AR067048A1 - ACETAMINOFEN WATERY FORMULATIONS FOR INJECTION. - Google Patents

ACETAMINOFEN WATERY FORMULATIONS FOR INJECTION.

Info

Publication number
AR067048A1
AR067048A1 ARP080102597A ARP080102597A AR067048A1 AR 067048 A1 AR067048 A1 AR 067048A1 AR P080102597 A ARP080102597 A AR P080102597A AR P080102597 A ARP080102597 A AR P080102597A AR 067048 A1 AR067048 A1 AR 067048A1
Authority
AR
Argentina
Prior art keywords
injection
acetaminofen
watery
formulations
acetaminophen
Prior art date
Application number
ARP080102597A
Other languages
Spanish (es)
Inventor
Pena Agnes Fernandez
Lloret Sergio Perez
Original Assignee
Combino Pharm Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combino Pharm Sl filed Critical Combino Pharm Sl
Publication of AR067048A1 publication Critical patent/AR067048A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Reivindicacion 1: Una formulacion acuosa estable de acetaminofén para inyeccion, caracterizada porque comprende: a) entre aproximadamente 200,0 mg y aproximadamente 1.400,0 mg de acetaminofén; b) entre aproximadamente 200,0 mg y aproximadamente 10.000,0 mg de manitol para inyeccion; c) entre aproximadamente 0,0 mg y aproximadamente 30,0 mg de fosfato de sodio monobásico; d) entre aproximadamente 0,0 mg y aproximadamente 300,0 mg de povidona; e) una cantidad suficiente de hidroxido de sodio y ácido clorhídrico segun se necesite para ajustar el pH entre aproximadamente 4,0 y aproximadamente 8,0; y f) un volumen de agua para inyeccion hasta un volumen de aproximadamente 100 mL.Claim 1: A stable aqueous formulation of acetaminophen for injection, characterized in that it comprises: a) between about 200.0 mg and about 1,400.0 mg of acetaminophen; b) between about 200.0 mg and about 10,000.0 mg of mannitol for injection; c) between about 0.0 mg and about 30.0 mg of monobasic sodium phosphate; d) between about 0.0 mg and about 300.0 mg of povidone; e) a sufficient amount of sodium hydroxide and hydrochloric acid as needed to adjust the pH between about 4.0 and about 8.0; and f) a volume of water for injection to a volume of approximately 100 mL.

ARP080102597A 2007-06-18 2008-06-18 ACETAMINOFEN WATERY FORMULATIONS FOR INJECTION. AR067048A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92919207P 2007-06-18 2007-06-18

Publications (1)

Publication Number Publication Date
AR067048A1 true AR067048A1 (en) 2009-09-30

Family

ID=40429866

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102597A AR067048A1 (en) 2007-06-18 2008-06-18 ACETAMINOFEN WATERY FORMULATIONS FOR INJECTION.

Country Status (3)

Country Link
EP (1) EP2170313A2 (en)
AR (1) AR067048A1 (en)
WO (1) WO2009047634A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2243477A1 (en) * 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol for parenteral application
WO2011071400A1 (en) * 2009-12-10 2011-06-16 Tecnimede - Sociedade Técnico-Medicinal, S.A. Method and composition for preparing stable liquid formulations of paracetamol
EP2377516B1 (en) 2010-04-14 2012-06-20 B. Braun Melsungen AG Acetaminophen composition
BR112012031928B1 (en) * 2010-06-30 2021-08-31 Troikaa Pharmaceuticals Ltd Pharmaceutical compositions which include paracetamol and process for preparing the same
ZA201300398B (en) * 2012-11-27 2013-09-25 Genfarma Laboratories S L Injectable liquid formulation of the combination of tramadol and paracetamol
SG11201704435PA (en) 2014-12-20 2017-06-29 Troikaa Pharmaceuticals Ltd Injectable formulations of paracetamol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751875B1 (en) * 1996-08-05 1998-12-24 Scr Newpharm NOVEL STABLE LIQUID FORMULATIONS BASED ON PARACETAMOL AND THEIR METHOD OF PREPARATION
FR2809619B1 (en) * 2000-06-06 2004-09-24 Pharmatop NOVEL AQUEOUS FORMULATIONS OF OXIDATION-SENSITIVE ACTIVE INGREDIENTS AND PROCESS FOR OBTAINING THEM
FR2851164B1 (en) * 2003-02-14 2005-04-22 Xuan Tho Nguyen INFLATABLE LIQUID FORMULATION OF PARACETAMOL
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
EP1992334A1 (en) * 2007-05-08 2008-11-19 Docpharma NV/SA Storage-stable formulation of oxidation-sensitive phenolic drug, especially paracetamol, comprises aqueous drug solution deoxygenated by a temperature-controlled manufacturing process of the formulation

Also Published As

Publication number Publication date
WO2009047634A2 (en) 2009-04-16
WO2009047634A3 (en) 2009-06-04
EP2170313A2 (en) 2010-04-07

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