AR075398A1 - DERIVATIVES OF 3-BENZOFURANIL-INDOL-2-ONA-3-ACETAMIDOPIPERAZINAS REPLACED, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents
DERIVATIVES OF 3-BENZOFURANIL-INDOL-2-ONA-3-ACETAMIDOPIPERAZINAS REPLACED, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICSInfo
- Publication number
- AR075398A1 AR075398A1 ARP100100378A ARP100100378A AR075398A1 AR 075398 A1 AR075398 A1 AR 075398A1 AR P100100378 A ARP100100378 A AR P100100378A AR P100100378 A ARP100100378 A AR P100100378A AR 075398 A1 AR075398 A1 AR 075398A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- alkyl group
- atom
- aryl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- -1 atom halogen Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento de preparacion y la aplicacion terapéutica de dichos compuestos. Reivindicacion 1: Compuesto que responde a la formula (1): en la que: R1 representa un átomo de hidrogeno o un grupo alquilo C1-6, -C(=O)-alquilo C1-6 o -C(=O)-arilo; R2, R3 y R4, idénticos o diferentes, situados en una cualquiera de las posiciones disponibles del nucleo te fenilo, representan independientemente un átomo de hidrogeno, un átomo de halogeno, CN, OH, un grupo alquilo C1-6 eventualmente sustituido con un átomo de halogeno o un OH; perhaloalquilo C1-3, alcoxi C1-6, perhaloalcoxi C1-3, aminocarbonilo, alquil C1-6 aminocarbonilo, di-alquil C1-6-aminocarbonilo, arilo, ariloxi o heteroarilo; pudiendo estar eventualmente sustituidos el grupo arilo, ariloxi o heteroarilo con un átomo de halogeno, CN, OH o un grupo alquilo C1-6, perhaloalquilo C1-3 o alcoxi C1-6; entendiéndose que al menos uno de R2, R3 y R4 es diferente de H y que el grupo arilo, ariloxi o heteroarilo puede estar eventualmente sustituido con un átomo de halogeno, CN, OH o un grupo alquilo C1-6, perhaloalquilo C1-3 o alcoxi C1-6; R5 y R6, idénticos o diferentes, representan un átomo de hidrogeno, un grupo alquilo C1-6 o R5 y R6 forman conjuntamente un ciclo de C3-6 átomos de carbono; R7 representa un grupo alquilo C1-6 o un grupo alquenilo C2-6; R8 y R9, situados sobre una cualquiera de las posiciones disponibles del anillo de piperazina, representan un átomo de hidrogeno, un grupo alquilo C1-6 o un grupo alquenilo C2-6, entendiéndose que al menos uno de entre R8 y R9 es diferente de H; o dos de entre R7, R8 y R9 forman conjuntamente un ciclo de C3-6 átomos de carbono; entendiéndose que R8 y R9 pueden encontrarse en posicion geminal sobre el mismo átomo de carbono; n representa 1 o 2; en forma de base o de sal de adicion de un ácido.Preparation procedure and therapeutic application of said compounds. Claim 1: Compound that responds to formula (1): wherein: R 1 represents a hydrogen atom or a C 1-6 alkyl group, -C (= O) -C 1-6 alkyl or -C (= O) - aryl; R2, R3 and R4, identical or different, located in any of the available positions of the phenyl nucleus, independently represent a hydrogen atom, a halogen atom, CN, OH, a C1-6 alkyl group optionally substituted with an atom halogen or an OH; C1-3 perhaloalkyl, C1-6 alkoxy, C1-3 perhaloalkoxy, aminocarbonyl, C1-6 alkyl aminocarbonyl, di- C1-6 alkyl aminocarbonyl, aryl, aryloxy or heteroaryl; the aryl, aryloxy or heteroaryl group may optionally be substituted with a halogen atom, CN, OH or a C1-6 alkyl, C1-3 perhaloalkyl or C1-6 alkoxy group; it being understood that at least one of R2, R3 and R4 is different from H and that the aryl, aryloxy