AR067331A1 - PHARMACEUTICAL COMPOSITION DOSAGE FORM. NEW METHODS TO MASK FLAVOR - Google Patents
PHARMACEUTICAL COMPOSITION DOSAGE FORM. NEW METHODS TO MASK FLAVORInfo
- Publication number
- AR067331A1 AR067331A1 ARP080102531A ARP080102531A AR067331A1 AR 067331 A1 AR067331 A1 AR 067331A1 AR P080102531 A ARP080102531 A AR P080102531A AR P080102531 A ARP080102531 A AR P080102531A AR 067331 A1 AR067331 A1 AR 067331A1
- Authority
- AR
- Argentina
- Prior art keywords
- parasympathetic
- poly
- acid
- agents
- pharmaceutical composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Composicion farmacéutica con sabor enmascarado adecuada para su administracion oral, que comprende una mezcla granulada de un ingrediente farmacéutico activo y un componente de microesferas porosas, en el cual el ingrediente activo farmacéutico está incorporado en los poros de las microesferas porosas. Mctodo de tratamiento. Proceso. Reivindicacion 4: La composicion farmacéutica con sabor enmascarado de la reivindicacion 1 o 2, donde el componente de microesferas porosas se selecciona del grupo que consiste en poliésteres, poliamidas, polianhedridos, y poliacrilatos, ácido poli(láctico), ácido: poli(glicolico), ácido copoli(láctico/glicolico) y poli[ácido 1,3-bis(-p-carboxifenoxi)propan-co-sebácico], ácido poliglicolico (PGA) o poliláctico (PLA), copolemeros de glicolido y L(-láctido) (PGL), gelatina, agar, almidon, arabinogalactano, albumina, colágeno, materiales o polímeros naturales y sintéticos, tales como poli(epsilon-caprolactona), poli(epsilon-caprolactona-CO-ácido láctico), poli(epsilon-caprolactona-CO-ácido glicolico), poli(ácido beta-hidroxi buterico), oxido de polietileno, polietileno, poli(alquil-2-cianoacrilato) (por ejemplo, metil-, etil-, butil-2-cianoacrilato, etcétera), hidrogeles, tales como poli(metacrilato de hidroxietilo), poliamidas (por ejemplo, poliacrilamida), poli(arninoácidos) (es decir, L-leucina, L-ácido aspártico, beta-metil-L-aspartato, beta-bencil-L-aspartato, ácido glutámico, y semejantes), poli(2-hidroxietil DL-aspartamida), poli(éster de urea), poli(L- fenilalanina/etilenglicol/1,6-diisocianatohexano), poli(metacrilato de metilo), SephadexTM, SepharoseTM, y SuperoseTM, TrisacrilTM, UltrogelTM, medios ACATM, GF05TM y GF2000TM, medios SephacrilTM, medios SuperdexTM, tales como Superdex 75TM y Superdex 200TM, variantes de éstos, y combinaciones de éstos. Reivindicacion 5: La composicion farmacéutica con sabor enmascarado de la reivindicacion 1 o 2, donde el API se selecciona entre antibioticos, agentes antivirales, analgésicos, anestésicos, anoréxicos, antiartríticos, agentes antiasmáticos, anticonvulsivos, antidepresivos, agentes antidiabéticos, antidiarreicos, antihistamenicos, agentes antiinflamatorio, antinauseantes, antineoplásticos, drogas antiparkinsonismo, antiprureticos, antipsicnticos, antipiréticos, antiespasmodicos, antagonistas H2, antitusígenos, drogas cardiovasculares, antiarrítmicos, antihipertensivos, inhibidores de la ACE, diuréticos, vasodilatadores, hormonas, hipnoticos, inmunosupresores, relajantes musculares, parasimpatolíticos, parasimpátomiméticos, psicoestimulante, sedantes, agentes antimigrana, agentes antituberculosis, tranquilizantes, vitaminas y suplementos minerales. Reivindicacion 12: Una forma de dosificacion farmacéutica individual que comprende un complejo de API-microesferas porosas, donde la forma de dosificacion está recubierta con un recubrimiento aceptable para el uso farmacéutico. Reivindicacion 21: Una composicion farmacéutica que comprende un complejo de API-microesferas porosas, y que opcionalmente comprende además al menos un saborizante, y/o al menos un edulcorante, y/o al menos un recubrimiento.Pharmaceutical composition with masked flavor suitable for oral administration, comprising a granulated mixture of an active pharmaceutical ingredient and a porous microsphere component, in which the pharmaceutical active ingredient is incorporated into the pores of the porous microspheres. Method of treatment Process. Claim 4: The masked flavor pharmaceutical composition of claim 1 or 2, wherein the porous microsphere component is selected from the group consisting of polyesters, polyamides, polyanhedides, and polyacrylates, poly (lactic acid), acid: poly (glycolic) , copoly (lactic / glycolic acid) and poly [1,3-bis (-p-carboxyphenoxy) propan-co-sebacic acid], polyglycolic acid (PGA) or polylactic acid (PLA), glycolide co-polymers and L (-lactide) (PGL), gelatin, agar, starch, arabinogalactan, albumin, collagen, natural and synthetic materials or polymers, such as poly (epsilon-caprolactone), poly (epsilon-caprolactone-CO-lactic acid), poly (epsilon-caprolactone- CO-glycolic acid), poly (beta-hydroxy buteric acid), polyethylene oxide, polyethylene, poly (alkyl-2-cyanoacrylate) (for example, methyl-, ethyl-, butyl-2-cyanoacrylate, etc.), hydrogels, such as poly (hydroxyethyl methacrylate), polyamides (eg, polyacrylamide), poly (arnin oacids) (i.e., L-leucine, L-aspartic acid, beta-methyl-L-aspartate, beta-benzyl-L-aspartate, glutamic acid, and the like), poly (2-hydroxyethyl DL-aspartamide), poly ( urea ester), poly (L-phenylalanine / ethylene glycol / 1,6-diisocyanatohexane), poly (methyl methacrylate), SephadexTM, SepharoseTM, and SuperoseTM, TrisacrilTM, UltrogelTM, ACATM media, GF05TM and GF2000TM, SephacrilTM media, SuperdexTM media , such as Superdex 75TM and Superdex 200TM, variants thereof, and combinations thereof. Claim 5: The pharmaceutical composition with masked flavor of claim 1 or 2, wherein the API is selected from antibiotics, antiviral agents, analgesics, anesthetics, anorexics, antiarthritics, anti-asthmatic agents, anticonvulsants, antidepressants, anti-diabetic agents, anti-diarrheal agents, antihistamenic agents anti-inflammatory, anti-nauseating, anti-neoplastic drugs, anti-Parkinsonism, anti-purrotic, antipsychotic, antipyretic, antispasmodic, H2 antagonist, antitussive, cardiovascular drug, antiarrhythmic, antihypertensive, ACE inhibitors, diuretic, vasodilator, parasympathetic, muscle-parasympathetic, parasympathetic, parasympathetic, parasympathetic, parasympathetic, parasympathetic, parasympathetic, parasympathetic, parasympathetic, muscle, parasympathetic, parasympathetic, parasympathetic, parasympathetic, musculoskeletal, parasympathetic , psychostimulant, sedatives, antimigrane agents, antituberculosis agents, tranquilizers, vitamins and mineral supplements. Claim 12: An individual pharmaceutical dosage form comprising a complex of porous API-microspheres, wherein the dosage form is coated with a coating acceptable for pharmaceutical use. Claim 21: A pharmaceutical composition comprising a complex of porous API-microspheres, and optionally further comprising at least one flavor, and / or at least one sweetener, and / or at least one coating.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94366607P | 2007-06-13 | 2007-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067331A1 true AR067331A1 (en) | 2009-10-07 |
Family
ID=40156604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102531A AR067331A1 (en) | 2007-06-13 | 2008-06-13 | PHARMACEUTICAL COMPOSITION DOSAGE FORM. NEW METHODS TO MASK FLAVOR |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR067331A1 (en) |
WO (1) | WO2008157228A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2874824A1 (en) | 2012-07-23 | 2015-05-27 | Crayola LLC | Dissolvable films and methods of using the same |
CN102988546A (en) * | 2012-11-21 | 2013-03-27 | 徐曼丽 | Traditional Chinese medicine sachet used for refreshing |
CN105866308A (en) * | 2016-05-10 | 2016-08-17 | 芜湖雨耕山食品检测有限公司 | Method of utilizing gas chromatography to detect cyclamate |
EP3251661B1 (en) | 2016-05-30 | 2020-12-23 | Sun Pharmaceutical Industries Limited | Raloxifene sprinkle composition |
CN107083180B (en) * | 2017-05-25 | 2020-05-05 | 江南大学 | Self-cleaning reflective coating based on strawberry-type microspheres and preparation method thereof |
CN112315944B (en) * | 2020-12-08 | 2022-09-02 | 黄山中皇制药有限公司 | Preparation method of potassium dehydroandrographolide succinate enteric dry suspension |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6254854B1 (en) * | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
WO2005013944A1 (en) * | 2003-08-11 | 2005-02-17 | Merck Frosst Canada Ltd. | Flavored taste-masked pharmaceutical formulation made using a one-step coating process |
-
2008
- 2008-06-12 WO PCT/US2008/066701 patent/WO2008157228A1/en active Application Filing
- 2008-06-13 AR ARP080102531A patent/AR067331A1/en unknown
Also Published As
Publication number | Publication date |
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WO2008157228A1 (en) | 2008-12-24 |
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