AR071954A1 - DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM. - Google Patents

DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM.

Info

Publication number
AR071954A1
AR071954A1 ARP090101936A ARP090101936A AR071954A1 AR 071954 A1 AR071954 A1 AR 071954A1 AR P090101936 A ARP090101936 A AR P090101936A AR P090101936 A ARP090101936 A AR P090101936A AR 071954 A1 AR071954 A1 AR 071954A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
oxo
optionally substituted
fluoro
Prior art date
Application number
ARP090101936A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR071954A1 publication Critical patent/AR071954A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se reivindican compuestos de formula (1), en la que R1 es hidrogeno, alquilo C1-3, alcoxi C1-3, ciano, hidroxi o halo; y en el que dicho alquilo C1-3 est  opcionalmente sustituido con uno o m s sustituyentes seleccionados independientemente de hidroxi, alcoxi C1-3 y fluoro; y dicho alcoxi C1-3 est  opcionalmente sustituido con uno o m s fluoro; m es 1 o 2; R2 y R3 se seleccionan cada uno independientemente de hidrogeno, haloalquilo C1-4, haloalcoxi C1-4, halo, alcoxi C1-4, alquilo C1-4 y cicloalquil C3-7-oxi; en los que dicho cicloalquil C3-7-oxi est  opcionalmente sustituido con uno o m s fluoro; y R2 y R3 no pueden ser ambos hidrogeno; D es cicloalquilo C3-7 o heterocicloalquilo C3-7; y en el que dichos cicloalquilo C3-7 o heterocicloalquilo C3-7 pueden estar opcionalmente sustituidos con uno o m s X4; X4 es halo, alquilo C1-3, alquil C1-3-O-alquilo C1-3, alcoxi C1-3, bencilo, alquil C1-4-sulfonilo, oxo, R4O(C=O), R5(C=O), o heteroarilo C5-6; en el que dichos alquilo C1-3, alquil C1-3-O-alquilo C1-3, alcoxi C1-3 y alquil C1-4-sulfonilo est n opcionalmente sustituidos con uno o m s fluoro; R4 es alquilo C1-4, alquil C1-4-O-alquilo C1-4, cicloalquilo C5-6, o arilo; R5 es alquilo C1-4, fluoroalquilo C1-4 o heteroarilo C5-6; L1 es alquileno C1-4 o un enlace; L2 es alquileno C1-3; con la excepcion del compuesto 2-(ciclohexilmetil )-3-oxo-N-[2-(trifluorometil)bencil]isoindolin-1-carboxamida; as¡ como una sal farmaceuticamente aceptable, o un isomero de los mismos, o una sal de dicho isomero. Los compuestos de la invencion son utiles en terapia, tal como terapia contra el dolor.Compounds of formula (1) are claimed, wherein R 1 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, cyano, hydroxy or halo; and wherein said C1-3 alkyl is optionally substituted with one or more substituents independently selected from hydroxy, C1-3 alkoxy and fluoro; and said C1-3 alkoxy is optionally substituted with one or more fluoro; m is 1 or 2; R 2 and R 3 are each independently selected from hydrogen, C 1-4 haloalkyl, C 1-4 haloalkoxy, halo, C 1-4 alkoxy, C 1-4 alkyl and C 3-7 cycloalkyl; wherein said C3-7-oxycycloalkyl is optionally substituted with one or more fluoro; and R2 and R3 cannot both be hydrogen; D is C3-7 cycloalkyl or C3-7 heterocycloalkyl; and wherein said C3-7 cycloalkyl or C3-7 heterocycloalkyl may be optionally substituted with one or more X4; X4 is halo, C1-3 alkyl, C1-3 alkyl-O-C1-3 alkyl, C1-3 alkoxy, benzyl, C1-4 alkyl sulfonyl, oxo, R4O (C = O), R5 (C = O) , or C5-6 heteroaryl; wherein said C1-3 alkyl, C1-3 alkyl-O-C1-3 alkyl, C1-3 alkoxy and C1-4 alkyl sulfonyl are optionally substituted with one or more fluoro; R4 is C1-4 alkyl, C1-4 alkyl-O-C1-4 alkyl, C5-6 cycloalkyl, or aryl; R5 is C1-4 alkyl, C1-4 fluoroalkyl or C5-6 heteroaryl; L1 is C1-4 alkylene or a bond; L2 is C1-3 alkylene; with the exception of the compound 2- (cyclohexylmethyl) -3-oxo-N- [2- (trifluoromethyl) benzyl] isoindolin-1-carboxamide; as well as a pharmaceutically acceptable salt, or an isomer thereof, or a salt of said isomer. The compounds of the invention are useful in therapy, such as pain therapy.

ARP090101936A 2008-05-30 2009-05-29 DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM. AR071954A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5731008P 2008-05-30 2008-05-30

Publications (1)

Publication Number Publication Date
AR071954A1 true AR071954A1 (en) 2010-07-28

Family

ID=41377346

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090101936A AR071954A1 (en) 2008-05-30 2009-05-29 DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM.

Country Status (6)

Country Link
AR (1) AR071954A1 (en)
CL (1) CL2009001328A1 (en)
PE (1) PE20100052A1 (en)
TW (1) TW201000446A (en)
UY (1) UY31854A (en)
WO (1) WO2009145721A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278302B2 (en) * 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
UA109290C2 (en) 2010-10-07 2015-08-10 Common Crystals and Salts of CCR3 Inhibitors
CN106478497B (en) 2010-10-18 2020-05-08 拉夸里亚创药株式会社 Arylamine derivatives as TTX-S blockers
AR090566A1 (en) 2012-04-02 2014-11-19 Boehringer Ingelheim Int PROCESS FOR THE PRODUCTION OF CRR INHIBITORS
US10213421B2 (en) 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
WO2018110669A1 (en) 2016-12-15 2018-06-21 Ono Pharmaceutical Co., Ltd. Activator of trek (twik related k+ channels) channels
BR112021001608A2 (en) 2018-09-10 2021-04-27 Kaken Pharmaceutical Co., Ltd. innovative heteroaromatic amide derivative and medicine containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
GB0514017D0 (en) * 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
US20090291983A1 (en) * 2006-07-12 2009-11-26 Astrazeneca Ab 3-Oxoisoindoline-1-Carboxamide Derivatives as Analgesic Agents
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
GB0705882D0 (en) * 2007-03-27 2007-05-02 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
UY31854A (en) 2010-01-05
PE20100052A1 (en) 2010-02-20
CL2009001328A1 (en) 2010-01-15
TW201000446A (en) 2010-01-01
WO2009145721A1 (en) 2009-12-03

Similar Documents

Publication Publication Date Title
AR071954A1 (en) DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM.
AR072952A1 (en) 2-IMINO-3-METHYL-PIRROLOPIRIMIDINONA PHENYL-REPLACED COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS AND THEIR USE
ECSP067013A (en) 2-QUINOLIL-OXAZOLES REPLACED USEFUL AS PDE INHIBITORS4
AR051995A1 (en) TIENO-PYRIDINE DERIVATIVES AS GABA -B ALLOSTERIC INTENSIFIERS
AR055150A1 (en) ISOINDOL COMPOUNDS - IMIDO AND COMPOSITIONS THAT INCLUDE THEM AND THEIR METHODS OF USE
CR10346A (en) DERIVATIVES OF AZABICICLO [3.1.0] HEXIL AS MODULAR OF DOPAMINE D3 RECEIVERS
CL2012000999A1 (en) Substituted pyrazolospiroketone derivative compounds, acetyl-coa carboxylase inhibitors; pharmaceutical composition comprising them; use to treat or delay the progression or onset of type 2 diabetes, non-alcoholic fatty liver (hgna), or hepatic insulin resistance.
AR079205A1 (en) MORPHOLINOTIAZOLS AS POSITIVE ALOSTERIC MODULATORS ALFA 7
AR067663A1 (en) HETEROCICLIC DERIVATIVES OF ETILOXI AMIDAS, COMPOSITIONS THAT INCLUDE THEM AND USES OF THE SAME IN AGRICULTURE OR HORTICULTURE, AS ANTIFUNGIC AGENTS.
AR050266A1 (en) DERIVATIVES OF BENCIL-TRIAZOLONA AS NON-NUCLEOSID INHIBITORS OF INVERSE TRANSCRIPT
AR062797A1 (en) PIPERIDINE DERIVATIVES AS RENINE INHIBITORS, PHARMACEUTICAL COMPOSITIONS.
AR061243A1 (en) DERIVATIVES OF N-2-FENILETIL-CARBOXAMIDS, COMPOSITIONS FOR THE CONTROL OF PHYTO-PATHOGENIC MOCROORGANISMS THAT INCLUDE THEM AND A METHOD OF CONTROL OR PREVENTION OF USEFUL PLANTS USING THEM.
AR072166A1 (en) PIPERIDINE DERIVATIVE AND ITS USE AS A SUPERIOR RENINA INHIBITOR
AR060489A1 (en) BENZOAZEPIN ACID DERIVATIVES - OXI- ACETIC AS A PPAR - DELTA AGONIST USED TO INCREASE HDL-C, REDUCE LDL-C AND REDUCE CHOLESTEROL
PE20130039A1 (en) PYRAZOLES FUNGICIDES
AR060604A1 (en) NEW ARILAMINO N- HETEROARILOS AS MEK INHIBITORS
AR069480A1 (en) DERIVATIVES OF 2-AMINO-PYRIMIDINE
AR073932A1 (en) ESTERES COMPOUNDS OF ACID 2- (AMINOMETILIDEN) -4,4-DIFLUORO-3- OXOBUTIRICO AND PROCEDURE FOR PREPARATION
CU20080165A7 (en) DERIVATIVES OF 1,2,4,5-TETRAHIDRO-3H-BENZAZEPINAS, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR082004A1 (en) PIRIDINE FUSION COMPOUNDS
AR069814A1 (en) DERIVATIVES OF 4 AMINO-PYRIMIDINE, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR069813A1 (en) DERIVATIVES OF 2- AMINO-PYRIMIDINE, A PHARMACEUTICAL COMPOSITION, A METHOD OF PREPARATION OF THE COMPOUND AND USE OF IT TO PREPARE A MEDICINAL PRODUCT
AR072188A1 (en) CYCLIC SULFONAMIDE COMPOUNDS, PROCEDURE FOR PREPARATION, A COMPOSITION THAT CONTAINS THEM, A PEST CONTROL METHOD THAT USES IT AND ITS USE IN VETERINARY MEDICINE FOR PROTECTION AGAINST PARASITES.
AR074353A1 (en) NAFTALEN-2-IL-ACETIC ACIDS SUBSTITUTED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE OF THE SAME IN THE TREATMENT OF ALLERGIC DISEASES, SUCH AS RHINITIS, ASTHMA AND ATOPIC DERMATITITIS.
AR053141A1 (en) IMIDAZOLS REPLACED WITH HETEROCICLILAMIDE

Legal Events

Date Code Title Description
FB Suspension of granting procedure