AR059258A1 - METHODS TO INTERFER WITH THE GASTRIC ACID SECRETION INDUCED BY GLUCOCORTICOIDS - Google Patents

METHODS TO INTERFER WITH THE GASTRIC ACID SECRETION INDUCED BY GLUCOCORTICOIDS

Info

Publication number
AR059258A1
AR059258A1 ARP070100405A ARP070100405A AR059258A1 AR 059258 A1 AR059258 A1 AR 059258A1 AR P070100405 A ARP070100405 A AR P070100405A AR P070100405 A ARP070100405 A AR P070100405A AR 059258 A1 AR059258 A1 AR 059258A1
Authority
AR
Argentina
Prior art keywords
gastric acid
glucocorticoids
interfer
methods
glucocorticoid
Prior art date
Application number
ARP070100405A
Other languages
Spanish (es)
Inventor
Florian Lang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR059258A1 publication Critical patent/AR059258A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/062—Gastritis or peptic ulcer disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un método para alterar la secrecion de ácido gástrico inducida por glucocorticoides, que comprende poner en contacto células que expresan quinasa inducible por glucocorticoides del suero (SGK) con una sustancia que modula dicha quinasa inducible por glucocorticoides. Además, la presente se relaciona con el diagnostico y la identificacion de compuestos que pueden ser agonistas o antagonistas que son potencialmente utiles en la terapia de la secrecion patologica de ácido gástrico. Reivindicacion 1: Un método para alterar la secrecion de ácido gástrico que comprende poner en contacto células que expresan SGK1, SGK2 o SGK3 con una sustancia que modula las quinasas inducibles por glucocorticoides.A method for altering the secretion of gastric acid induced by glucocorticoids, which comprises contacting cells that express serum glucocorticoid-inducible kinase (SGK) with a substance that modulates said glucocorticoid-inducible kinase. In addition, this relates to the diagnosis and identification of compounds that may be agonists or antagonists that are potentially useful in the therapy of the pathological secretion of gastric acid. Claim 1: A method for altering gastric acid secretion comprising contacting cells expressing SGK1, SGK2 or SGK3 with a substance that modulates glucocorticoid inducible kinases.

ARP070100405A 2006-01-31 2007-01-31 METHODS TO INTERFER WITH THE GASTRIC ACID SECRETION INDUCED BY GLUCOCORTICOIDS AR059258A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06001934 2006-01-31

Publications (1)

Publication Number Publication Date
AR059258A1 true AR059258A1 (en) 2008-03-19

Family

ID=38006823

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070100405A AR059258A1 (en) 2006-01-31 2007-01-31 METHODS TO INTERFER WITH THE GASTRIC ACID SECRETION INDUCED BY GLUCOCORTICOIDS

Country Status (7)

Country Link
EP (1) EP1979747A1 (en)
JP (1) JP2009531020A (en)
AR (1) AR059258A1 (en)
AU (1) AU2007211655A1 (en)
CA (1) CA2641325A1 (en)
IL (1) IL193081A0 (en)
WO (1) WO2007087985A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210008193A (en) * 2019-07-10 2021-01-21 한양대학교 산학협력단 Use of Sgk1 inhibitor for treating inflammatory neurologic disorders
US20240024333A1 (en) * 2020-10-26 2024-01-25 Regents Of The University Of Minnesota Use of small molecule fak activators to promote mucosal healing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10346913A1 (en) * 2003-10-09 2005-05-04 Merck Patent Gmbh acylhydrazone
US20070191325A1 (en) * 2004-03-08 2007-08-16 Florian Lang Methods for altering insulin secretion
KR20070015148A (en) * 2004-03-11 2007-02-01 메르크 파텐트 게엠베하 Methods for modulating glutamate receptors for treating neuropsychiatric disorders comprising the use of modulators of serum and glucocorticoid inducible kinases
CN1964705A (en) * 2004-03-11 2007-05-16 默克专利有限公司 Methods for interfering with fibrosis
US20090136920A1 (en) * 2004-04-30 2009-05-28 Stefan Golz Diagnostics and therapeutics for diseases associated with serum/glucocorticoid regulated kinase 1 (sgk1)

Also Published As

Publication number Publication date
WO2007087985A1 (en) 2007-08-09
EP1979747A1 (en) 2008-10-15
JP2009531020A (en) 2009-09-03
IL193081A0 (en) 2009-02-11
CA2641325A1 (en) 2007-08-09
AU2007211655A1 (en) 2007-08-09

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