AR067788A1 - PROCESS FOR THE PREPARATION OF A POLYPEPTIDE FOR PHARMACEUTICAL USE - Google Patents

PROCESS FOR THE PREPARATION OF A POLYPEPTIDE FOR PHARMACEUTICAL USE

Info

Publication number
AR067788A1
AR067788A1 ARP080103370A ARP080103370A AR067788A1 AR 067788 A1 AR067788 A1 AR 067788A1 AR P080103370 A ARP080103370 A AR P080103370A AR P080103370 A ARP080103370 A AR P080103370A AR 067788 A1 AR067788 A1 AR 067788A1
Authority
AR
Argentina
Prior art keywords
protected
polypeptide
alanine
lysine
tyrosine
Prior art date
Application number
ARP080103370A
Other languages
Spanish (es)
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of AR067788A1 publication Critical patent/AR067788A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/36—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino acids, polyamines and polycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Un proceso para la preparacion de un polipéptido a partir de los aminoácidos L-alanina, ácido L-glutámico, L-lisina, y L-tirosina que comprende usar el N-tiocarboxianhidrido de al menos un aminoácido como material de partida. Reivindicacion 13: Un polipéptido o una sal del mismo aceptable para su uso farmacéutico, caracterizado porque comprende L-alanina, L-tirosina, L-glutamato, y L-lisina, que se prepara de acuerdo a un proceso que comprende los pasos de: a) polimerizar L-alanina, L-tirosina opcionalmente protegida, L-glutamato protegido, y L-lisina protegida para obtener un polipéptido protegido; y b) desproteger el polipéptido protegido para obtener el polipéptido o sal del mismo aceptable para su uso farmacéutico; en donde al menos uno de L-alanina, L-tirosina opcionalmente protegida, L-glutamato protegido, y L-lisina protegida es un N-tiocarboxianhidrido como se muestra en la formula 1, R representa la cadena lateral de L-alanina, L-tirosina opcionalmente protegida, L-glutamato protegido, y L-lisina protegida.A process for the preparation of a polypeptide from the amino acids L-alanine, L-glutamic acid, L-lysine, and L-tyrosine which comprises using the N-thiocarboxyanhydride of at least one amino acid as a starting material. Claim 13: A polypeptide or salt thereof acceptable for pharmaceutical use, characterized in that it comprises L-alanine, L-tyrosine, L-glutamate, and L-lysine, which is prepared according to a process comprising the steps of: a) polymerize L-alanine, optionally protected L-tyrosine, protected L-glutamate, and protected L-lysine to obtain a protected polypeptide; and b) deprotecting the protected polypeptide to obtain the polypeptide or salt thereof acceptable for pharmaceutical use; wherein at least one of L-alanine, optionally protected L-tyrosine, protected L-glutamate, and protected L-lysine is an N-thiocarboxyanhydride as shown in formula 1, R represents the side chain of L-alanine, L -optionally protected tyrosine, protected L-glutamate, and protected L-lysine.

ARP080103370A 2007-08-02 2008-08-01 PROCESS FOR THE PREPARATION OF A POLYPEPTIDE FOR PHARMACEUTICAL USE AR067788A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96302707P 2007-08-02 2007-08-02

Publications (1)

Publication Number Publication Date
AR067788A1 true AR067788A1 (en) 2009-10-21

Family

ID=40305134

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103370A AR067788A1 (en) 2007-08-02 2008-08-01 PROCESS FOR THE PREPARATION OF A POLYPEPTIDE FOR PHARMACEUTICAL USE

Country Status (3)

Country Link
US (1) US20090035816A1 (en)
AR (1) AR067788A1 (en)
WO (1) WO2009017775A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2277050B2 (en) 2008-04-16 2022-09-28 Momenta Pharmaceuticals, Inc. Analysis of amino acid copolymer compositions
WO2010017075A1 (en) 2008-08-07 2010-02-11 Sigma-Aldrich Co. Preparation of low molecular weight polylysine and polyornithine in high yield
AU2009279636A1 (en) * 2008-08-07 2010-02-11 Scinopharm Taiwan, Ltd. Synthesis of glatiramer acetate
ES2523732T5 (en) * 2009-04-03 2023-10-23 Momenta Pharmaceuticals Inc Control of copolymer compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) * 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
US4946942A (en) * 1988-03-11 1990-08-07 Bioresearch, Inc. Urethane-protected amino acid-N-carboxyanhydrides
US6686446B2 (en) * 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
CA2411786C (en) * 2002-11-13 2009-01-27 Brantford Chemicals Inc. A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids
CA2579656C (en) * 2004-09-09 2014-11-04 Teva Pharmaceutical Industries, Ltd. Process for preparation of mixtures of polypeptides using purified hydrobromic acid
JP5297653B2 (en) * 2004-10-29 2013-09-25 サンド・アクチエンゲゼルシヤフト Manufacturing method of glatiramer
UA93669C2 (en) * 2005-02-02 2011-03-10 Тева Фармасьютикл Индастриз, Лтд. Process for producing polypeptide mixtures using hydrogenolysis
CN101511862A (en) * 2006-07-05 2009-08-19 莫门塔制药股份有限公司 Improved process for the preparation of copolymer-1

Also Published As

Publication number Publication date
US20090035816A1 (en) 2009-02-05
WO2009017775A3 (en) 2009-04-30
WO2009017775A2 (en) 2009-02-05

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