AR055282A1 - SALT L-TARTRATO OF N-1- ADAMANTIL -2- {3- [(2R) -2 - ({(2R) -2-HIDROXI-2- [4- HYDROXY-3- (HYDROXIMETHYL) PHENYL] ETIL} AMINO ) PROPIL] PHENYL} ACETAMIDE - Google Patents

SALT L-TARTRATO OF N-1- ADAMANTIL -2- {3- [(2R) -2 - ({(2R) -2-HIDROXI-2- [4- HYDROXY-3- (HYDROXIMETHYL) PHENYL] ETIL} AMINO ) PROPIL] PHENYL} ACETAMIDE

Info

Publication number
AR055282A1
AR055282A1 ARP050104741A ARP050104741A AR055282A1 AR 055282 A1 AR055282 A1 AR 055282A1 AR P050104741 A ARP050104741 A AR P050104741A AR P050104741 A ARP050104741 A AR P050104741A AR 055282 A1 AR055282 A1 AR 055282A1
Authority
AR
Argentina
Prior art keywords
phenyl
hydroxy
acetamide
amino
salt
Prior art date
Application number
ARP050104741A
Other languages
Spanish (es)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR055282A1 publication Critical patent/AR055282A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente se refiere a la sal L-tartrato de N-1-adamantil-2-{3-[(2R)-2-({(2R)-2-hidroxi-2-[4-hidroxi-3-(hidroximetil)fenil]etil}amino)propil]fenil}acetamida y a su uso como medicamento. Reivindicacion 2: Un compuesto segun la reivindicacion 1 que tiene un patron de difraccion por rayos X caracterizado por los siguientes picos principales del patron de difraccion por rayos X expresados en términos de ángulo 2-theta (longitud de onda = 1,54178 Angstroms) Angulo 2-theta(+/-0,1 grados),14,9, 16,7, 18,3, 19,1, 20,6, 20,9.It refers to the N-1-adamantyl-2- {3 - [(2R) -2 - ({(2R) -2-hydroxy-2- [4-hydroxy-3- (hydroxymethyl) L-tartrate salt ) phenyl] ethyl} amino) propyl] phenyl} acetamide and its use as a medicine. Claim 2: A compound according to claim 1 having an X-ray diffraction pattern characterized by the following main peaks of the X-ray diffraction pattern expressed in terms of 2-theta angle (wavelength = 1.54178 Angstroms) Angle 2-theta (+/- 0.1 degrees), 14.9, 16.7, 18.3, 19.1, 20.6, 20.9.

ARP050104741A 2004-11-12 2005-11-11 SALT L-TARTRATO OF N-1- ADAMANTIL -2- {3- [(2R) -2 - ({(2R) -2-HIDROXI-2- [4- HYDROXY-3- (HYDROXIMETHYL) PHENYL] ETIL} AMINO ) PROPIL] PHENYL} ACETAMIDE AR055282A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0425057A GB0425057D0 (en) 2004-11-12 2004-11-12 L-tartrate salt of N-1-adamantyl-2-{3-[(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]eth yl}amino)propyl]phenyl}acetamide

Publications (1)

Publication Number Publication Date
AR055282A1 true AR055282A1 (en) 2007-08-15

Family

ID=33523659

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104741A AR055282A1 (en) 2004-11-12 2005-11-11 SALT L-TARTRATO OF N-1- ADAMANTIL -2- {3- [(2R) -2 - ({(2R) -2-HIDROXI-2- [4- HYDROXY-3- (HYDROXIMETHYL) PHENYL] ETIL} AMINO ) PROPIL] PHENYL} ACETAMIDE

Country Status (8)

Country Link
AR (1) AR055282A1 (en)
GB (1) GB0425057D0 (en)
GT (1) GT200500328A (en)
NL (1) NL1030405C2 (en)
PE (1) PE20061131A1 (en)
TW (1) TW200630324A (en)
UY (1) UY29207A1 (en)
WO (1) WO2006051375A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2320961B1 (en) * 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) PHENOL AS BETA2 ADRENERGIC RECEIVER AGONISTS.
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071147A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2298511T3 (en) * 2002-04-25 2008-05-16 Glaxo Group Limited DERIVATIVES OF PHENETHANOLAMINE.
EP1460064A1 (en) * 2003-03-14 2004-09-22 Pfizer Limited Indole-2-carboxamide derivatives useful as beta-2 agonists
EP1577291A1 (en) * 2004-03-17 2005-09-21 Pfizer Limited Phenylethanolamine derivatives as beta-2 agonists

Also Published As

Publication number Publication date
GB0425057D0 (en) 2004-12-15
PE20061131A1 (en) 2006-10-20
TW200630324A (en) 2006-09-01
WO2006051375A1 (en) 2006-05-18
UY29207A1 (en) 2006-06-30
GT200500328A (en) 2006-06-02
NL1030405C2 (en) 2006-12-12
NL1030405A1 (en) 2006-05-15

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