AR066776A1 - DIAZENODIOLATE DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

DIAZENODIOLATE DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
AR066776A1
AR066776A1 ARP080102278A ARP080102278A AR066776A1 AR 066776 A1 AR066776 A1 AR 066776A1 AR P080102278 A ARP080102278 A AR P080102278A AR P080102278 A ARP080102278 A AR P080102278A AR 066776 A1 AR066776 A1 AR 066776A1
Authority
AR
Argentina
Prior art keywords
group
worth
branched
linear
diazenodiolate
Prior art date
Application number
ARP080102278A
Other languages
Spanish (es)
Inventor
Serge Simonet
Laure Haberkorn
Alexis Cordi
Tony Verbeuren
Christine Courchay
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR066776A1 publication Critical patent/AR066776A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicacion 1: Compuestos de formula: G(CH2)n-A-(CH2)m-(CR1R2)p-(CH2)o-R3 en la que: - n vale 0, 1, 2 o 3, - m vale 0, 1, 2 o 3, - p vale 0 o 1, - o vale 0, 1 o 2, - R1 y R2, idénticos o diferentes, representan cada uno un átomo de hidrogeno o un grupo alquilo (C1-6) lineal o ramificado, - entendiéndose que uno de los grupos -CH2- o -CR1R2- de la formula G(CH2)n-A-(CH2)m-(CR1R2)p-(CH2)o-R3 puede reemplazarse igualmente por un grupo fenileno, -PhC(O)- o -PhC(O)O- (en el que Ph significa el radical fenilo), - A representa un grupo (1) en los que R4 representa un átomo de hidrogeno o un grupo alquilo (C1-6) lineal o ramificado, - R3 representa un grupo (2) en el que R5, R6 y R7, idénticos o diferentes, representan cada uno un átomo de hidrogeno o un grupo alquilo (C1-6) lineal o ramificado, o R5 y R6 forman juntos una cadena alquileno (C1-6) lineal o ramificada, - y G representa un grupo de formula (3) sus enantiomeros y diastereoisomeros así como sus sales de adicion a un ácido o a una base aceptable farmacéuticamente.Claim 1: Compounds of formula: G (CH2) nA- (CH2) m- (CR1R2) p- (CH2) o-R3 wherein: - n is worth 0, 1, 2 or 3, - m is worth 0, 1 , 2 or 3, - p is worth 0 or 1, - or is worth 0, 1 or 2, - R1 and R2, identical or different, each represent a hydrogen atom or a linear or branched (C1-6) alkyl group, - it being understood that one of the groups -CH2- or -CR1R2- of the formula G (CH2) nA- (CH2) m- (CR1R2) p- (CH2) or -R3 can also be replaced by a phenylene group, -PhC ( O) - or -PhC (O) O- (where Ph means the phenyl radical), - A represents a group (1) in which R4 represents a hydrogen atom or a linear (C1-6) alkyl group or branched, - R3 represents a group (2) in which R5, R6 and R7, identical or different, each represent a hydrogen atom or a linear or branched (C1-6) alkyl group, or R5 and R6 together form a linear or branched (C1-6) alkylene chain, - and G represents a group of formula (3) its enantiomers and diastereoisomers as well as its acid addition salts or or to a pharmaceutically acceptable base.

ARP080102278A 2007-05-30 2008-05-30 DIAZENODIOLATE DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AR066776A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0703815A FR2916757B1 (en) 2007-05-30 2007-05-30 NOVEL DIAZENIUMDIOLATE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Publications (1)

Publication Number Publication Date
AR066776A1 true AR066776A1 (en) 2009-09-09

Family

ID=39004844

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102278A AR066776A1 (en) 2007-05-30 2008-05-30 DIAZENODIOLATE DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (3)

Country Link
AR (1) AR066776A1 (en)
FR (1) FR2916757B1 (en)
WO (1) WO2009004164A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354394B2 (en) * 2009-10-29 2013-01-15 Merck Sharp & Dohme Corp. Diuretics
JP2014508742A (en) * 2011-01-19 2014-04-10 メルク・シャープ・アンド・ドーム・コーポレーション Diazeniumdiolate derivatives
JO3350B1 (en) 2011-03-07 2019-03-13 Merck Sharp & Dohme Heterocyclic derivatives containing primary amino groups and diazeniumdiolates
US11148999B2 (en) * 2016-06-22 2021-10-19 MedChem Partners, LLC Nitric oxide donors
CN109608371B (en) * 2019-01-16 2020-12-29 泰州学院 O2-4- (3- (4-sulfamoylphenyl) urea) phenylazoium dialkoxide derivative, preparation method and application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9210098B (en) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoles, drugs with this compounds, and process for their preparation
ATE283267T1 (en) * 1996-09-27 2004-12-15 Us Gov Health & Human Serv O2-ARYLATE OR O2 GLYCOSYIATE 1-SUBSTITUTED DIAZENE-1-IUM-1,2-DIOLATE AND O2-SUBSTITUTED 1(2-CARBOXYLATE) PYROLIDINE-1-YL DIAZENE-1-IUM-1,2-DIOLATE
JP2008535928A (en) * 2005-04-12 2008-09-04 シヴィダ・インコーポレイテッド HMGCoA reductase inhibitor combinations and uses thereof

Also Published As

Publication number Publication date
FR2916757A1 (en) 2008-12-05
WO2009004164A2 (en) 2009-01-08
WO2009004164A9 (en) 2010-03-18
FR2916757B1 (en) 2009-07-17
WO2009004164A3 (en) 2009-04-30

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