AR054873A1 - PROCEDURE TO PRODUCE BEPROMOLINE - Google Patents

PROCEDURE TO PRODUCE BEPROMOLINE

Info

Publication number
AR054873A1
AR054873A1 ARP060103245A ARP060103245A AR054873A1 AR 054873 A1 AR054873 A1 AR 054873A1 AR P060103245 A ARP060103245 A AR P060103245A AR P060103245 A ARP060103245 A AR P060103245A AR 054873 A1 AR054873 A1 AR 054873A1
Authority
AR
Argentina
Prior art keywords
bepromoline
procedure
produce
compound
formula
Prior art date
Application number
ARP060103245A
Other languages
Spanish (es)
Inventor
Beat Weber
Stefan Rosenberg
Original Assignee
Galderma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa filed Critical Galderma Sa
Publication of AR054873A1 publication Critical patent/AR054873A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicacion 1: Procedimiento para la fabricacion de un compuesto de formula (1) y dicho procedimiento consiste en: (i) poner en contacto un compuesto de formula (2) con un compuesto de formula (3) en presencia de un catalizador de paladio, metanol y gas de hidrogeno, caracterizado porque (ii) una vez finalizado el consumo de gas de hidrogeno, se agrega ácido acético.Claim 1: Process for the manufacture of a compound of formula (1) and said process consists of: (i) contacting a compound of formula (2) with a compound of formula (3) in the presence of a palladium catalyst, methanol and hydrogen gas, characterized in that (ii) once the consumption of hydrogen gas is finished, acetic acid is added.

ARP060103245A 2005-07-28 2006-07-27 PROCEDURE TO PRODUCE BEPROMOLINE AR054873A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05291611A EP1749826A1 (en) 2005-07-28 2005-07-28 Process of producing bepromoline

Publications (1)

Publication Number Publication Date
AR054873A1 true AR054873A1 (en) 2007-07-25

Family

ID=35064906

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103245A AR054873A1 (en) 2005-07-28 2006-07-27 PROCEDURE TO PRODUCE BEPROMOLINE

Country Status (12)

Country Link
US (2) US7795425B2 (en)
EP (2) EP1749826A1 (en)
AR (1) AR054873A1 (en)
BR (1) BRPI0613307B8 (en)
CA (1) CA2616160C (en)
CY (1) CY1113779T1 (en)
DK (1) DK1912961T3 (en)
ES (1) ES2399245T3 (en)
PL (1) PL1912961T3 (en)
PT (1) PT1912961E (en)
SI (1) SI1912961T1 (en)
WO (1) WO2007012984A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1749826A1 (en) * 2005-07-28 2007-02-07 Galderma S.A. Process of producing bepromoline
EP1935889A1 (en) * 2006-12-21 2008-06-25 Galderma S.A. Process of producing amorolfine
ITFI20090032A1 (en) * 2009-02-20 2010-08-21 Synteco S P A Prodotti Di Sintesi Per L Ind INDUSTRIAL PRODUCTION PROCESS OF CHLORIDATED AMOROLFIN
WO2011066735A1 (en) * 2009-12-01 2011-06-09 Zhejiang Hisoar Pharmaceutical Co., Ltd An Amorolfine HCl Crystal and the Preparation thereof
CN102887872B (en) * 2011-12-30 2015-06-24 浙江海翔药业股份有限公司 Method for preparing amorolfine hydrochloride
CN109232458A (en) * 2018-06-15 2019-01-18 南通常佑药业科技有限公司 A kind of preparation method of chirality morpholinium compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046280A (en) * 1955-11-24 1962-07-24 Philips Corp Primary, secondary and tertiary amines having a spasmolytic effect and method of producing these compounds
AT354187B (en) * 1976-11-22 1979-12-27 Hoffmann La Roche FUNGICIDE AGENT
DE2656747C2 (en) * 1976-12-15 1984-07-05 Basf Ag, 6700 Ludwigshafen Morpholine derivatives
US4283534A (en) * 1979-04-11 1981-08-11 Basf Aktiengesellschaft Reductive alkylation of nitrogen heterocycles
IT1220970B (en) 1979-08-17 1990-06-21 Hoffmann La Roche HETEROCYCLIC COMPOUNDS WITH PARTICULAR FUNGICIDE ACTION FOR THE FIGHT AGAINST CANDIDA ALBICANS
EP1749826A1 (en) * 2005-07-28 2007-02-07 Galderma S.A. Process of producing bepromoline
EP1935889A1 (en) * 2006-12-21 2008-06-25 Galderma S.A. Process of producing amorolfine

Also Published As

Publication number Publication date
US8242268B2 (en) 2012-08-14
EP1749826A1 (en) 2007-02-07
US7795425B2 (en) 2010-09-14
BRPI0613307A2 (en) 2010-12-28
CA2616160C (en) 2014-02-11
PL1912961T3 (en) 2013-04-30
DK1912961T3 (en) 2013-02-11
EP1912961A2 (en) 2008-04-23
EP1912961B1 (en) 2012-12-05
CY1113779T1 (en) 2016-07-27
BRPI0613307B1 (en) 2021-04-06
PT1912961E (en) 2013-02-04
CA2616160A1 (en) 2007-02-01
US20080269483A1 (en) 2008-10-30
ES2399245T3 (en) 2013-03-26
BRPI0613307B8 (en) 2021-05-25
US20100311967A1 (en) 2010-12-09
WO2007012984A3 (en) 2007-06-14
WO2007012984A2 (en) 2007-02-01
SI1912961T1 (en) 2013-04-30

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Legal Events

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