AR061193A1 - PIRAZOL DERIVATIVES CONTAINING SULFUR AS SELECTIVE ANTAGONISTS OF THE CANNABINOID CB1 RECEIVER - Google Patents

PIRAZOL DERIVATIVES CONTAINING SULFUR AS SELECTIVE ANTAGONISTS OF THE CANNABINOID CB1 RECEIVER

Info

Publication number
AR061193A1
AR061193A1 ARP070102278A ARP070102278A AR061193A1 AR 061193 A1 AR061193 A1 AR 061193A1 AR P070102278 A ARP070102278 A AR P070102278A AR P070102278 A ARP070102278 A AR P070102278A AR 061193 A1 AR061193 A1 AR 061193A1
Authority
AR
Argentina
Prior art keywords
cannabinoid
receiver
containing sulfur
derivatives containing
selective antagonists
Prior art date
Application number
ARP070102278A
Other languages
Spanish (es)
Inventor
Josephus H M Lange
Cornelis G Kruse
Vliet Bernard J Van
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of AR061193A1 publication Critical patent/AR061193A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: Compuestos derivados de pirazol, caracterizados porque tienen la formula general (1) donde: R1 representa H, Cl o Br, R2 representa Cl o Br, X representa un átomo de azufre, un grupo funcional sulfoxido (S=O) o un grupo funcional sulfona (SO2), Y representa un grupo metilo o etilo, n representa el valor 1, 2 o 3, y tautomeros, estereoisomeros, prodrogas y N-oxidos de los mismos, y compuestos de formula 1 marcados isotopicamente, como sí también sales, hidratos y solvatos farmacologicamente aceptables de dichos compuestos de formula 1 y sus tautomeros, estereoisomeros, prodrogas, n-oxidos o análogos marcados isotopicamente.Claim 1: Compounds derived from pyrazole, characterized in that they have the general formula (1) wherein: R1 represents H, Cl or Br, R2 represents Cl or Br, X represents a sulfur atom, a sulfoxide functional group (S = O) or a sulfone (SO2) functional group, Y represents a methyl or ethyl group, n represents the value 1, 2 or 3, and tautomers, stereoisomers, prodrugs and N-oxides thereof, and compounds of formula 1 labeled isotopically, as if also pharmacologically acceptable salts, hydrates and solvates of said compounds of formula 1 and their tautomers, stereoisomers, prodrugs, n-oxides or isotopically labeled analogs.

ARP070102278A 2006-05-31 2007-05-28 PIRAZOL DERIVATIVES CONTAINING SULFUR AS SELECTIVE ANTAGONISTS OF THE CANNABINOID CB1 RECEIVER AR061193A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06114752 2006-05-31

Publications (1)

Publication Number Publication Date
AR061193A1 true AR061193A1 (en) 2008-08-13

Family

ID=37719834

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102278A AR061193A1 (en) 2006-05-31 2007-05-28 PIRAZOL DERIVATIVES CONTAINING SULFUR AS SELECTIVE ANTAGONISTS OF THE CANNABINOID CB1 RECEIVER

Country Status (6)

Country Link
CN (1) CN101454291A (en)
AR (1) AR061193A1 (en)
BR (1) BRPI0711902A2 (en)
MX (1) MX2008015272A (en)
SA (1) SA07280276B1 (en)
TW (1) TW200811143A (en)

Also Published As

Publication number Publication date
MX2008015272A (en) 2009-03-09
BRPI0711902A2 (en) 2011-12-13
TW200811143A (en) 2008-03-01
SA07280276B1 (en) 2010-06-15
CN101454291A (en) 2009-06-10

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