AR063372A1 - CHROMAN DERIVATIVES, THEIR SYNTHESIS AND INTERMEDIARIES - Google Patents

CHROMAN DERIVATIVES, THEIR SYNTHESIS AND INTERMEDIARIES

Info

Publication number
AR063372A1
AR063372A1 ARP070104704A ARP070104704A AR063372A1 AR 063372 A1 AR063372 A1 AR 063372A1 AR P070104704 A ARP070104704 A AR P070104704A AR P070104704 A ARP070104704 A AR P070104704A AR 063372 A1 AR063372 A1 AR 063372A1
Authority
AR
Argentina
Prior art keywords
independently
intermediaries
synthesis
halogen
compound
Prior art date
Application number
ARP070104704A
Other languages
Spanish (es)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR063372A1 publication Critical patent/AR063372A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Abstract

Los compuestos, y las composiciones que contienen los compuestos, se pueden usar para tratar una variedad de trastornos del SNC, tales como la esquizofrenia. Reivindicacion 1: Un método para preparar un compuesto de formula (1) donde: x es de 0 a 3; y es de 0 a 5; cada R1 es independientemente -R, -CN, halogeno o -OR; cada R2 es independientemente -Ph, halogeno, -CN, -R o -OR; y cada R es independientemente hidrogeno, alifático C1-6 o haloalifático C1-6; que comprende los pasos de: (a) proporcionar un compuesto de formula (2): donde: x es de 0 a 3; y es de 0 a 5; cada R1 es independientemente -R, -CN, halogeno o -OR; cada R2 es independientemente -Ph, halogeno, -CN, -R o -OR; y cada R es independientemente hidrogeno, alifático C1- 6 o haloalifático C1-6; y (b) reducir dicho compuesto de formula (2) para proporcionar dicho compuesto de formula (1).The compounds, and the compositions containing the compounds, can be used to treat a variety of CNS disorders, such as schizophrenia. Claim 1: A method for preparing a compound of formula (1) wherein: x is 0 to 3; and is 0 to 5; each R1 is independently -R, -CN, halogen or -OR; each R2 is independently -Ph, halogen, -CN, -R or -OR; and each R is independently hydrogen, C1-6 aliphatic or C1-6 haloaliphatic; comprising the steps of: (a) providing a compound of formula (2): where: x is from 0 to 3; and is 0 to 5; each R1 is independently -R, -CN, halogen or -OR; each R2 is independently -Ph, halogen, -CN, -R or -OR; and each R is independently hydrogen, C1-6 aliphatic or C1-6 haloaliphatic; and (b) reducing said compound of formula (2) to provide said compound of formula (1).

ARP070104704A 2006-10-25 2007-10-24 CHROMAN DERIVATIVES, THEIR SYNTHESIS AND INTERMEDIARIES AR063372A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85438206P 2006-10-25 2006-10-25

Publications (1)

Publication Number Publication Date
AR063372A1 true AR063372A1 (en) 2009-01-21

Family

ID=39029809

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104704A AR063372A1 (en) 2006-10-25 2007-10-24 CHROMAN DERIVATIVES, THEIR SYNTHESIS AND INTERMEDIARIES

Country Status (5)

Country Link
AR (1) AR063372A1 (en)
CL (1) CL2007003066A1 (en)
PE (1) PE20081139A1 (en)
TW (1) TW200831478A (en)
WO (1) WO2008052088A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100266504A1 (en) 2007-11-15 2010-10-21 Takahiro Matsumoto Condensed pyridine derivative and use thereof
WO2011071136A1 (en) 2009-12-11 2011-06-16 アステラス製薬株式会社 Therapeutic agent for fibromyalgia
CN102329199B (en) * 2011-07-19 2014-04-02 黑龙江大学 Method for synthesizing biphenyl compounds under composite catalytic actions of Pd/C and crown ether
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN103553859B (en) * 2013-11-14 2015-09-16 竺叶洪 A kind of method being prepared aminated compounds intermediate by acid amides
CN104591939B (en) * 2015-01-31 2016-06-15 台州学院 A kind of method preparing xenyl acrylic acid ether compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (en) * 1991-10-28 1993-04-29 Bayer Ag 2-AMINOMETHYL-chromans
WO2003029239A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
EP1432696A1 (en) * 2001-10-04 2004-06-30 Wyeth Chroman derivatives as 5-hydroxytryptamine-6 ligands
US6667322B2 (en) * 2001-10-05 2003-12-23 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
MX2007013163A (en) * 2005-04-22 2008-01-21 Wyeth Corp Chromane and chromene derivatives and uses thereof.

Also Published As

Publication number Publication date
TW200831478A (en) 2008-08-01
WO2008052088A8 (en) 2008-09-25
PE20081139A1 (en) 2008-09-18
CL2007003066A1 (en) 2008-01-25
WO2008052088A1 (en) 2008-05-02

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