or heteroaryl group may eventually be substituted with a halogen atom, CN, OH or a C1-6 alkyl group, C1-3 perhaloalkyl or C1-6 alkoxy; R5 and R6, identical or different, represent a hydrogen atom, a C1-6 alkyl group or R5 and R6 together form a cycle of C3-6 carbon atoms; R7 represents a C1-6 alkyl group or a C2-6 alkenyl group; R8 and R9, located on any one of the available positions of the piperazine ring, represent a hydrogen atom, a C1-6 alkyl group or a C2-6 alkenyl group, it being understood that at least one of R8 and R9 is different from H; or two of R7, R8 and R9 together form a cycle of C3-6 carbon atoms; it being understood that R8 and R9 can be in geminal position on the same carbon atom; n represents 1 or 2; in the form of base or salt of addition of an acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0900620A FR2941946B1 (en) | 2009-02-12 | 2009-02-12 | SUBSTITUTED 3-BENZOFURANYL-INDOL-2-ONE-3-ACETAMIDOPIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075398A1 true AR075398A1 (en) | 2011-03-30 |
Family
ID=40756656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100378A AR075398A1 (en) | 2009-02-12 | 2010-02-11 | DERIVATIVES OF 3-BENZOFURANIL-INDOL-2-ONA-3-ACETAMIDOPIPERAZINAS REPLACED, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20110312972A1 (en) |
| EP (1) | EP2396319B1 (en) |
| JP (1) | JP5694958B2 (en) |
| KR (1) | KR20110118157A (en) |
| CN (1) | CN102361864B (en) |
| AR (1) | AR075398A1 (en) |
| AU (1) | AU2010212704B2 (en) |
| BR (1) | BRPI1008562A2 (en) |
| CA (1) | CA2752198C (en) |
| FR (1) | FR2941946B1 (en) |
| HK (1) | HK1164861A1 (en) |
| IL (1) | IL214544A0 (en) |
| JO (1) | JO2851B1 (en) |
| MX (1) | MX2011008546A (en) |
| MY (1) | MY152069A (en) |
| RU (1) | RU2542980C2 (en) |
| SG (1) | SG173623A1 (en) |
| TW (1) | TWI461421B (en) |
| UY (1) | UY32448A (en) |
| WO (1) | WO2010092288A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2941946B1 (en) | 2009-02-12 | 2011-03-25 | Sanofi Aventis | SUBSTITUTED 3-BENZOFURANYL-INDOL-2-ONE-3-ACETAMIDOPIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| FR2941947B1 (en) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | 3-BENZOFURANYL-INDOL-2-ONE 3-DERIVED DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| CA2778990A1 (en) | 2009-10-30 | 2011-05-05 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2714378B1 (en) | 1993-12-24 | 1996-03-15 | Sanofi Sa | Indol-2-one derivatives substituted in 3 with a nitrogen group, their preparation, pharmaceutical compositions containing them. |
| CN1161333C (en) * | 1998-08-20 | 2004-08-11 | 住友制药株式会社 | Oxindole derivatives as growth hormone releasers |
| AU772189B2 (en) * | 1999-08-23 | 2004-04-08 | Solvay Pharmaceuticals B.V. | New phenylpiperazines |
| EP1634594A1 (en) * | 2000-06-29 | 2006-03-15 | NeuroSearch A/S | Use of 3-substituted oxindole derivatives as KCNQ potassium channel modulators |
| JPWO2002060878A1 (en) * | 2001-01-30 | 2004-06-03 | 住友製薬株式会社 | Benzimidazolidinone derivatives |
| FR2827604B1 (en) | 2001-07-17 | 2003-09-19 | Sanofi Synthelabo | NOVEL 1-PHENYLSULFONYL-1,3-DIHYDRO-2H-INDOL-2- ONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US20050070718A1 (en) * | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| JPWO2005035498A1 (en) * | 2003-10-08 | 2006-12-21 | 住友製薬株式会社 | Use of nitrogen-containing bicyclic compounds as food intake regulators |
