AR062217A1 - Derivados de 4- trimetilamonio-3- aminobutirato y 4- trimetilfosfonio-3-aminobutirato como inhibidores de la cpt - Google Patents
Derivados de 4- trimetilamonio-3- aminobutirato y 4- trimetilfosfonio-3-aminobutirato como inhibidores de la cptInfo
- Publication number
- AR062217A1 AR062217A1 ARP070103457A ARP070103457A AR062217A1 AR 062217 A1 AR062217 A1 AR 062217A1 AR P070103457 A ARP070103457 A AR P070103457A AR P070103457 A ARP070103457 A AR P070103457A AR 062217 A1 AR062217 A1 AR 062217A1
- Authority
- AR
- Argentina
- Prior art keywords
- aminobutirate
- trimethylammon
- trimethylphosphonio
- cpt
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003345 hyperglycaemic effect Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06118338 | 2006-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062217A1 true AR062217A1 (es) | 2008-10-22 |
Family
ID=37395789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103457A AR062217A1 (es) | 2006-08-02 | 2007-08-06 | Derivados de 4- trimetilamonio-3- aminobutirato y 4- trimetilfosfonio-3-aminobutirato como inhibidores de la cpt |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090312286A1 (enExample) |
| EP (1) | EP2046734A1 (enExample) |
| JP (1) | JP2009545549A (enExample) |
| KR (1) | KR20090034969A (enExample) |
| CN (1) | CN101511780A (enExample) |
| AR (1) | AR062217A1 (enExample) |
| AU (1) | AU2007280604A1 (enExample) |
| BR (1) | BRPI0715084A2 (enExample) |
| CA (1) | CA2658797A1 (enExample) |
| EA (1) | EA200970170A1 (enExample) |
| IL (1) | IL196594A0 (enExample) |
| MX (1) | MX2009001104A (enExample) |
| SG (1) | SG174032A1 (enExample) |
| TW (1) | TW200815326A (enExample) |
| WO (1) | WO2008015081A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2680366C (en) * | 2007-03-09 | 2016-06-21 | University Health Network | Inhibitors of carnitine palmitoyltransferase and treating cancer |
| CA2677049A1 (en) | 2007-08-01 | 2009-02-05 | Sionex Corporation | Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| MX2010008196A (es) * | 2008-04-29 | 2010-08-11 | Hoffmann La Roche | Derivados de acido 4-dimetilaminobutirico. |
| ES2525340T3 (es) * | 2008-04-29 | 2014-12-22 | F. Hoffmann-La Roche Ag | 4-butiratos de trimetilamonio como inhibidores de la CPT2 |
| US8957032B2 (en) * | 2008-05-06 | 2015-02-17 | Alba Therapeutics Corporation | Inhibition of gliadin peptides |
| EP2309859A4 (en) * | 2008-06-24 | 2011-09-07 | Dara Biosciences Inc | ENZYME INHIBITORS AND USE THEREOF |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3476656D1 (en) | 1983-05-25 | 1989-03-16 | Takeda Chemical Industries Ltd | Derivatives of beta-amino-gamma-trimethylammonio-butyrate, their production and use |
| HUT65327A (en) | 1992-06-11 | 1994-05-02 | Sandoz Ag | Process for producing phosphinyloxy-propyl-ammonium inner sact derwatives ang pharmateutical preparations containing them |
| IT1299266B1 (it) | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
-
2007
- 2007-07-10 KR KR1020097002824A patent/KR20090034969A/ko not_active Withdrawn
- 2007-07-10 EP EP07787305A patent/EP2046734A1/en not_active Withdrawn
- 2007-07-10 US US12/374,774 patent/US20090312286A1/en not_active Abandoned
- 2007-07-10 JP JP2009522200A patent/JP2009545549A/ja not_active Withdrawn
- 2007-07-10 MX MX2009001104A patent/MX2009001104A/es not_active Application Discontinuation
