AR060856A1 - IMPROVED PROCEDURE TO PREPARE GABAPENTINE - Google Patents
IMPROVED PROCEDURE TO PREPARE GABAPENTINEInfo
- Publication number
- AR060856A1 AR060856A1 ARP070101943A ARP070101943A AR060856A1 AR 060856 A1 AR060856 A1 AR 060856A1 AR P070101943 A ARP070101943 A AR P070101943A AR P070101943 A ARP070101943 A AR P070101943A AR 060856 A1 AR060856 A1 AR 060856A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- gabapentine
- prepare
- aminomethyl
- salt
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un procedimiento en un unico recipiente para preparar ácido 1-(aminometil)-ciclohexanoacético o sales farmacéuticamente aceptables del mismo que comprende las etapas de hidrolizar éster etílico del ácido 1-cianociclohexanoacético con un hidroxido de potasio, sodio o litio para formar una sal del ácido 1-cianociclohexanoacético; hidrogenar in-situ la sal del ácido 1-cianociclohexanoacético en presencia de un catalizador para formar la sal del ácido 1-(aminometil)-ciclohexanoacético; y aislar el ácido 1-(aminometil)-ciclohexanoacético.A process in a single container for preparing 1- (aminomethyl) -cyclohexaneacetic acid or pharmaceutically acceptable salts thereof comprising the steps of hydrolyzing 1-cyanocyclohexane acetic acid ethyl ester with a potassium, sodium or lithium hydroxide to form a salt of the acid 1-cyanocyclohexaneacetic acid; hydrogenate in-situ the salt of 1-cyanocyclohexaneacetic acid in the presence of a catalyst to form the salt of 1- (aminomethyl) -cyclohexaneacetic acid; and isolate 1- (aminomethyl) -cyclohexaneacetic acid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE20060358A IE20060358A1 (en) | 2006-05-05 | 2006-05-05 | A process for preparing gabapentin |
PCT/IE2006/000049 WO2007129286A1 (en) | 2006-05-05 | 2006-05-05 | Process for preparing gabapentin |
Publications (1)
Publication Number | Publication Date |
---|---|
AR060856A1 true AR060856A1 (en) | 2008-07-16 |
Family
ID=38767186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101943A AR060856A1 (en) | 2006-05-05 | 2007-05-04 | IMPROVED PROCEDURE TO PREPARE GABAPENTINE |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP2007297386A (en) |
AR (1) | AR060856A1 (en) |
TW (1) | TW200812939A (en) |
-
2007
- 2007-04-27 JP JP2007118514A patent/JP2007297386A/en active Pending
- 2007-05-04 TW TW096115882A patent/TW200812939A/en unknown
- 2007-05-04 AR ARP070101943A patent/AR060856A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200812939A (en) | 2008-03-16 |
JP2007297386A (en) | 2007-11-15 |
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