AR068925A1 - AN IMPROVED PROCESS TO PREPARE A DERIVATIVE OF 2.4. - TIAZOLIDINDIONA - Google Patents

AN IMPROVED PROCESS TO PREPARE A DERIVATIVE OF 2.4. - TIAZOLIDINDIONA

Info

Publication number
AR068925A1
AR068925A1 ARP080104553A ARP080104553A AR068925A1 AR 068925 A1 AR068925 A1 AR 068925A1 AR P080104553 A ARP080104553 A AR P080104553A AR P080104553 A ARP080104553 A AR P080104553A AR 068925 A1 AR068925 A1 AR 068925A1
Authority
AR
Argentina
Prior art keywords
solvates
rosiglitazone
prepare
maleate
rosiglitazone maleate
Prior art date
Application number
ARP080104553A
Other languages
Spanish (es)
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR068925A1 publication Critical patent/AR068925A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente se refiere a un proceso para preparar maleato de rosifglitazona con un bajo contenido de subproductos no deseados, el compuesto y su uso para preparar medicamentos para el tratamiento de la diabetes. Reivindicacion 1: Un proceso para preparar maleato de rosiglitazona y/o sus solvatos, el cual proporciona maleato de rosiglitazona y/o sus solvatos con una cantidad mínima de compuesto de Formula 2, comprendiendo dicho proceso las etapas de: (i) hacer reaccionar la rosiglitazona con ácido maleico en un solvente de alcohol C2-5 o mezclas de los mismos a una temperatura no superior a 78°C, (ii) opcionalmente, purificar el maleato de rosiglitazona obtenido y/o sus solvatos, y (iii) secar el maleato de rosiglitazona obtenido y/o sus solvatos.This refers to a process for preparing rosifglitazone maleate with a low content of unwanted by-products, the compound and its use to prepare medications for the treatment of diabetes. Claim 1: A process for preparing rosiglitazone maleate and / or its solvates, which provides rosiglitazone maleate and / or its solvates with a minimum amount of Formula 2 compound, said process comprising the steps of: (i) reacting the rosiglitazone with maleic acid in a C2-5 alcohol solvent or mixtures thereof at a temperature not exceeding 78 ° C, (ii) optionally, purify the rosiglitazone maleate obtained and / or its solvates, and (iii) dry the Rosiglitazone maleate obtained and / or its solvates.

ARP080104553A 2007-10-17 2008-10-17 AN IMPROVED PROCESS TO PREPARE A DERIVATIVE OF 2.4. - TIAZOLIDINDIONA AR068925A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98046607P 2007-10-17 2007-10-17

Publications (1)

Publication Number Publication Date
AR068925A1 true AR068925A1 (en) 2009-12-16

Family

ID=40567867

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080104553A AR068925A1 (en) 2007-10-17 2008-10-17 AN IMPROVED PROCESS TO PREPARE A DERIVATIVE OF 2.4. - TIAZOLIDINDIONA

Country Status (2)

Country Link
AR (1) AR068925A1 (en)
WO (1) WO2009050595A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102863436B (en) * 2012-06-19 2018-02-09 重庆医科大学 Tetrahydrothiazole diketone derivatives and its preparation and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741803A (en) * 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
EP1854794A1 (en) * 2006-05-09 2007-11-14 Teva Pharmaceutical Industries Ltd. 2-N-{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2-4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
US20070293546A1 (en) * 2006-06-15 2007-12-20 Srinivasula Reddy Maddula Preparation of rosiglitazone and its salts

Also Published As

Publication number Publication date
WO2009050595A3 (en) 2009-07-30
WO2009050595A2 (en) 2009-04-23

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