |
WO2007114319A1 (en) * | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | Method for control of blood kinetics of antibody |
ATE537190T1 (en) * | 2006-06-02 | 2011-12-15 | Regeneron Pharma | HIGH AFFINE ANTIBODIES AGAINST THE HUMAN IL-6 RECEPTOR |
JP5334319B2 (en) * | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Method for modifying isoelectric point of antibody by amino acid substitution of CDR |
TWI464262B (en) * | 2007-09-26 | 2014-12-11 | 中外製藥股份有限公司 | Antibody constant region mutant |
AU2008304756B8 (en) * | 2007-09-26 | 2015-02-12 | Chugai Seiyaku Kabushiki Kaisha | Anti-IL-6 receptor antibody |
PL2708558T3 (en) * | 2008-04-11 | 2018-09-28 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
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2010
- 2010-03-19 AR ARP100100904A patent/AR075908A1/en unknown
- 2010-03-19 SG SG10201703707YA patent/SG10201703707YA/en unknown
- 2010-03-19 SG SG2011066768A patent/SG174428A1/en unknown
- 2010-03-19 RU RU2011142184/10A patent/RU2565809C2/en active
- 2010-03-19 KR KR1020117024548A patent/KR101468271B1/en active IP Right Grant
- 2010-03-19 WO PCT/JP2010/001977 patent/WO2010106812A1/en active Application Filing
- 2010-03-19 TW TW099108118A patent/TWI440470B/en active
- 2010-03-19 JP JP2010522524A patent/JP4885308B2/en active Active
- 2010-03-19 SG SG10201900451SA patent/SG10201900451SA/en unknown
- 2010-03-19 AU AU2010225951A patent/AU2010225951B2/en active Active
-
2011
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KR20110139745A (en) | 2011-12-29 |
JP2011173918A (en) | 2011-09-08 |
AU2010225951A1 (en) | 2011-09-22 |
TWI440470B (en) | 2014-06-11 |
AU2010225951B2 (en) | 2014-03-13 |
RU2011142184A (en) | 2013-04-27 |
KR101468271B1 (en) | 2014-12-03 |
SG10201900451SA (en) | 2019-02-27 |
RU2565809C2 (en) | 2015-10-20 |
JP4885308B2 (en) | 2012-02-29 |
TW201100100A (en) | 2011-01-01 |
JP2012504106A (en) | 2012-02-16 |
SG10201703707YA (en) | 2017-06-29 |
SG174428A1 (en) | 2011-10-28 |
JP5661553B2 (en) | 2015-01-28 |
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