AR073755A1 - ORAL FORMULATION THAT INCLUDES 4 - [(1R, 3S) -6-CHLORO-3-FENILINDAN-1-IL] -1,2,2-TRIMETHYLPIPERAZINE. USE. METHOD. - Google Patents

ORAL FORMULATION THAT INCLUDES 4 - [(1R, 3S) -6-CHLORO-3-FENILINDAN-1-IL] -1,2,2-TRIMETHYLPIPERAZINE. USE. METHOD.

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Publication number
AR073755A1
AR073755A1 ARP090103813A ARP090103813A AR073755A1 AR 073755 A1 AR073755 A1 AR 073755A1 AR P090103813 A ARP090103813 A AR P090103813A AR P090103813 A ARP090103813 A AR P090103813A AR 073755 A1 AR073755 A1 AR 073755A1
Authority
AR
Argentina
Prior art keywords
disorder
composition
compound
trimethylpiperazine
chloro
Prior art date
Application number
ARP090103813A
Other languages
Spanish (es)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41217546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073755(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR073755A1 publication Critical patent/AR073755A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composicion farmacéutica destinada a la administracion oral que comprende bajas dosis de 4-((1R,3S)-6-cloro-3-fenilindan-1-il)-1,2,2-trimetilpiperazina y a una composicion que comprende el compuesto. Reivindicacion 7: La composicion de cualquiera de las reivindicaciones 1-6 para el tratamiento de disfuncion cognitiva, esquizofrenia, trastorno esquizofreniforme, trastorno ezquizoafectivo, trastorno delirante, trastorno psicotico breve, trastorno psicotico compartido, manía en trastorno bipolar, trastornos de ansiedad, depresion, mantenimiento de trastornos bipolares, alteraciones del sueno, migrana, parkinsonismo inducido por neurolépticos, o abuso de cocaína, abuso de nicotina, o abuso de alcohol. Reivindicacion 10: Una composicion farmacéutica que comprende el compuesto de formula (1) y povidona o copovidona como aglutinante. Reivindicacion 13: La composicion de cualquiera de las reivindicaciones 10-12 en donde el compuesto de formula (1) está en la forma de la sal de succinato.Pharmaceutical composition intended for oral administration comprising low doses of 4 - ((1R, 3S) -6-chloro-3-phenylindan-1-yl) -1,2,2-trimethylpiperazine and a composition comprising the compound. Claim 7: The composition of any of claims 1-6 for the treatment of cognitive dysfunction, schizophrenia, schizophreniform disorder, ezquizoafective disorder, delusional disorder, brief psychotic disorder, shared psychotic disorder, mania in bipolar disorder, anxiety disorders, depression, maintenance of bipolar disorders, sleep disorders, migraine, neuroleptic-induced parkinsonism, or cocaine abuse, nicotine abuse, or alcohol abuse. Claim 10: A pharmaceutical composition comprising the compound of formula (1) and povidone or copovidone as a binder. Claim 13: The composition of any one of claims 10-12 wherein the compound of formula (1) is in the form of the succinate salt.

ARP090103813A 2008-10-03 2009-10-02 ORAL FORMULATION THAT INCLUDES 4 - [(1R, 3S) -6-CHLORO-3-FENILINDAN-1-IL] -1,2,2-TRIMETHYLPIPERAZINE. USE. METHOD. AR073755A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200801392 2008-10-03
DKPA200900591 2009-05-07

Publications (1)

Publication Number Publication Date
AR073755A1 true AR073755A1 (en) 2010-12-01

Family

ID=41217546

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103813A AR073755A1 (en) 2008-10-03 2009-10-02 ORAL FORMULATION THAT INCLUDES 4 - [(1R, 3S) -6-CHLORO-3-FENILINDAN-1-IL] -1,2,2-TRIMETHYLPIPERAZINE. USE. METHOD.

Country Status (16)

Country Link
US (1) US20110178094A1 (en)
EP (1) EP2344163A1 (en)
JP (1) JP2012504560A (en)
KR (1) KR20110081176A (en)
CN (1) CN102170884A (en)
AR (1) AR073755A1 (en)
AU (1) AU2009298264A1 (en)
BR (1) BRPI0919165A2 (en)
CA (1) CA2732613A1 (en)
CO (1) CO6321158A2 (en)
EA (1) EA201170512A1 (en)
IL (1) IL210235A0 (en)
MX (1) MX2011001044A (en)
NZ (1) NZ590897A (en)
WO (1) WO2010037398A1 (en)
ZA (1) ZA201102446B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004000260T2 (en) 2003-07-22 2006-08-24 Arena Pharmaceuticals, Inc., San Diego DIARYL AND ARYLHETEROARYL DRUG DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR SUITABLE FOR THE PROPHYLAXIS AND TREATMENT OF RELATED DISEASES THEREOF
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
KR20110021754A (en) * 2008-05-07 2011-03-04 하. 룬드벡 아크티에셀스카브 Method for treating cognitive deficits
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
SI2720989T1 (en) 2011-06-20 2016-11-30 H. Lundbeck A/S Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia
JO3421B1 (en) 2011-06-20 2019-10-20 H Lundbeck As Method of administration of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia
MX2017016413A (en) 2015-06-12 2018-08-01 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder.
JP2018520187A (en) 2015-07-15 2018-07-26 アクソヴァント サイエンシーズ ゲゼルシャフト ミット ベシュレンクテル ハフツングAxovant Sciences GmbH Diaryl and arylheteroaryl urea derivatives as modulators of 5-HT2A serotonin receptors useful for the prevention and treatment of hallucinations associated with neurodegenerative diseases
US20210395208A1 (en) 2018-10-29 2021-12-23 H. Lundeck A/S Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts
CN113056457A (en) 2018-12-03 2021-06-29 H.隆德贝克有限公司 4- ((1R,3S) -6-chloro-3-phenyl-2, 3-dihydro-1H-inden-1-yl) -1,2, 2-trimethylpiperazine and 4- ((1R,3S) -6-chloro-3- (phenyl-d)5) -2, 3-dihydro-1H-inden-1-yl) -2, 2-dimethyl-1- (methyl-d3) Prodrugs of piperazine

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IE50867B1 (en) * 1980-02-29 1986-08-06 Kefalas As Indane derivatives
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Also Published As

Publication number Publication date
EP2344163A1 (en) 2011-07-20
CA2732613A1 (en) 2010-04-08
ZA201102446B (en) 2012-07-25
JP2012504560A (en) 2012-02-23
CN102170884A (en) 2011-08-31
KR20110081176A (en) 2011-07-13
WO2010037398A1 (en) 2010-04-08
CO6321158A2 (en) 2011-09-20
EA201170512A1 (en) 2011-08-30
IL210235A0 (en) 2011-03-31
NZ590897A (en) 2012-07-27
BRPI0919165A2 (en) 2015-12-08
AU2009298264A1 (en) 2010-04-08
US20110178094A1 (en) 2011-07-21
MX2011001044A (en) 2011-03-21

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