- 2007-07-10 WO PCT/EP2007/057030 patent/WO2008015081A1/en not_active Ceased
- 2007-07-10 CN CNA200780032448XA patent/CN101511780A/zh active Pending
- 2007-07-10 AU AU2007280604A patent/AU2007280604A1/en not_active Abandoned
- 2007-07-10 SG SG2011055696A patent/SG174032A1/en unknown
- 2007-07-10 CA CA002658797A patent/CA2658797A1/en not_active Abandoned
- 2007-07-10 EA EA200970170A patent/EA200970170A1/ru unknown
- 2007-07-10 BR BRPI0715084-9A patent/BRPI0715084A2/pt not_active IP Right Cessation
- 2007-08-02 TW TW096128440A patent/TW200815326A/zh unknown
- 2007-08-06 AR ARP070103457A patent/AR062217A1/es not_active Application Discontinuation
-
2009
- 2009-01-19 IL IL196594A patent/IL196594A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007280604A1 (en) | 2008-02-07 |
| WO2008015081A1 (en) | 2008-02-07 |
| JP2009545549A (ja) | 2009-12-24 |
| BRPI0715084A2 (pt) | 2013-03-12 |
| MX2009001104A (es) | 2009-02-10 |
| US20090312286A1 (en) | 2009-12-17 |
| EP2046734A1 (en) | 2009-04-15 |
| IL196594A0 (en) | 2009-11-18 |
| KR20090034969A (ko) | 2009-04-08 |
| CN101511780A (zh) | 2009-08-19 |
| SG174032A1 (en) | 2011-09-29 |
| EA200970170A1 (ru) | 2009-06-30 |
| CA2658797A1 (en) | 2008-02-07 |
| TW200815326A (en) | 2008-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR062217A1 (es) | Derivados de 4- trimetilamonio-3- aminobutirato y 4- trimetilfosfonio-3-aminobutirato como inhibidores de la cpt | |
| SG178952A1 (en) | Chemical compounds | |
| MX2011012122A (es) | Derivados de tiofeno. | |
| EA201290416A1 (ru) | Новые спиропиперидиновые соединения | |
| EA201101672A1 (ru) | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина | |
| EA201190235A1 (ru) | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 | |
| EA201391000A1 (ru) | Индольные соединения или их аналоги, полезные для лечения возрастной макулярной дегенерации (amd) | |
| EA200870423A1 (ru) | Производные триазолпиразинов, применимые в качестве противораковых агентов | |
| EA200870193A1 (ru) | Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение | |
| EA200500203A1 (ru) | Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат | |
| EA201270216A1 (ru) | Фармацевтический состав | |
| EA200801997A1 (ru) | Новые соединения | |
| EA201391288A1 (ru) | Производные пиразолоспирокетонов для применения в качестве ингибиторов ацетил-коа-карбоксилаз | |
| BR112014023384A2 (pt) | inibidores de bace de di-hidro-tiazina e di-hidro-oxazina espirocíclicos, e composições e usos dos mesmos | |
| BRPI0714885B8 (pt) | compostos terapêuticos e seu uso | |
| TN2013000413A1 (en) | Glycoside derivatives and their uses for the treatment of diabetes | |
| ATE520651T1 (de) | Substituierte phenylmethylbicyclocarbonsäureamidverbindungen | |
| ATE442349T1 (de) | Diacylglycerol-acyltransferase-hemmer | |
| PH12013500644A1 (en) | Co-crystals and salts of ccr3-inhibitors | |
| WO2012168885A9 (en) | Bisacodyl and its analogues as drugs for use in the treatment of cancer | |
| GEP20135959B (en) | Aryl piperazine and their usage as alpha2c antagonists | |
| UA112556C2 (uk) | Інсектицидні похідні 2-метоксибензамідів | |
| MY198008A (en) | Crystal of benzofuran derivative free base and preparation method | |
| MX2013011926A (es) | Derivados de glicosido y usos de los mismos. | |
| BR112012013918A2 (pt) | inibidores de diacil glicerol acil transferase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |