AR070895A1 - PROCESS FOR THE ELABORATION OF 2,3-DICLOROPIRIDINE - Google Patents

PROCESS FOR THE ELABORATION OF 2,3-DICLOROPIRIDINE

Info

Publication number
AR070895A1
AR070895A1 ARP090100912A AR070895A1 AR 070895 A1 AR070895 A1 AR 070895A1 AR P090100912 A ARP090100912 A AR P090100912A AR 070895 A1 AR070895 A1 AR 070895A1
Authority
AR
Argentina
Prior art keywords
salt
copper
amino
chloropyridine
hydrochloric acid
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Rafael Shapiro
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of AR070895A1 publication Critical patent/AR070895A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Método para preparar 2,3-dicloropiridina en el cual se hace reaccionar 3-amino-2-cloropiridina con una sal de nitrito en la presencia de ácido clorhídrico acuoso para formar una sal de diazonio; y la sal de diazonio se descompone luego en la presencia de ácido sulfámico y un catalizador de cobre en donde al menos un 50% aproximadamente del cobre se encuentra en el estado de oxidacion de cobre (lI). Reivindicacion 1: Un método para preparar 2,3-dicloropiridina (1), caracterizado porque comprende los pasos de: (1) hacer reaccionar 3-amino-2-cloropiridina (2) o una solucion que comprende 3-amino-2-cloropiridina (2) con ácido clorhídrico para formar una sal de ácido clorhídrico de 3- amino-2-cloropiridina; (2) hacer reaccionar la sal de ácido clorhídrico de 3-amino-2-cloropiridina con una sal de nitrito para formar la correspondiente sal de cloruro de diazonio; y (3) hacer reaccionar la correspondiente sal de cloruro de diazonio con ácido clorhídrico en la presencia de ácido sulfámico y un catalizador de cobre, en donde al menos un 50% aproximadamente del cobre es el estado de oxidacion de cobre (II), opcionalmente en la presencia de un solvente orgánico, para formar 2,3-dicloropiridina (1).Method for preparing 2,3-dichloropyridine in which 3-amino-2-chloropyridine is reacted with a nitrite salt in the presence of aqueous hydrochloric acid to form a diazonium salt; and the diazonium salt is then decomposed in the presence of sulfamic acid and a copper catalyst where at least about 50% of the copper is in the oxidation state of copper (lI). Claim 1: A method for preparing 2,3-dichloropyridine (1), characterized in that it comprises the steps of: (1) reacting 3-amino-2-chloropyridine (2) or a solution comprising 3-amino-2-chloropyridine (2) with hydrochloric acid to form a 3- amino-2-chloropyridine hydrochloric acid salt; (2) reacting the 3-amino-2-chloropyridine hydrochloric acid salt with a nitrite salt to form the corresponding diazonium chloride salt; and (3) reacting the corresponding diazonium chloride salt with hydrochloric acid in the presence of sulfamic acid and a copper catalyst, where at least about 50% of the copper is the oxidation state of copper (II), optionally in the presence of an organic solvent, to form 2,3-dichloropyridine (1).

ARP090100912 2008-03-13 2009-03-13 PROCESS FOR THE ELABORATION OF 2,3-DICLOROPIRIDINE AR070895A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3617408P 2008-03-13 2008-03-13

Publications (1)

Publication Number Publication Date
AR070895A1 true AR070895A1 (en) 2010-05-12

Family

ID=40834314

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100912 AR070895A1 (en) 2008-03-13 2009-03-13 PROCESS FOR THE ELABORATION OF 2,3-DICLOROPIRIDINE

Country Status (4)

Country Link
CN (1) CN101959862B (en)
AR (1) AR070895A1 (en)
TW (1) TW200946504A (en)
WO (1) WO2009114589A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE035506T2 (en) * 2010-08-04 2018-05-02 Daiichi Sankyo Co Ltd Process for preparing compound by novel sandmeyer-like reaction using nitroxide radical compound as reaction catalyst
JP5736201B2 (en) * 2011-03-15 2015-06-17 住友化学株式会社 Method for producing 2,3-dichloropyridine
CN103570609B (en) * 2013-10-28 2015-11-18 南通天泽化工有限公司 A kind of preparation method of 2,3-dichloropyridine
CN105399663B (en) * 2015-12-23 2018-09-14 山东天信化工有限公司 A method of preparing 2,3- dichloropyridines
CN108610282A (en) * 2018-05-03 2018-10-02 江苏医药职业学院 A method of passing through sandmeyer reaction catalyst preparation 2,3- dichloropyridines
CN110818621B (en) * 2018-08-08 2021-04-16 新发药业有限公司 Simple preparation method of 2, 3-dichloropyridine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI336325B (en) * 2004-01-23 2011-01-21 Du Pont Process for the manufacture of 2,3-dichloropyridine
CN100357272C (en) * 2006-02-06 2007-12-26 南京广通医药化工有限责任公司 2,3-dichloropyridine synthesis method

Also Published As

Publication number Publication date
CN101959862A (en) 2011-01-26
TW200946504A (en) 2009-11-16
WO2009114589A1 (en) 2009-09-17
CN101959862B (en) 2013-03-06

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