AR057748A1 - DERIVATIVES OF 2,3 DIHYDROINDOL. PHARMACEUTICAL COMPOSITIONS - Google Patents

DERIVATIVES OF 2,3 DIHYDROINDOL. PHARMACEUTICAL COMPOSITIONS

Info

Publication number
AR057748A1
AR057748A1 ARP060103539A ARP060103539A AR057748A1 AR 057748 A1 AR057748 A1 AR 057748A1 AR P060103539 A ARP060103539 A AR P060103539A AR P060103539 A ARP060103539 A AR P060103539A AR 057748 A1 AR057748 A1 AR 057748A1
Authority
AR
Argentina
Prior art keywords
hydrogen
pharmaceutical compositions
independently selected
dihydroindol
derivatives
Prior art date
Application number
ARP060103539A
Other languages
Spanish (es)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR057748A1 publication Critical patent/AR057748A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Los compuestos usados en el tratamiento de un enfermedad en la cual están implicados un receptor D4 y / o un receptor 5-HT2A. Composiciones farmacéuticas. Reivindicacion 1: Un compuesto de la formula I en donde X-Y se selecciona de N-CH2, C=CH y CH- CH2; Z es CR10 o N; R1 es A, A' o A'' en las cuales *indica el átomo unido al N por medio de un enlace; R2 y R3 se seleccionan independientemente de hidrogeno y alquilo C1-6; R4 y R7 se seleccionan independientemente de hidrogeno, alquilo C1-6, alcoxilo C1-6 y halogeno; R8 y R9 se seleccionan independientemente de hidrogeno y halogeno; R10 es hidrogeno o halogeno; R11 y R12 se seleccionan independientemente de hidrogeno y alquilo C1-6; o enantiomeros o sales de los mismos.The compounds used in the treatment of a disease in which a D4 receptor and / or a 5-HT2A receptor are involved. Pharmaceutical compositions Claim 1: A compound of the formula I wherein X-Y is selected from N-CH2, C = CH and CH-CH2; Z is CR10 or N; R1 is A, A 'or A' 'in which * indicates the atom attached to N through a bond; R2 and R3 are independently selected from hydrogen and C1-6 alkyl; R4 and R7 are independently selected from hydrogen, C1-6 alkyl, C1-6 alkoxy and halogen; R8 and R9 are independently selected from hydrogen and halogen; R10 is hydrogen or halogen; R11 and R12 are independently selected from hydrogen and C1-6 alkyl; or enantiomers or salts thereof.

ARP060103539A 2005-08-17 2006-08-14 DERIVATIVES OF 2,3 DIHYDROINDOL. PHARMACEUTICAL COMPOSITIONS AR057748A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200501159 2005-08-17

Publications (1)

Publication Number Publication Date
AR057748A1 true AR057748A1 (en) 2007-12-12

Family

ID=37508275

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103539A AR057748A1 (en) 2005-08-17 2006-08-14 DERIVATIVES OF 2,3 DIHYDROINDOL. PHARMACEUTICAL COMPOSITIONS

Country Status (6)

Country Link
EP (1) EP1928860A1 (en)
JP (1) JP2009504691A (en)
CN (1) CN101243075A (en)
AR (1) AR057748A1 (en)
TW (1) TW200800960A (en)
WO (1) WO2007019867A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100868353B1 (en) 2007-03-08 2008-11-12 한국화학연구원 Piperazinyl-propyl-pyrazole derivatives as dopamine D4 receptor antagonists, and pharmaceutical compositions containing them
WO2015060348A1 (en) * 2013-10-23 2015-04-30 大日本住友製薬株式会社 Fused pyrazole derivative
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CN107915685A (en) * 2017-12-11 2018-04-17 重庆植恩药业有限公司 A kind of preparation method of hydrobromic acid Vortioxetine intermediate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives

Also Published As

Publication number Publication date
EP1928860A1 (en) 2008-06-11
CN101243075A (en) 2008-08-13
WO2007019867A1 (en) 2007-02-22
JP2009504691A (en) 2009-02-05
TW200800960A (en) 2008-01-01

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal