AR071954A1 - DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM. - Google Patents
DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM.Info
- Publication number
- AR071954A1 AR071954A1 ARP090101936A ARP090101936A AR071954A1 AR 071954 A1 AR071954 A1 AR 071954A1 AR P090101936 A ARP090101936 A AR P090101936A AR P090101936 A ARP090101936 A AR P090101936A AR 071954 A1 AR071954 A1 AR 071954A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- oxo
- optionally substituted
- fluoro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Se reivindican compuestos de formula (1), en la que R1 es hidrogeno, alquilo C1-3, alcoxi C1-3, ciano, hidroxi o halo; y en el que dicho alquilo C1-3 est opcionalmente sustituido con uno o m s sustituyentes seleccionados independientemente de hidroxi, alcoxi C1-3 y fluoro; y dicho alcoxi C1-3 est opcionalmente sustituido con uno o m s fluoro; m es 1 o 2; R2 y R3 se seleccionan cada uno independientemente de hidrogeno, haloalquilo C1-4, haloalcoxi C1-4, halo, alcoxi C1-4, alquilo C1-4 y cicloalquil C3-7-oxi; en los que dicho cicloalquil C3-7-oxi est opcionalmente sustituido con uno o m s fluoro; y R2 y R3 no pueden ser ambos hidrogeno; D es cicloalquilo C3-7 o heterocicloalquilo C3-7; y en el que dichos cicloalquilo C3-7 o heterocicloalquilo C3-7 pueden estar opcionalmente sustituidos con uno o m s X4; X4 es halo, alquilo C1-3, alquil C1-3-O-alquilo C1-3, alcoxi C1-3, bencilo, alquil C1-4-sulfonilo, oxo, R4O(C=O), R5(C=O), o heteroarilo C5-6; en el que dichos alquilo C1-3, alquil C1-3-O-alquilo C1-3, alcoxi C1-3 y alquil C1-4-sulfonilo est n opcionalmente sustituidos con uno o m s fluoro; R4 es alquilo C1-4, alquil C1-4-O-alquilo C1-4, cicloalquilo C5-6, o arilo; R5 es alquilo C1-4, fluoroalquilo C1-4 o heteroarilo C5-6; L1 es alquileno C1-4 o un enlace; L2 es alquileno C1-3; con la excepcion del compuesto 2-(ciclohexilmetil )-3-oxo-N-[2-(trifluorometil)bencil]isoindolin-1-carboxamida; as¡ como una sal farmaceuticamente aceptable, o un isomero de los mismos, o una sal de dicho isomero. Los compuestos de la invencion son utiles en terapia, tal como terapia contra el dolor.Compounds of formula (1) are claimed, wherein R 1 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, cyano, hydroxy or halo; and wherein said C1-3 alkyl is optionally substituted with one or more substituents independently selected from hydroxy, C1-3 alkoxy and fluoro; and said C1-3 alkoxy is optionally substituted with one or more fluoro; m is 1 or 2; R 2 and R 3 are each independently selected from hydrogen, C 1-4 haloalkyl, C 1-4 haloalkoxy, halo, C 1-4 alkoxy, C 1-4 alkyl and C 3-7 cycloalkyl; wherein said C3-7-oxycycloalkyl is optionally substituted with one or more fluoro; and R2 and R3 cannot both be hydrogen; D is C3-7 cycloalkyl or C3-7 heterocycloalkyl; and wherein said C3-7 cycloalkyl or C3-7 heterocycloalkyl may be optionally substituted with one or more X4; X4 is halo, C1-3 alkyl, C1-3 alkyl-O-C1-3 alkyl, C1-3 alkoxy, benzyl, C1-4 alkyl sulfonyl, oxo, R4O (C = O), R5 (C = O) , or C5-6 heteroaryl; wherein said C1-3 alkyl, C1-3 alkyl-O-C1-3 alkyl, C1-3 alkoxy and C1-4 alkyl sulfonyl are optionally substituted with one or more fluoro; R4 is C1-4 alkyl, C1-4 alkyl-O-C1-4 alkyl, C5-6 cycloalkyl, or aryl; R5 is C1-4 alkyl, C1-4 fluoroalkyl or C5-6 heteroaryl; L1 is C1-4 alkylene or a bond; L2 is C1-3 alkylene; with the exception of the compound 2- (cyclohexylmethyl) -3-oxo-N- [2- (trifluoromethyl) benzyl] isoindolin-1-carboxamide; as well as a pharmaceutically acceptable salt, or an isomer thereof, or a salt of said isomer. The compounds of the invention are useful in therapy, such as pain therapy.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5731008P | 2008-05-30 | 2008-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071954A1 true AR071954A1 (en) | 2010-07-28 |
Family
ID=41377346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101936A AR071954A1 (en) | 2008-05-30 | 2009-05-29 | DERIVATIVES OF 3-OXO-ISOINDOL-1-CARBOXAMIDE USEFUL IN PAIN THERAPY AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM. |
Country Status (6)
Country | Link |
---|---|
AR (1) | AR071954A1 (en) |
CL (1) | CL2009001328A1 (en) |
PE (1) | PE20100052A1 (en) |
TW (1) | TW201000446A (en) |
UY (1) | UY31854A (en) |
WO (1) | WO2009145721A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8278302B2 (en) * | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
UA109290C2 (en) | 2010-10-07 | 2015-08-10 | Common Crystals and Salts of CCR3 Inhibitors | |
WO2012053186A1 (en) | 2010-10-18 | 2012-04-26 | Raqualia Pharma Inc. | Arylamide derivatives as ttx-s blockers |
AR090566A1 (en) | 2012-04-02 | 2014-11-19 | Boehringer Ingelheim Int | PROCESS FOR THE PRODUCTION OF CRR INHIBITORS |
US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
EP3558992A4 (en) | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | Activator of trek (twik related k+ channels) channels |
BR112021001608A2 (en) | 2018-09-10 | 2021-04-27 | Kaken Pharmaceutical Co., Ltd. | innovative heteroaromatic amide derivative and medicine containing the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6995144B2 (en) * | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
TW200613272A (en) * | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
GB0514017D0 (en) * | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
TW200812962A (en) * | 2006-07-12 | 2008-03-16 | Astrazeneca Ab | New compounds I/418 |
CN101490002A (en) * | 2006-07-12 | 2009-07-22 | 阿斯利康(瑞典)有限公司 | 3-oxoisoindoline-1-carboxamide derivatives as analgesic agents |
GB0705882D0 (en) * | 2007-03-27 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
-
2009
- 2009-05-26 TW TW098117487A patent/TW201000446A/en unknown
- 2009-05-29 CL CL2009001328A patent/CL2009001328A1/en unknown
- 2009-05-29 AR ARP090101936A patent/AR071954A1/en unknown
- 2009-05-29 UY UY0001031854A patent/UY31854A/en unknown
- 2009-05-29 PE PE2009000757A patent/PE20100052A1/en not_active Application Discontinuation
- 2009-05-29 WO PCT/SE2009/050618 patent/WO2009145721A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
UY31854A (en) | 2010-01-05 |
TW201000446A (en) | 2010-01-01 |
PE20100052A1 (en) | 2010-02-20 |
WO2009145721A1 (en) | 2009-12-03 |
CL2009001328A1 (en) | 2010-01-15 |
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