| TWI391387B (en) * | 2004-05-12 | 2013-04-01 | Eisai R&D Man Co Ltd | Indole derivative having piperidine ring |
| TW200745033A (en) * | 2005-09-14 | 2007-12-16 | Dainippon Sumitomo Pharma Co | Oxindole derivative as feeding control agent |
| FR2920023B1 (en) * | 2007-08-16 | 2013-02-08 | Sanofi Aventis | 3-DISUBSTITUTED INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
| FR2941947B1 (en) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | 3-BENZOFURANYL-INDOL-2-ONE 3-DERIVED DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| FR2941946B1 (en) | 2009-02-12 | 2011-03-25 | Sanofi Aventis | SUBSTITUTED 3-BENZOFURANYL-INDOL-2-ONE-3-ACETAMIDOPIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
-
2009
- 2009-02-12 FR FR0900620A patent/FR2941946B1/en not_active Expired - Fee Related
-
2010
- 2010-02-09 SG SG2011057551A patent/SG173623A1/en unknown
- 2010-02-09 MX MX2011008546A patent/MX2011008546A/en active IP Right Grant
- 2010-02-09 WO PCT/FR2010/050206 patent/WO2010092288A1/en active Application Filing
- 2010-02-09 CA CA2752198A patent/CA2752198C/en not_active Expired - Fee Related
- 2010-02-09 AU AU2010212704A patent/AU2010212704B2/en not_active Ceased
- 2010-02-09 BR BRPI1008562A patent/BRPI1008562A2/en not_active Application Discontinuation
- 2010-02-09 JP JP2011549642A patent/JP5694958B2/en not_active Expired - Fee Related
- 2010-02-09 RU RU2011137408/04A patent/RU2542980C2/en not_active IP Right Cessation
- 2010-02-09 CN CN201080012865.XA patent/CN102361864B/en not_active Expired - Fee Related
- 2010-02-09 MY MYPI2011003748 patent/MY152069A/en unknown
- 2010-02-09 EP EP10708306.5A patent/EP2396319B1/en active Active
- 2010-02-09 US US13/201,141 patent/US20110312972A1/en not_active Abandoned
- 2010-02-09 KR KR1020117020970A patent/KR20110118157A/en not_active Application Discontinuation
- 2010-02-10 JO JO201042A patent/JO2851B1/en active
- 2010-02-11 AR ARP100100378A patent/AR075398A1/en unknown
- 2010-02-11 TW TW099104420A patent/TWI461421B/en not_active IP Right Cessation
- 2010-02-12 UY UY0001032448A patent/UY32448A/en not_active Application Discontinuation
-
2011
- 2011-08-09 IL IL214544A patent/IL214544A0/en unknown
-
2012
- 2012-06-07 HK HK12105546.4A patent/HK1164861A1/en not_active IP Right Cessation
-
2016
- 2016-11-10 US US15/348,834 patent/US9889130B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SG173623A1 (en) | 2011-09-29 |
| KR20110118157A (en) | 2011-10-28 |
| CA2752198A1 (en) | 2010-08-19 |
| TW201041877A (en) | 2010-12-01 |
| US9889130B2 (en) | 2018-02-13 |
| EP2396319A1 (en) | 2011-12-21 |
| US20110312972A1 (en) | 2011-12-22 |
| WO2010092288A1 (en) | 2010-08-19 |
| AU2010212704A1 (en) | 2011-09-01 |
| BRPI1008562A2 (en) | 2017-06-06 |
| FR2941946B1 (en) | 2011-03-25 |
| CN102361864B (en) | 2015-11-25 |
| UY32448A (en) | 2010-09-30 |
| CN102361864A (en) | 2012-02-22 |
| CA2752198C (en) | 2017-05-30 |
| AU2010212704B2 (en) | 2015-11-12 |
| JP2012517460A (en) | 2012-08-02 |
| MX2011008546A (en) | 2011-11-18 |
| JP5694958B2 (en) | 2015-04-01 |
| IL214544A0 (en) | 2011-09-27 |
| RU2011137408A (en) | 2013-03-20 |
| MY152069A (en) | 2014-08-15 |
| EP2396319B1 (en) | 2013-07-17 |
| US20170119761A1 (en) | 2017-05-04 |
| HK1164861A1 (en) | 2012-09-28 |
| TWI461421B (en) | 2014-11-21 |
| FR2941946A1 (en) | 2010-08-13 |
| JO2851B1 (en) | 2015-03-15 |
| RU2542980C2 (en) | 2015-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |