AR058393A1 - USE OF BENZO HETEROCICLIC DERIVATIVES - FUSIONATES OF SULFAMIDE FOR MODIFICATION OF THE DISEASE / EPILEPTOGENESIS - Google Patents
USE OF BENZO HETEROCICLIC DERIVATIVES - FUSIONATES OF SULFAMIDE FOR MODIFICATION OF THE DISEASE / EPILEPTOGENESISInfo
- Publication number
- AR058393A1 AR058393A1 ARP060105595A AR058393A1 AR 058393 A1 AR058393 A1 AR 058393A1 AR P060105595 A ARP060105595 A AR P060105595A AR 058393 A1 AR058393 A1 AR 058393A1
- Authority
- AR
- Argentina
- Prior art keywords
- epileptogenesis
- formula
- group
- benzo
- integer
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Método para tratar, prevenir, revertir, detener o inhibir la ocurrencia, el desarrollo y la maduracion de convulsiones o trastornos relacionados con las convulsiones. De un modo más específico, la presente se refiere a métodos para el uso de derivados heterocíclicos benzo-fusionados de sulfamida de formula (1) y formula (2) como se describe aquí, para tratar, prevenir, revertir, detener o inhibir en forma terapéutica o profiláctica la epileptogénesis y epilepsia. Reivindicacion 1: Un método para tratar la epileptogénesis, que comprende administrar a un paciente que necesita tratamiento con un fármaco anti-epileptogénico (un FAE), una cantidad terapéuticamente efectiva de un compuesto de formula (1) donde R1 y R2 se seleccionan, cada uno en forma independiente, del grupo que consiste en H y alquilo inferior; R4 se selecciona el grupo que consiste en H y alquilo inferior; a es un numero entero desde 1 hasta 2; el anillo R se selecciona del grupo que consiste en las formulas (3) a (9) donde b es un numero entero desde 0 hasta 4; y donde c es un numero entero desde 0 hasta 2; cada R5 se selecciona en forma independiente del grupo que consiste en halogeno, alquilo inferior y nitro; siempre que cuando el anillo R es como en formula (8) o (9), entonces a es 1; o una sal del mismo aceptable desde el punto de vista farmacéutico.Method to treat, prevent, reverse, stop or inhibit the occurrence, development and maturation of seizures or disorders related to seizures. More specifically, this refers to methods for the use of benzo-fused sulfamide heterocyclic derivatives of formula (1) and formula (2) as described herein, to treat, prevent, reverse, stop or inhibit therapeutic or prophylactic epileptogenesis and epilepsy. Claim 1: A method of treating epileptogenesis, comprising administering to a patient in need of treatment with an anti-epileptogenic drug (an FAE), a therapeutically effective amount of a compound of formula (1) wherein R1 and R2 are selected, each one independently, from the group consisting of H and lower alkyl; R4 is selected from the group consisting of H and lower alkyl; a is an integer from 1 to 2; the ring R is selected from the group consisting of formulas (3) a (9) where b is an integer from 0 to 4; and where c is an integer from 0 to 2; each R5 is independently selected from the group consisting of halogen, lower alkyl and nitro; provided that when the R ring is as in formula (8) or (9), then a is 1; or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75149605P | 2005-12-19 | 2005-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058393A1 true AR058393A1 (en) | 2008-01-30 |
Family
ID=38813248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105595 AR058393A1 (en) | 2005-12-19 | 2006-12-18 | USE OF BENZO HETEROCICLIC DERIVATIVES - FUSIONATES OF SULFAMIDE FOR MODIFICATION OF THE DISEASE / EPILEPTOGENESIS |
Country Status (6)
| Country | Link |
|---|---|
| CN (1) | CN101374513B (en) |
| AR (1) | AR058393A1 (en) |
| PE (1) | PE20071007A1 (en) |
| TW (1) | TWI398248B (en) |
| UA (1) | UA96590C2 (en) |
| UY (1) | UY30037A1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| AR049646A1 (en) * | 2004-06-16 | 2006-08-23 | Janssen Pharmaceutica Nv | USEFUL SULFAMATE AND SULFAMIDE DERIVATIVES FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS |
-
2006
- 2006-12-18 TW TW95147366A patent/TWI398248B/en not_active IP Right Cessation
- 2006-12-18 AR ARP060105595 patent/AR058393A1/en not_active Application Discontinuation
- 2006-12-19 CN CN2006800529733A patent/CN101374513B/en not_active Expired - Fee Related
- 2006-12-19 UA UAA200809400A patent/UA96590C2/en unknown
- 2006-12-19 PE PE2006001636A patent/PE20071007A1/en not_active Application Discontinuation
- 2006-12-19 UY UY30037A patent/UY30037A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI398248B (en) | 2013-06-11 |
| UA96590C2 (en) | 2011-11-25 |
| PE20071007A1 (en) | 2007-10-24 |
| CN101374513A (en) | 2009-02-25 |
| TW200800162A (en) | 2008-01-01 |
| UY30037A1 (en) | 2007-03-30 |
| CN101374513B (en) | 2013-11-27 |
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