AR066261A1 - BENZOXASOL COMPOUNDS - Google Patents

BENZOXASOL COMPOUNDS

Info

Publication number
AR066261A1
AR066261A1 ARP080101704A ARP080101704A AR066261A1 AR 066261 A1 AR066261 A1 AR 066261A1 AR P080101704 A ARP080101704 A AR P080101704A AR P080101704 A ARP080101704 A AR P080101704A AR 066261 A1 AR066261 A1 AR 066261A1
Authority
AR
Argentina
Prior art keywords
straight
independently
compound
branched chain
alkyl
Prior art date
Application number
ARP080101704A
Other languages
Spanish (es)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR066261A1 publication Critical patent/AR066261A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Abstract

La presente revelacion se encuentra enfocada a los compuestos benzoxazol que son ligandos en el receptor NPY Y5. Además proporciona una composicion farmacéutica que comprende una cantidad terapéuticamente eficaz de un compuesto de la invencion y unvehículo aceptable desde el punto de vista farmacéutico. También proporciona un método de tratamiento a un sujeto que padece depresion, ansiedad u obesidad que comprende administrar al sujeto una cantidad de un compuesto de la invencion en cuestion.Además, también proporciona el uso de un compuesto de la invencion para la preparacion de un medicamento para tratar a un sujeto que padece depresion, ansiedad u obesidad. Reivindicacion 1: Un compuesto que tiene la estructura: (1) donde cada R1 esde manera independiente F, CI, Br, I, -CN, -COR3, -CO2R3, alquilo C1-7 o perfluoroalquilo C1-7 de cadena recta o ramificado, alcoxi C1-7 o perfluoroalcoxi C1-7 de cadena recta o ramificada, o fenilo opcionalmente sustituido con uno o más R4 donde R2es cicloalquilo C3-6, donde cada R3 es de manera independiente H o alquilo C1-7 de cadena recta o ramificada; donde cada R4 es de manera independiente F, CI, Br, I o alquilo C1-7 de cadena recta o ramificada; donde cada R5 es de manera independienteF, CI, Br, I, alquilo C1-7 de cadena recta o ramificada o alcoxi C1-7 de cadena recta o ramificada; donde A es la formulas (2), (3) y (4) donde n es un entero de 0 a 4 inclusive; donde p es un entero de 0 a 2 inclusive; y donde q es un entero de 0 a2 inclusive; o una de su sal aceptable desde el punto de vista farmacéutico.The present disclosure is focused on benzoxazole compounds that are ligands in the NPY Y5 receptor. It also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable vehicle. It also provides a method of treatment to a subject suffering from depression, anxiety or obesity which comprises administering to the subject an amount of a compound of the invention in question.In addition, it also provides the use of a compound of the invention for the preparation of a medicament. to treat a subject suffering from depression, anxiety or obesity. Claim 1: A compound having the structure: (1) wherein each R1 is independently F, CI, Br, I, -CN, -COR3, -CO2R3, C1-7 alkyl or C1-7 straight or branched chain perfluoroalkyl , C1-7 alkoxy or C1-7 straight or branched chain perfluoroalkoxy, or phenyl optionally substituted with one or more R4 where R2 is C3-6 cycloalkyl, where each R3 is independently H or C1-7 straight or branched chain alkyl ; where each R4 is independently F, CI, Br, I or C1-7 straight or branched chain alkyl; where each R5 is independently F, CI, Br, I, straight or branched C1-7 alkyl or straight or branched C1-7 alkoxy; where A is the formulas (2), (3) and (4) where n is an integer from 0 to 4 inclusive; where p is an integer from 0 to 2 inclusive; and where q is an integer from 0 to 2 inclusive; or one of its pharmaceutically acceptable salt.

ARP080101704A 2007-04-30 2008-04-23 BENZOXASOL COMPOUNDS AR066261A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91483207P 2007-04-30 2007-04-30

Publications (1)

Publication Number Publication Date
AR066261A1 true AR066261A1 (en) 2009-08-05

Family

ID=39926030

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101704A AR066261A1 (en) 2007-04-30 2008-04-23 BENZOXASOL COMPOUNDS

Country Status (3)

Country Link
AR (1) AR066261A1 (en)
CL (1) CL2008001261A1 (en)
WO (1) WO2008134228A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0710950A2 (en) 2006-04-28 2012-06-26 Shionogi & Co amine derivative having npi 53 y5 receptor antagonistic activity a61p 3/04 a61p 9/04 a61p 9/12 a61p 15/00 a61p 25/08 a61p 25/20 a61p 25/24 a61p 43/00 c07c 311/07 c07c 317 / 36 c07d 207/325 c07d 211/14 c07d 213/38 c07d 213/74 c07d 213/82 c07d 215/38 c07d 217/04 c07d 217/14 c07d 217/22 c07d 219/10 c07d 231/38 c07d 233/61 c07d 235/30 c07d 237/20 c07d 237/22 c07d 237/34 c07d 239/42 c07d 241/20 c07d 261/14 c07d 261/20 c07d 263/58 c07d 265/30 c07d 265/36 c07d 267/14 c07d 275 / 02 c07d 277/28 c07d 277/62 c07d 277/82 c07d 295/12 c07d 295/18 c07d 333/36 c07d 333/40 c07d 333/66 c07d 333/72 c07d 403/04 c07d 409/04 c07d 413/04 c07d 417/12 c07d 498/04 c07d 513/04
SA08290668B1 (en) 2007-10-25 2012-02-12 شيونوجي آند كو.، ليمتد Amine Derivatives having NPY Y5 receptor antagonistic activity and the uses thereof
JP5131783B2 (en) * 2009-04-23 2013-01-30 塩野義製薬株式会社 Amine derivatives having NPYY5 receptor antagonistic activity and uses thereof
US8227618B2 (en) 2009-04-23 2012-07-24 Shionogi & Co., Ltd. Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof
BR112012012948A2 (en) 2009-11-25 2015-09-08 Shionogi & Co process for the preparation of cyclohexane derivatives
WO2011132075A2 (en) * 2010-04-23 2011-10-27 Shionogi & Company, Ltd. A hydrate of a cyclohexanamine derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284759B1 (en) * 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
EP1345914A1 (en) * 2000-12-22 2003-09-24 AstraZeneca AB Therapeutic compounds

Also Published As

Publication number Publication date
WO2008134228A1 (en) 2008-11-06
CL2008001261A1 (en) 2009-03-06

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