AR068536A1 - INACTIVATED ANTIGRIPAL VACCINE - Google Patents
INACTIVATED ANTIGRIPAL VACCINEInfo
- Publication number
- AR068536A1 AR068536A1 ARP080104130A ARP080104130A AR068536A1 AR 068536 A1 AR068536 A1 AR 068536A1 AR P080104130 A ARP080104130 A AR P080104130A AR P080104130 A ARP080104130 A AR P080104130A AR 068536 A1 AR068536 A1 AR 068536A1
- Authority
- AR
- Argentina
- Prior art keywords
- inactivated
- vaccine
- influenza
- virus
- influenza virus
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente se refiere a vacunas antigripales inactivadas y con adyuvantes. La presente brinda una vacuna que supera muchas de las desventajas de las vacunas antigripales inactivadas existentes. La presente brinda una vacuna antigripal inactivada, que comprende el virus de la influenza entero inactivado con beta propiolactona (BPL) y que comprende, como adyuvante, uno o más derivados de monosacáridos o disacáridos que tienen al menos uno pero no más de N-1 grupos éster de ácido graso y, opcionalmente, uno pero no más de N-1 grupos éster de sulfato, donde N es el numero de grupos hidroxilo del monosacárido o disacárido del cual se obtiene el derivado. El virus de la influenza en una vacuna de acuerdo con la presente se obtiene, preferentemente, de un cultivo celular. Los métodos para producir el virus de la influenza en un cultivo celular son conocidos en el arte. El virus se puede cultivar en células de origen mamífero, aviar; o humano, tales como células Madin Darby Canine Kidney (MDCK), Vero, MDBK, CLDK, EBx o PerC6.This refers to inactivated influenza vaccines and adjuvants. This provides a vaccine that overcomes many of the disadvantages of existing inactivated influenza vaccines. This provides an inactivated influenza vaccine, comprising the whole influenza virus inactivated with beta propiolactone (BPL) and comprising, as an adjuvant, one or more monosaccharide or disaccharide derivatives having at least one but not more than N-1 fatty acid ester groups and, optionally, one but not more than N-1 sulfate ester groups, where N is the number of hydroxyl groups of the monosaccharide or disaccharide from which the derivative is obtained. The influenza virus in a vaccine according to the present is preferably obtained from a cell culture. The methods for producing influenza virus in a cell culture are known in the art. The virus can be grown in cells of mammalian, avian origin; or human, such as Madin Darby Canine Kidney (MDCK), Vero, MDBK, CLDK, EBx or PerC6 cells.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97456807P | 2007-09-24 | 2007-09-24 | |
EP07117050 | 2007-09-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR068536A1 true AR068536A1 (en) | 2009-11-18 |
Family
ID=39590199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104130A AR068536A1 (en) | 2007-09-24 | 2008-09-24 | INACTIVATED ANTIGRIPAL VACCINE |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2195020A1 (en) |
CN (1) | CN101808659A (en) |
AR (1) | AR068536A1 (en) |
BR (1) | BRPI0817230A2 (en) |
TW (1) | TW200927928A (en) |
WO (1) | WO2009040343A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9278999B2 (en) | 2012-01-27 | 2016-03-08 | Newport Laboratories | Influenza C virus and vaccine |
EP3166957B1 (en) | 2014-07-11 | 2019-11-13 | National Research Council of Canada | Sulfated-glycolipids as adjuvants for vaccines |
CN104792985A (en) * | 2015-04-21 | 2015-07-22 | 乾元浩生物股份有限公司 | Method for qualitatively and quantitatively analyzing effective components of avian influenza virus antigen for poultry |
US20200289636A1 (en) * | 2017-09-07 | 2020-09-17 | Hawaii Biotech, Inc. | Filovirus vaccines and methods of use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1104767A1 (en) * | 1999-11-30 | 2001-06-06 | Stichting Dienst Landbouwkundig Onderzoek | Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups |
WO2007052155A2 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
-
2008
- 2008-09-19 TW TW097136110A patent/TW200927928A/en unknown
- 2008-09-23 CN CN200880108502A patent/CN101808659A/en active Pending
- 2008-09-23 BR BRPI0817230A patent/BRPI0817230A2/en not_active IP Right Cessation
- 2008-09-23 WO PCT/EP2008/062694 patent/WO2009040343A1/en active Application Filing
- 2008-09-23 EP EP08804610A patent/EP2195020A1/en not_active Withdrawn
- 2008-09-24 AR ARP080104130A patent/AR068536A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2009040343A1 (en) | 2009-04-02 |
TW200927928A (en) | 2009-07-01 |
CN101808659A (en) | 2010-08-18 |
BRPI0817230A2 (en) | 2017-06-06 |
EP2195020A1 (en) | 2010-06-16 |
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Legal Events
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FB | Suspension of granting procedure |