AR068032A1 - CHINOLONES REPLACED WITH USEFUL HETEROCICLICS AS INHIBITORS OF NITRICAL SYNTHEASE OXIDE - Google Patents
CHINOLONES REPLACED WITH USEFUL HETEROCICLICS AS INHIBITORS OF NITRICAL SYNTHEASE OXIDEInfo
- Publication number
- AR068032A1 AR068032A1 ARP080103693A ARP080103693A AR068032A1 AR 068032 A1 AR068032 A1 AR 068032A1 AR P080103693 A ARP080103693 A AR P080103693A AR P080103693 A ARP080103693 A AR P080103693A AR 068032 A1 AR068032 A1 AR 068032A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- halogen
- optionally substituted
- perfluoromethoxy
- perfluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un compuesto caracterizado porque tiene la formula estructural 1 o una de sus sales, ésteres o profármaco, en donde: X1 está seleccionado del grupo que consiste en CR4 y N; X2 está seleccionado del grupo que consiste en CR5 y N; X3 está seleccionado del grupo que consiste en CR6 y N; R4-R6 están seleccionados, de modo independiente, del grupo que consiste en hidrogeno, halogeno, ciano, alquilo inferior, haloalquilo inferior, haloalcoxi inferior, alquinilo inferior, cicloalquilo inferior, arilo inferior, heteroarilo inferior, (CH2)mOR12, (CH2)mSR13 y (CH2)mN(R14)R15, cualquiera de los cuales puede estar opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo que consiste en metilo, etilo, halogeno, perfluorometilo y perfluorometoxi; R7 está seleccionado del grupo que consiste en alquilo inferior, -(CH2)n- cicloalquilo inferior, -(CH2)n-heterocicloalquilo inferior, -(CH2)n-arilo inferior y -(CH2)n-heteroarilo inferior, cualquiera de los cuales puede estar opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo que consiste en metilo, etilo, halogeno, perfluorometilo y perfluorometoxi; R8, R9, R10 y R11 están seleccionados, de modo independiente, del grupo que consiste en hidrogeno, alquilo interior y halogeno; R12 y R13 están seleccionados, de modo independiente, del grupo que consiste en hidrogeno, halogeno, alquilo inferior, cicloalquilo inferior, arilo inferior, heteroarilo inferior, heterocicloalquilo inferior y heterocicloalquilalquilo inferior, cualquiera de los cuales puede estar opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo que consiste en metilo, etilo, halogeno, perfluorometilo y perfluorometoxi; R14 y R15 están seleccionados, de modo independiente, del grupo que consiste en hidrogeno, halogeno, alquilo inferior, cicloalquilo inferior, arilo inferior, heteroarilo inferior, heterocicloalquilo inferior y heterocicloalquilalquilo inferior, cualquiera de los cuales puede estar opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo que consiste en metilo, etilo, halogeno, perfluorometilo y perfluorometoxi; o R14 y R15, junto con el átomo al que están unidos se pueden juntar para formar un resto heterocicloalquilo opcionalmente sustituido de 3-7 miembros; y m y n son, de modo independiente, 0-4.Claim 1: A compound characterized in that it has the structural formula 1 or one of its salts, esters or prodrug, wherein: X1 is selected from the group consisting of CR4 and N; X2 is selected from the group consisting of CR5 and N; X3 is selected from the group consisting of CR6 and N; R4-R6 are independently selected from the group consisting of hydrogen, halogen, cyano, lower alkyl, lower haloalkyl, lower haloalkoxy, lower alkynyl, lower cycloalkyl, lower aryl, lower heteroaryl, (CH2) mOR12, (CH2) mSR13 and (CH2) mN (R14) R15, any of which may be optionally substituted with one or two substituents selected from the group consisting of methyl, ethyl, halogen, perfluoromethyl and perfluoromethoxy; R7 is selected from the group consisting of lower alkyl, - (CH2) n-lower cycloalkyl, - (CH2) lower n-heterocycloalkyl, - (CH2) lower n-aryl and - (CH2) lower n-heteroaryl, any of the which may be optionally substituted with one or two substituents selected from the group consisting of methyl, ethyl, halogen, perfluoromethyl and perfluoromethoxy; R8, R9, R10 and R11 are independently selected from the group consisting of hydrogen, inner alkyl and halogen; R12 and R13 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower cycloalkyl, lower aryl, lower heteroaryl, lower heterocycloalkyl and lower heterocycloalkylalkyl, any of which may be optionally substituted with one or two substituents selected from the group consisting of methyl, ethyl, halogen, perfluoromethyl and perfluoromethoxy; R14 and R15 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower cycloalkyl, lower aryl, lower heteroaryl, lower heterocycloalkyl and lower heterocycloalkylalkyl, any of which may be optionally substituted with one or two substituents selected from the group consisting of methyl, ethyl, halogen, perfluoromethyl and perfluoromethoxy; or R14 and R15, together with the atom to which they are attached can be joined to form an optionally substituted 3-7 membered heterocycloalkyl moiety; and m and n are, independently, 0-4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96815807P | 2007-08-27 | 2007-08-27 | |
| US5370908P | 2008-05-16 | 2008-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068032A1 true AR068032A1 (en) | 2009-10-28 |
Family
ID=39889675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103693A AR068032A1 (en) | 2007-08-27 | 2008-08-25 | CHINOLONES REPLACED WITH USEFUL HETEROCICLICS AS INHIBITORS OF NITRICAL SYNTHEASE OXIDE |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR068032A1 (en) |
| TW (1) | TW200924772A (en) |
| WO (1) | WO2009029592A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201311678A (en) | 2011-08-03 | 2013-03-16 | Kyowa Hakko Kirin Co Ltd | Dibenzooxepin derivative |
| KR101716993B1 (en) | 2012-12-25 | 2017-03-15 | 닛뽕소다 가부시키가이샤 | Halogenated aniline and method for producing same |
| KR20160143775A (en) | 2014-04-08 | 2016-12-14 | 더 메서디스트 하스피틀 | Inos-inhibitory compositions and their use as breast cancer therapeutics |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN1998000118A (en) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - AMINOPYRIDINES CONTAINING SUBSTITUTES FOR CONDENSED RINGS. |
| AU2006228142A1 (en) * | 2005-03-31 | 2006-10-05 | Nycomed Gmbh | Imidazopyridine derivatives useful as iNOS inhibitors |
| TW200803855A (en) * | 2006-02-24 | 2008-01-16 | Kalypsys Inc | Quinolones useful as inducible nitric oxide synthase inhibitors |
-
2008
- 2008-08-25 TW TW097132342A patent/TW200924772A/en unknown
- 2008-08-25 WO PCT/US2008/074251 patent/WO2009029592A1/en active Application Filing
- 2008-08-25 AR ARP080103693A patent/AR068032A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009029592A1 (en) | 2009-03-05 |
| TW200924772A (en) | 2009-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |