AR067110A1 - COMBINED PHARMACEUTICAL COMPOSITION - Google Patents
COMBINED PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- AR067110A1 AR067110A1 ARP080102666A ARP080102666A AR067110A1 AR 067110 A1 AR067110 A1 AR 067110A1 AR P080102666 A ARP080102666 A AR P080102666A AR P080102666 A ARP080102666 A AR P080102666A AR 067110 A1 AR067110 A1 AR 067110A1
- Authority
- AR
- Argentina
- Prior art keywords
- cover
- pharmaceutical composition
- polymer
- plasticizer
- antioxidant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Composicion farmacéutica en cápsulas con microesferas recubiertas que comprende la combinacion de besilato de amlodipino y pravastatina sodica y sus sales farmacéuticamente aceptables, adicionalmente vehículos o excipientes farmacéuticamente aceptables; así como a un proceso para la fabricacion de la composicion y al uso de dicha combinacion para la preparacion de un medicamento con actividad terapéutica sinérgica indicado en el tratamiento de padecimientos cardiovasculares del tipo de hipertension arterial y dislipidemia y su comorbilidad. Reivindicacion 3: La composicion .farmacéutica de la reivindicacion 2 caracterizada: porque las microesferas recubiertas comprenden: Nucleos inertes; a) Cubierta uno, que incluye al principio activo uno, al menos un antioxidante, al menos un plastificante, al menos un amortiguador, y al menos un polímero adhesivo ligante aglutinante; b) Cubierta aislante que incluye, al menos un polímero en solucion acuosa; c) Cubierta que incluye al principio activo dos, al menos un antioxidante, al menos un plastificante, al menos un amortiguador, y al menos un polímero adhesivo ligante aglutinante; y d) Cubierta protectora de recubrimiento, que incluye al menos un polímero de recubrimiento y al menos un excipiente.Pharmaceutical composition in capsules with coated microspheres comprising the combination of amlodipine besylate and sodium pravastatin and its pharmaceutically acceptable salts, additionally pharmaceutically acceptable carriers or excipients; as well as a process for the manufacture of the composition and the use of said combination for the preparation of a medication with synergistic therapeutic activity indicated in the treatment of cardiovascular diseases of the type of arterial hypertension and dyslipidemia and their comorbidity. Claim 3: The pharmaceutical composition of claim 2 characterized in that the coated microspheres comprise: inert nuclei; a) Cover one, which includes the active ingredient one, at least one antioxidant, at least one plasticizer, at least one buffer, and at least one binding binder adhesive polymer; b) Insulating cover that includes at least one polymer in aqueous solution; c) Cover which includes at the active principle two, at least one antioxidant, at least one plasticizer, at least one buffer, and at least one binding binder adhesive polymer; and d) Protective coating cover, which includes at least one coating polymer and at least one excipient.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2007008440A MX2007008440A (en) | 2007-07-11 | 2007-07-11 | Combined pharmaceutical composition. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067110A1 true AR067110A1 (en) | 2009-09-30 |
Family
ID=40228222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102666A AR067110A1 (en) | 2007-07-11 | 2008-06-20 | COMBINED PHARMACEUTICAL COMPOSITION |
Country Status (7)
Country | Link |
---|---|
AR (1) | AR067110A1 (en) |
CL (1) | CL2008001895A1 (en) |
MX (1) | MX2007008440A (en) |
PA (1) | PA8785701A1 (en) |
PE (1) | PE20090439A1 (en) |
UY (1) | UY31153A1 (en) |
WO (1) | WO2009007808A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101804055B (en) * | 2010-04-27 | 2012-01-25 | 施慧达药业集团(吉林)有限公司 | Compound medicinal preparation |
MX351059B (en) * | 2012-08-17 | 2017-09-29 | Laboratorios Senosiain S A De C V Star | Oral pharmaceutical composition in the form of microspheres and preparation method. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL133957A0 (en) * | 1997-08-29 | 2001-04-30 | Pfizer Prod Inc | Combination therapy comprising amlodipine and a statin compound |
CA2420844A1 (en) * | 2000-08-30 | 2003-02-28 | Sankyo Company, Limited | Medicinal compositions for preventing or treating heart failure |
-
2007
- 2007-07-11 MX MX2007008440A patent/MX2007008440A/en active IP Right Grant
-
2008
- 2008-06-13 UY UY31153A patent/UY31153A1/en not_active Application Discontinuation
- 2008-06-14 WO PCT/IB2008/001538 patent/WO2009007808A1/en active Application Filing
- 2008-06-20 AR ARP080102666A patent/AR067110A1/en unknown
- 2008-06-25 PA PA20088785701A patent/PA8785701A1/en unknown
- 2008-06-26 CL CL200801895A patent/CL2008001895A1/en unknown
- 2008-07-09 PE PE2008001152A patent/PE20090439A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CL2008001895A1 (en) | 2008-08-22 |
WO2009007808A1 (en) | 2009-01-15 |
WO2009007808A4 (en) | 2009-03-05 |
MX2007008440A (en) | 2009-02-18 |
UY31153A1 (en) | 2009-03-02 |
PE20090439A1 (en) | 2009-05-24 |
PA8785701A1 (en) | 2009-04-23 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |